In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins

FEMS Yeast Research

Volumn 6, Issue 8, 2006, Pages 1157-1166

  Otzen, Marleen ^a   Krikken, Arjen M ^a   Ozimek, Paulina Z ^a   Kurbatova, Elena ^a   Nagotu, Shirisha ^a   Veenhuis, Marten ^a   Van Der Klei, Ida J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Endoplasmic reticulum; Hansenula polymorpha; p24 proteins; Peroxisome biogenesis; Pex19p; Yeast

Indexed keywords

GAG PROTEIN; PEROXIN; PROTEIN PEX19P; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS MEMBRANE; CELL ORGANELLE; COATED VESICLE; CONTROLLED STUDY; EMP24 GENE; ENDOPLASMIC RETICULUM; ERP3 GENE; FUNGAL CELL; FUNGAL GENE; GENE DELETION; GOLGI COMPLEX; HANSENULA POLYMORPHA; NONHUMAN; NUCLEOTIDE SEQUENCE; PEROXISOME; PEX19 GENE; PROTEIN FARNESYLATION; PROTEIN PROCESSING; WILD TYPE;

ENDOPLASMIC RETICULUM; FUNGAL PROTEINS; MEMBRANE PROTEINS; PEROXISOMES; PICHIA; VESICULAR TRANSPORT PROTEINS;

PICHIA ANGUSTA;

EID: 33750436981     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2006.00102.x     Document Type: Article

References (30)

1. Baerends RJS, Faber KN, Kram AM, Kiel JAKW, van der Klei IJ & Veenhuis M (2000) A stretch of positively charged amino acids at the N terminus of Hansenula polymorpha pex3p is involved in incorporation of the protein into the peroxisomal membrane. J Biol Chem 275: 9986-9995.
2. Carney GE & Bowen NJ (2004) p24 Proteins, intracellular trafficking, and behaviour: Drosophila melanogaster provides insights and opportunities. Biol Cell 96: 271-278.
3. Faber KN, Haan GJ, Baerends RJ, Kram AM & Veenhuis M (2002) Normal peroxisome development from vesicles induced by truncated Hansenula polymorpha Pex3p. J Biol Chem 277: 11026-11033.
4. Fagarasanu M, Fagarasanu M, Tam YYC, Aitchison JD & Rachubinski RA (2005) Inp1p is a peroxisomal membrane protein required for peroxisome inheritance in Saccharomyces cerevisiae. J Cell Biol 169: 765-775.
5. Geuze HJ, Murk JL, Stroobants AK, Griffith JM, Kleijmeer MJ, Koster AJ, Verkleij AJ, Distel B & Tabak HF (2003) Involvement of the endoplasmic reticulum in peroxisome formation. Mol Biol Cell 14: 2900-2907.
6. Götte K, Girzalsky W, Linkert M, Baumgart E, Kammerer S, Kunau WH & Erdmann R (1998) Pex19p, a farnesylated protein essential for peroxisome biogenesis. Mol Cell Biol 18: 616-628.
7. Haan GJ, Baerends RJ, Krikken AM, Otzen M, Veenhuis M & van der Klei IJ (2006) Re-assembly of peroxisomes in Hansenula polymorpha pex3 cells upon re-introduction of Pex3p involves the nuclear envelope. FEMS Yeast Res 6: 186-194.
8. Hettema EH, Girzalsky W, van den Berg M, Erdmann R & Distel B (2000) Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins. EMBO J 19: 223-233.
9. Hoepfner D, Schildknegt D, Braakman I, Philippsen P & Tabak HF (2005) Contribution of the endoplasmic reticulum to peroxisome formation. Cell 122: 85-95.
10. Hoepfner D, van den Berg M, Philippsen P, Tabak HF & Hettema EH (2001) A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae. J Cell Biol 155: 979-990.
11. Kiel JA, Hilbrands RE, van der Klei IJ, Rasmussen SW, Salomons FA, van der Heide M, Faber KN, Cregg JM & Veenhuis M (1999) Hansenula polymorpha Pex1p and Pex6p are peroxisome-associated AAA proteins that functionally and physically interact. Yeast 15: 1059-1078.
12. Koch A, Schneider G, Luers GH & Schrader M (2004) Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1. J Cell Sci 117: 3995-4006.
13. Koch A, Thiemann M, Grabenbauer M, Yoon Y, Mc Niven MA & Schrader M (2003) Dynamin-like protein 1 is involved in peroxisomal fission. J Biol Chem 278: 8597-8605.
14. Komori M, Rasmussen SW, Kiel JAKW, Baerends RJS, Cregg JM, van der Klei IJ & Veenhuis M (1997) The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesis. EMBO J 16: 44-53.
15. Kragt A, Voorn-Brouwer T, van den Berg M & Distel B (2005) Endoplasmic reticulum-directed Pex3p routes to peroxisomes and restores peroxisome formation in a Saccharomyces cerevisiae pex3Delta strain. J Biol Chem 280: 34350-34357.
16. Lambkin GR & Rachubinski RA (2001) Yarrowia lipolytica cells mutant for the peroxisomal peroxin Pex19p contain structures resembling wild-type peroxisomes. Mol Biol Cell 12: 3353-3364.
17. Lazarow PB & Fujiki Y (1985) Biogenesis of peroxisomes. Annu Rev Cell Biol 1: 489-530.
18. Li X & Gould SJ (2003) The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11. J Biol Chem 278: 17012-17020.
19. Marelli M, Smith J, Jung S, et al. (2004) Quantitative mass spectroscopy reveals a role for the GTPase Rho1p in actin organization on the peroxisomal membrane. J Cell Biol 167: 1099-1112.
20. Matsuzono Y, Kinoshita N, Tamura S, Shimozawa N, Hamasaki M, Ghaedi K, Wanders RJ, Suzuki Y, Kondo N & Fujiki Y (1999) Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly. Proc Natl Acad Sci USA 96: 2116-2121.
21. Otzen M, Perband U, Wang D, Baerends RJ, Kunau WH, Veenhuis M & van der Klei IJ (2004) Hansenula polymorpha Pex19p is essential for the formation of functional peroxisomal membranes. J Biol Chem 279: 19181-19190.
22. Ramezani-Rad M, Hollenberg CP, Lauber J, et al. (2003) The Hansenula polymorpha (strain CBS4732) genome sequencing and analysis. FEMS Yeast Res 4: 207-215.
23. Schimmoller F, Singer-Kruger B, Schroder S, Kruger U, Barlowe C & Riezman H (1995) The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi. EMBO J 14: 1329-1339.
24. Schliebs W & Kunau WH (2004) Peroxisome membrane biogenesis: the stage is set. Curr Biol 14: R397-R399.
25. Snyder WB, Faber KN, Wenzel TJ, Koller A, Luers GH, Rangell L, Keller GA & Subramani S (1999) Pex19p interacts with pex3p and pex10p and is essential for peroxisome biogenesis in Pichia pastoris. Mol Biol Cell 10: 1745-1761.
26. Springer S, Chen E, Duden R, Marzioch M, Rowley A, Hamamoto S, Merchant S & Schekman R (2000) The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 97: 4034-4039.
27. Tam YY, Fagarasanu A, Fagarasanu M & Rachubinski RA (2005) Pex3p initiates the formation of a preperoxisomal compartment from a subdomain of the endoplasmic reticulum in Saccharomyces cerevisiae. J Biol Chem 280: 34933-34939.
28. Titorenko VI & Rachubinski RA (2001) The life cycle of the peroxisome. Nat Rev Mol Cell Biol 2: 357-368.
29. van der Klei IJ, Harder W & Veenhuis M (1991) Methanol metabolism in a peroxisome-deficient mutant of Hansenula polymorpha: a physiological study. Arch Microbiol 156: 15-23.
30. Yan M, Rayapuram N & Subramani S (2005) The control of peroxisome number and size during division and proliferation. Curr Opin Cell Biol 17: 376-383.