Systemic autoimmune disorders in celiac disease

Current Opinion in Gastroenterology

Volumn 22, Issue 6, 2006, Pages 674-679

  Fasano, Alessio ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity; Innate immunity; Intestinal permeability; Tight junctions; Toll receptors

Indexed keywords

GAMMA INTERFERON; GLUTEN; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL DISTENSION; ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; CELIAC DISEASE; COMORBIDITY; CROHN DISEASE; DIARRHEA; DISEASE ASSOCIATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GLUTEN FREE DIET; HUMAN; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE BIOPSY; LITERATURE; LOGISTIC REGRESSION ANALYSIS; ONSET AGE; PREVALENCE; REVIEW; SYMPTOM; T LYMPHOCYTE; WEIGHT REDUCTION;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CELIAC DISEASE; DISEASE PROGRESSION; HUMANS; IMMUNITY, NATURAL;

EID: 33750375667     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mog.0000245543.72537.9e     Document Type: Review

References (37)

1. Sollid LM, Jabri B. Is celiac disease an autoimmune disorder? Curr Opin Immunol 2005; 17:595-600. This is a good review focused on the immunological aspects of celiac disease. The review presents strong arguments on why celiac disease should now be considered an autoimmune disorder.
2. Fasano A. Celiac disease: how to handle a clinical chameleon. N Engl J Med 2003; 348:2568-2570.
3. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology 2001; 120:636-651.
4. Ventura A, Magazzu G, Greco L. Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease. Gastroenterology 1999; 117:297-303.
5. Not T, Tommasini A, Tonini G, et al. Undiagnosed coeliac disease and risk of autoimmune disorders in subjects with Type I diabetes mellitus. Diabetologia 2001; 44:151-155.
6. Cataldo F, Marino V. Increased prevalence of autoimmune diseases in first-degree relatives of patients with celiac disease. J Pediatr Gastroenterol Nutr 2003; 36:470-473.
7. Sategna Guidetti C, Solerio E, Scaglione N, et al. Duration of gluten exposure in adult coeliac disease does not correlate with the risk for autoimmune disorders. Gut 2001; 49:502-505.
8. Funda DP, Kaas A, Bock T, et al. Gluten-free diet prevents diabetes in NOD mice. Diabetes Metab Res Rev 1999; 15:323-327.
9. Maurano F, Mazzarella G, Luongo D, et al. Small intestinal enteropathy in nonobese diabetic mice fed a diet containing wheat. Diabetologia 2005; 48:931-937. This paper shows that the effect of gluten on intestinal mucosal inflammation is not limited to celiac disease genetic background, but can also occur on a T1D genetic background.
10. Ziegler A, Schmid S, Huber D, et al. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 2003; 290:1721-1728.
11. Ventura A, Neri E, Ughi C, et al. Gluten-dependent diabetes-related and thyroid-related autoantibodies in patients with celiac disease. J Pediatr 2000; 137:263-265.
12. Auricchio R, Paparo F, Maglio M, et al. In vitro deranged intestinal immune response to gliadin in type 1 diabetes. Diabetes 2004; 53:1680-1683.
13. Sblattero D, Ventura A, Tommasini A. Cryptic gluten intolerance in type 1 diabetes: identifying suitable candidates for a gluten free diet. Gut 2006; 55:133-134. This paper shows for the first time a direct link between the exposure to gluten and an immune response at the intestinal level in subjects affected by T1D.
14. Kumar V, Rajadhyaksha M, Wortman J. Celiac disease-associated autoimmune endocrinopathies. Clin Diagn Lab Immunol 2001; 8:678-685.
15. Collin P, Reunala T, Pukkala E, et al. Coeliac disease-associated disorders and survival. Gut 1994; 35:1215-1218.
16. Tanure MG, Silva IN, Bahia M, Penna FJ. Prevalence of celiac disease in Brazilian children with type 1 diabetes mellitus. J Pediatr Gastroenterol Nutr 2006; 42:155-159.
17. Mahmud FH, Murray JA, Kudva YC, et al. Celiac disease in type 1 diabetes mellitus in a North American community: prevalence, serologic screening, and clinical features. Mayo Clin Proc 2005; 80:1429-1434.
18. Saadah OI, Zacharin M, O'Callaghan A, et al. Effect of gluten-free diet and adherence on growth and diabetic control in diabetics with celiac disease. Arch Dis Child 2004; 89:871-876.
19. Peretti N, Bienvenu F, Bouvet C, et al. The temporal relationship between the onset of type 1 diabetes and celiac disease: a study based on immunoglobulin a antitransglutaminase screening. Pediatrics 2004; 113:E418-E422.
20. Sumnik Z, Cinek O, Bratanic N, et al. Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02- DQA1*05 and TNF -308A. Diabetes Care 2006; 29:858-863. A well-designed study aimed at establishing whether genetic polymorphirms are responsible of celiac disease-T1D comorbidity.
21. Kaspers S, Kordonouri O, Schober E, et al. Anthropometry, metabolic control, and thyroid autoimmunity in type 1 diabetes with celiac disease: a multicenter survey. J Pediatr 2004; 145:790-795.
22. Aycan Z, Berberoglu M, Adiyaman P, et al. Latent autoimmune diabetes mellitus in children (LADC) with autoimmune thyroiditis and celiac disease. J Pediatr Endocrinol Metab 2004; 17:1565-1569.
23. Berti I, Trevisiol C, Tommasini A, et al. Usefulness of screening program for celiac disease in autoimmune thyroiditis. Dig Dis Sci 2000; 45:403-406.
24. Verslype C. Evaluation of abnormal liver-enzyme results in asymptomatic patients. Acta Clin Belg 2004; 59:285-289.
25. Mainardi E, Montanelli A, Dotti M, et al. Thyroid-related autoantibodies and celiac disease: a role for a gluten-free diet? J Clin Gastroenterol 2002; 35:245-248.
26. da Silva Kotze LM, Nisihara RM, Da Rosa Utiyama SR, et al. Thyroid disorders in Brazilian patients with celiac disease. J Clin Gastroenterol 2006; 40:33-36.
27. Sumnik Z, Cinek O, Bratanic N, et al. Thyroid autoimmunity in children with coexisting type 1 diabetes mellitus and celiac disease: a multicenter study. J Pediatr Endocrinol Metab 2006; 19:517-522.
28. Fasano A, Shea-Donohue T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol 2005; 2:416-422. This is a good review on the role of intestinal permeability and the gut-associated lymphoid tissue in the pathogenesis of autoimmune diseases, including celiac disease and T1D.
29. Bjarnason I, Takeuchi K, Bjarnason A, et al. The G.U.T. of gut. Scand J Gastroenterol 2004; 39:807-815.
30. Wendling D. Role of the intestine in the physiopathology of inflammatory rheumatism. Rev Rhum Mal Osteoartic 1992; 59:389-392.
31. Watts T, et al. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci USA 2005; 102:2916-2921. This paper demonstrates the key role of the impairment of intestinal barrier function secondary to the zonulin effect on tight junctions on the pathogenesis of T1D.
32. Madara JL, Trier JS. Structural abnormalities of jejunal epithelial cell membranes in celiac sprue. Lab Invest 1980; 43:254-261.
33. Schulzke JD, Bentzel CJ, Schulzke I, et al. Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr Res 1980; 43:435-441.
34. Fasano A, et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 2000; 355:1518-1519.
35. Clemente MG, et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 2003; 52:218-223.
36. Nikulina M, Habich C, Flohe SB, et al. Wheat gluten causes dendritic cell maturation and chemokine secretion. J Immunol 2004; 173:1925-1933.
37. Thomas KE, Sapone A, Fasano A, Vogel SN. Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in celiac disease. J Immunol 2006; 176:2512-2521. This paper reports the effect of the celiac disease trigger gliadin on macrophage inflammatory gene expression and intestinal barrier function in a normal murine animal model, and the dependence of this effect on the MyD88 signaling.