Toxicity of ornidazole and its analogues to rat spermatozoa as reflected in motility parameters

International Journal of Andrology

Volumn 20, Issue 6, 1998, Pages 347-355

  Bone, W ^a   Yeung, C H ^a   Skupin, R ^b   Haufe, G ^b   Cooper, T G ^a,c  

^a Institute of Reproductive Medicine   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c INST OF REPRO MED OF THE UNIV   (Germany)

Author keywords

Ornidazole; Rat; Sperm motility; Spermatozoa; Toxicity

Indexed keywords

IMIDAZOLE DERIVATIVE; ORNIDAZOLE;

ANIMAL EXPERIMENT; ARTICLE; COMPUTER ANALYSIS; EPIDIDYMIS; EPITHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPERMATOZOON; SPERMATOZOON MOTILITY;

EID: 0031462530     PISSN: 01056263     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2605.1998.00077.x     Document Type: Article

References (22)

1. Coper, T. G., Yeung, C. H., Skupin, R. & Haufe, G. (1997) Antifertility potential of ornidazole analogues in rats. Journal of Andrology, 18, 431-438.
2. Cosar, C., Crisan, C., Horclois, R., Jacob, R. M., Robert, J., Tchelitcheff, S. & Vaupré, R. (1966) Nitro-imidazoles - Préparation et activité chimiothérapeutique. Arzneimittel-Forschung (Drug Research), 16, 23-29.
3. Edwards, D. I., Dye, M. & Carne, H. (1973) The selective toxicity of antimicrobial nitroheterocyclic drugs. Journal of General Microbiology, 76, 135-145.
4. Jackson, H. & Robinson, D. (1976) The antifertility effects of alpha-chlorohydrins and their stereo-isomers in male rats. Chemical-Biological Interactions, 13, 193-197.
5. Jackson, H., Rooney, F. R., Fitzpatrick, R. W. & Gibson (1977) Characterization and antifertility activity in rats of S (+) alpha-chlorohydrin. Chemical-Biological Interactions, 17, 117-120.
6. 36Cl-ornidazole after oral application to the male rat in relation to its antifertility activity. Xenobiotica, 27, 711-721.
7. Jones, A. R. & Stevenson, D. (1983) Formation of the active antifertility metabolite of (S)-alpha-chlorohydrin in boar sperm. Experientia, 39, 784-785.
8. Latscha, H. P. & Klein, H. A. (1996) Chemie Für Pharmazeuten Und Biowissenschaftler, Springer Verlag, Berlin.
9. McClain, R. M. & Downing, J. C. (1988a) The effect of ornidazole on fertility and epididymal sperm function in rats. Toxicology and Applied Pharmacology, 92, 488-496.
10. McClain, R. M. & Downing, J. C. (1988b) Reproduction studies in rats treated with ornidazole. Toxicology and Applied Pharmacology, 92, 480-487.
11. Oberländer, G., Yeung, C. H. & Cooper, T. G. (1994) Induction of reversible infertility in male rats by oral ornidazole and its effects on sperm motility and epididymal secretions. Journal of Reproduction and Fertility, 100, 551-559.
12. Oberländer, G., Yeung, C. H. & Cooper, T. G. (1996) Influence of oral administration of ornidazole on capacitation and the activity of some glycolytic enzymes of rat spermatozoa. Journal of Reproduction and Fertility, 106, 231-239.
13. Porter, K. E. & Jones, A. E. (1982) The effect of the isomers of alpha-chlorohydrin and racemic beta-chlorolactate on the rat kidney. Chemical-Biological Interactions, 41, 95-104.
14. Rao, D. N. R., Jordan, S. & Mason, R. P. (1988) Generation of nitro radical anions of some 5-nitrofurans, 2- and 5-nitroimidazoles by rat hepatocytes. Biochemical Pharmacology, 37, 2907-2913.
15. Schwartz, D. E., Jordan, J. C., Vetter, W. & Oesterholt, G. (1979) Metabolic studies of ornidazole in the rat, in the dog and in man. Xenobiotica, 9, 571-581.
16. Skupin, R., Cooper, T. G., Fröhlich, R., Prigge, I. & Haufe, G. (1997) Lipase-catalysed resolution of both enantiomers of ornidazole & some analogues. Tetrahedron: Asymmetry, 8, 2453-2464.
17. Stevenson, D. & Jones, A. R. (1984) The action of (R)- and (S)-alpha-chlorohydrin and their metabolites on the metabolism of boar sperm. International Journal of Andrology, 7, 79-86.
18. Stevenson, D. & Jones, A. R. (1982) Inhibition of fructolysis in boar spermatozoa by the male antifertility agent (S)-alpha-chlorohydrin. Australian Journal of Biological Sciences, 35, 595-605.
19. Stevenson, D. & Jones, A. R. (1985) Production of (S)-3-chlorolactaldehyde from (S)-alpha-chlorohydrin by boar spermatozoa and the inhibition of glyceraldehyde 3-phosphate dehydrogenase in vitro. Journal of Reproduction and Fertility, 74, 157-165.
20. Taburet, A. M., Attali, P., Bourget, P., Etienne, J. P. & Singlas, E. (1989) Pharmacokinetics of ornidazole in patients with acute viral hepatitis, alcoholic cirrhosis, and extrahepatic cholestasis. Clinical Pharmacology and Therapy, 45, 373-379.
21. Toth, G. P., Wang, S.-R., McCarthy, H., Tocco, D. R. & Smith, M. K. (1992) Effects of three male reproductive reproductive toxicants on rat cauda epididymal sperm motion. Reproductive Toxicology, 6, 507-515.
22. Yeung, C.H., Oberländer, G. & Cooper, T. G. (1995) Effects of the male antifertility agent ornidazole on sperm function in vitro and in the female genital tract. Journal of Reproduction and Fertility, 103, 257-264.