Antifertility potential of ornidazole analogues in rats

Journal of Andrology

Volumn 18, Issue 4, 1997, Pages 431-438

  Cooper, Trevor G ^a,c   Yeung, Ching Hei ^a   Skupin, Rolf ^b   Haufe, Günter ^b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c INST OF REPRO MED OF THE UNIV   (Germany)

Author keywords

CASA; Contraception; Epididymis; Fertility; Nitroimidazoles; Sperm motility

Indexed keywords

ALPHA CHLOROHYDRIN; NITROIMIDAZOLE DERIVATIVE; ORNIDAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTRACEPTION; CONTROLLED STUDY; CORPUS LUTEUM; DRUG STRUCTURE; EPIDIDYMIS; FEMALE; FERTILITY; MALE; MALE FERTILITY; MATING; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SPERMATOZOON MOTILITY;

ANIMALS; BODY WEIGHT; CONTRACEPTIVE AGENTS, MALE; FERTILITY; HEMATOCRIT; MALE; ORGAN SIZE; ORNIDAZOLE; RATS; RATS, SPRAGUE-DAWLEY; SPERM MOTILITY;

EID: 0030784930     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Author collective. Organikum - Organisch-chemisches Grundpraktikum. Leipzig, Germany: Johann Ambrosius Barth; 1993.
2. Banik UK, Tanikella T, Rakhit S. Oral antifertility effects of halo propanediol derivatives on male rats. J Reprod Fertil 1972;30:117-124.
3. Bedford JM. Sperm dynamics in the epididymis. In: Asch RA, Balmaceda JP, Johnston I, eds. Gamete Physiology. Norwell, Massachusetts: Serono Symposia; 1990:53-67.
4. Brown-Woodman PDC, White IG, Ridley DD. The antifertility activity and toxicity of α-chlorohydrin derivatives in male rats. Contraception 1979;19:517-529.
5. Cavanagh JB. Selective vulnerability in acute energy deprivation syndromes. Neuropathol Appl Neurophysiol 1993;19:461-470.
6. Cavanagh JB, Nolan CC. The neurotoxicity of α-chlorohydrin in rats and mice: II. Lesion topography and factors in selective vulnerability in acute energy deprivation syndromes. Neuropathol Appl Neurobiol 1993;19:471-479.
7. Cavanagh JB, Nolan CC, Seville MP. The neurotoxicity of α-chlorohydrin in rats and mice: I. Evolution of the cellular changes. Neuropathol Appl Neurobiol 1993;19:240-252.
8. Cooper ERA, Jones AR, Jackson H. Effects of α-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat. J Reprod Fertil 1974;38:379-386.
9. Ericsson RJ, Baker VF. Male antifertility agents: biological properties of U-5897 and U-15,646. J Reprod Fertil 1970;21:267-273.
10. Ford WCL. The contraceptive effect of 6-chloro-6-deoxysugars in the male. In: Cunningham GR, Schill W-B, Hafez ESE, eds. Regulation of Male Fertility. The Hague: Martinus Nijhoff; 1980:123-126.
11. Hoffer M, Grunberg E. Synthesis and antiprotozoal activity of 1-(3-chloro-2-hydroxypropyl)-substituted nitroimidazoles. J Med Chem 1974;17:1019-1020.
12. Hoffmann F-La Roche and Co., Patent "Imidazole derivatives," Netherlands patent application no. 6.606.853 Nov. 21, 1966. Chem Abs 1968;68:21933r.
13. Jackson H, Campbell ISC, Jones AR. Is glycidol an active intermediate in the antifertility action of α-chlorohydrin in male rats? Nature (Lond) 1970;224:86-87.
14. Jones AR, Mashford M, Murcott PM. The metabolism of 3-amino-1-chloropropan-2-ol in relation to its antifertility activity in male rats. Xenobiotica 1979;9:253-261.
15. Jones AR, Murcott C, Milton DH, Flynn J. The metabolism of the male antifertility agent 1-amino-3-chloropropan-2-ol in the rat. Experientia 1977;33:934-935.
16. Jones AR, O'Brien RW. Metabolism of three active analogues of the male antifertility agent α-chlorohydrin in the rat. Xenobiotica 1980;10:365-370.
17. Klinefelter GR, Laskey JW, Perreault SD, Ferrell J, Jeffay S, Suarez J, Roberts N. The ethane dimethanesulphonate-induced decrease in the fertilizing ability of cauda epididymal sperm is independent of the testis. J Androl 1994;15:318-327.
18. Linder RE, Strader LF, Slott VL, Suarez JD. Endpoints of spermatoxicity in the rat after short duration exposures to fourteen reproductive toxins. Reprod Toxicol 1992;6:491-505.
19. Lobl TJ. α-Chlorohydrin: a review of a model posttesticular antifertility agent. In: Cunningham GR, Schill W-B, Hafez ESE, eds. Regulation of Male Fertility. The Hague: Martinus Nijhoff; 1980:109-122.
20. McClain RM, Downing JC. The effect of ornidazole on fertility and epididymal sperm function in rats. Toxicol Appl Pharmacol 1988;92: 488-496.
21. McClain RM, Downing JC, Edgcomb JE. Effect of metronidazole on fertility and testicular function in male rats. Fundament Appl Toxicol 1989;12:386-396.
22. Mitruka BM, Rawnsley HM. Clinical Biochemical and Hematological Reference Values in Normal Experimental Animals. New York: Masson Publishing Co; 1977.
23. Oberländer G, Yeung CH, Cooper TG. Induction of reversible infertility in male rats by oral ornidazole and its effects on sperm motility and epididymal secretions. J Reprod Fertil 1994;100:551-559.
24. Oberländer G, Yeung CH, Cooper TG. Influence of oral administration of ornidazole on capacitation and the activity of some glycolytic enzymes of rat spermatozoa. J Reprod Fertil 1996;106:231-239.
25. Richle vR, Scholer HJ, Angehrn P, Fernex M, Hummler H, Jennet F, Schrärer K, Schüpbach M, Schwartz DE. Grundlagen der Chemotherapie von Trichomoniasis und Amoebiasis mit Ornidazol. Arzneim Forsch 1978;28:612-625.
26. Schwartz DE, Hofheinz W. Metabolism of nitroimidazoles. In: Breccia A, Cavalleri B, Adams GE, eds. Nitroimidazoles: Chemistry, Pharmacology, and Clinical Applications. New York: Plenum Press; 1982: 91-104.
27. Schwartz DE, Jordan J-C, Vetter W, Oesterhelt G. Metabolic studies of ornidazole in the rat, in the dog and in man. Xenobiotica 1979;9:571-581.
28. Slott VL, Suarez JD, Poss PM, Linder RE, Strader LF, Perreault SD. Optimization of the Hamilton-Thorn computerized sperm motility analysis system for use with rat spermatozoa in toxicological studies. Fundament Appl Toxicol 1993;21:298-307.
29. Titus EO, Craig LC. Metabolic studies of 4-aminoquinolones. J Org Chem 1948;13:39-50.
30. Toth GP, Wang SR, McCarthy H, Tocco DR, Smith MK. Effects of three male reproductive toxicants on rat cauda epididymal sperm motion. Reprod Toxicol 1992;6:507-515.
31. Vickery BH. Non-steroidal interference with male fertility. Adv Contracept 1986;2:1-30.
32. Vickery BH, Erickson GI, Bennett JP. Mechanisms of antifertility action of low doses of α-chlorohydrin in the male rat. J Reprod Fertil 1974;38:1-10.
33. Yeung CH, Cooper TG. Study of the role of epididymal α-glucosidase in the fertility of male rats by administration of the enzyme inhibitor castanospermine. J Reprod Fertil 1994;102:401-410.
34. Yeung CH, Oberländer G, Cooper TG. Characterization of the motility of maturing rat spermatozoa by computer-aided objective measurement. J Reprod Fertil 1992;96:427-441.
35. Yeung CH, Oberländer G, Cooper TG. Effects of the male antifertility agent ornidazole on sperm function in vitro and in the female genital tract. J Reprod Fertil 1995;103:257-264.