Prostatitis and male factor infertility: A review of the literature

Current Prostate Reports

Volumn 4, Issue 1, 2006, Pages 45-53

  Engeler, Daniel S ^a   John, Hubert ^b   Maake, Caroline ^b  

^a Kantonsspital St Gallen Klinik fur Urologie   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; ESTRADIOL; MEPARTRICIN; REACTIVE OXYGEN METABOLITE; TAMOXIFEN; TESTOSTERONE;

AUTOIMMUNITY; BACTERIAL INFECTION; CELL PROLIFERATION; CHRONIC PROSTATITIS; DISEASE SEVERITY; HORMONE DEPENDENCE; HUMAN; INCIDENCE; LEUKOCYTOSIS; LEYDIG CELL; MALE INFERTILITY; MEDICAL RESEARCH; NONHUMAN; OXIDATIVE STRESS; PELVIS PAIN SYNDROME; PROSTATITIS; QUALITY OF LIFE; REVIEW; SEMEN ANALYSIS; SEMINAL PLASMA; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; SPERMIOGRAM;

EID: 33750348672     PISSN: 15441865     EISSN: 1544225X     Source Type: Journal    
DOI: 10.1007/s11918-006-0021-0     Document Type: Review

References (103)

1. Collins MM, Stafford RS, O'Leary MP, Barry MJ: How common is prostatitis? A national survey of physician visits. J Urol 1998, 159:1224-1228.
2. Collins MM, Meigs JB, Barry MJ, et al.: Prevalence and correlates of prostatitis in the health professionals follow-up study cohort. J Urol 2002, 167:1363-1366.
3. Nickel JC: Prostatitis: myths and realities. Urology 1998, 51:362-366.
4. McNaughton Collins M, Pontari MA, O'Leary MP, et al.: Quality of life is impaired in men with chronic prostatitis: the Chronic Prostatitis Collaborative Research Network. J Gen Intern Med 2001, 16:656-662.
5. Krieger JN, Nyberg L, Nickel JC: NIH consensus definition and classification of prostatitis. JAMA 1999, 282:236-237.
6. Krieger JN, Ross SO, Deutsch L, Riley DE: The NIH Consensus concept of chronic prostatitis/chronic pelvic pain syndrome compared with traditional concepts of nonbacterial prostatitis and prostatodynia. Curr Urol Rep 2002, 3:301-306.
7. Bostrom K, Andersson L: Creatine phosphokinase relative to acid phosphatase, lactate dehydrogenase, zinc and fructose in human semen with special reference to chronic prostatitis. Scand J Urol Nephrol 1971, 5:123-132.
8. Zlatkov NB, Genov DT: Morphological and biochemical studies of the ejaculate in patients with chronic prostatitis. Dermatol Monatsschr 1975, 161:131-136.
9. Giamarellou H, Tympanidis K, Bitos NA, et al.: Infertility and chronic prostatitis. Andrologia 1984, 16:417-422.
10. Weidner W, Jantos C, Schiefer HG, et al.: Semen parameters in men with and without proven chronic prostatitis. Arch Androl 1991, 26:173-183.
11. Christiansen E, Tollefsrud A, Purvis K: Sperm quality in men with chronic abacterial prostatovesiculitis verified by rectal ultrasonography. Urology 1991, 38:545-549.
12. Pavone-Macaluso M, di Trapani D, Pavone C: Prostatitis, prostatosis and prostalgia. Psychogenic or organic disease? Scand J Urol Nephrol Suppl 1991, 138:77-82.
13. Leib Z, Bartoov B, Eltes F, Servadio C: Reduced semen quality caused by chronic abacterial prostatitis: an enigma or reality? Fertil Steril 1994, 61:1109-1116.
14. Krieger JN, Berger RE, Ross SO, et al.: Seminal fluid findings in men with nonbacterial prostatitis and prostatodynia. J Androl 1996, 17:310-318.
15. Pasqualotto FF, Sharma RK, Potts JM, et al.: Seminal oxidative stress in patients with chronic prostatitis. Urology 2000, 55:881-885. This study shows that seminal ROS levels are increased in patients with chronic abacterial prostatitis.
16. Engeler DS, Hauri D, John H: Impact of prostatitis NIH IIIB (prostatodynia) on ejaculate parameters. Eur Urol 2003, 44:546-548.
17. Menkveld R, Huwe P, Ludwig M, Weidner W: Morphological sperm alternations in different types of prostatitis. Andrologia 2003, 35:288-293. This concise paper shows that chronic prostatitis may have a significant influence on sperm morphology, if strict criteria are used.
18. Ludwig M, Vidal A, Huwe P, et al.: Significance of inflammation on standard semen analysis in chronic prostatitis/chronic pelvic pain syndrome. Andrologia 2003, 35:152-156. This large recent study found no effect of chronic prostatitis (using the NIH classification system) on standard semen parameters.
19. Motrich RD, Maccioni M, Molina R, et al.: Reduced semen quality in chronic prostatitis patients that have cellular autoimmune response to prostate antigens. Hum Reprod 2005, 20:2567-2572. An excellent paper that highlights a new aspect: the possible link between an autoimmune response to prostate antigens in chronic prostatitis and reduced semen quality.
20. Drach GW, Fair WR, Meares EM, Stamey TA: Classification of benign diseases associated with prostatic pain: prostatitis or prostatodynia? J Urol 1978, 120:266.
21. Naslund MJ, Strandberg JD, Coffey DS: The role of androgens and estrogens in the pathogenesis of experimental nonbacterial prostatitis. J Urol 1988, 140:1049-1053.
22. Robinette CL: Sex-hormone-induced inflammation and fibromuscular proliferation in the rat lateral prostate. Prostate 1988, 12:271-286.
23. Stoker TE, Robinette CL, Britt BH, et al.: Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostate. Biol Reprod 1999, 61:1636-1643.
24. Stoker TE, Robinette CL, Cooper RL: Perinatal exposure to estrogenic compounds and the subsequent effects on the prostate of the adult rat: evaluation of inflammation in the ventral and lateral lobes. Reprod Toxicol 1999, 13:463-472.
25. Kwon SM, Kim SI, Chun DC, et al.: Development of rat prostatitis model by oral administration of isoflavone and its characteristics. Yonsei Med J 2001, 42:395-404.
26. Sharma OP, Adlercreutz H, Strandberg JD, et al.: Soy of dietary source plays a preventive role against the pathogenesis of prostatitis in rats. J Steroid Biochem Mol Biol 1992, 43:557-564.
27. Jansson G: Oestrogen-induced enhancement of myeloperoxidase activity in human polymorphonuclear leukocytes-a possible cause of oxidative stress in inflammatory cells. Free Radic Res Commun 1991, 14:195-208.
28. Donadio AC, Gagliano H, Remedi MM, et al.: Time-course study of cellular immune response and testosterone metabolism in an autoimmune model for chronic prostatic inflammation. J Urol 1998, 160:1546-1550.
29. Harris MT, Feldberg RS, Lau KM, et al.: Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate. Prostate 2000, 44:19-25.
30. Gilleran JP, Putz O, Dejong M, et al.: The role of prolactin in the prostatic inflammatory response to neonatal estrogen. Endocrinology 2003, 144:2046-2054.
31. Wilson MJ, Woodson M, Wiehr C, et al.: Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostatitis in the lateral prostate lobe of the Wistar rat. Exp Mol Pathol 2004, 77:7-17.
32. Seethalakshmi L, Bala RS, Malhotra RK, et al.: 17 beta-estradiol induced prostatitis in the rat is an autoimmune disease. J Urol 1996, 156:1838-1842.
33. Tangbanluekal L, Robinette CL: Prolactin mediates estradiol-induced inflammation in the lateral prostate of Wistar rats. Endocrinology 1993, 132:2407-2416.
34. Lundgren R, Holmquist B, Hesselvik M, Muntzing J: Treatment of prostatitis in the rat. Prostate 1984, 5:277-284.
35. You L, Brenneman KA, Heck H: In utero exposure to antiandrogens alters the responsiveness of the prostate to p,ṕ-DDE in adult rats and may induce prostatic inflammation. Toxicol Appl Pharmacol 1999, 161:258-266.
36. Cutolo M, Sulli A, Capellino S, et al.: Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity. Lupus 2004, 13:635-638.
37. Vega D, Depiante-Depaoli M, Pacheco-Rupil B, Nowotny E: Testosterone metabolism in vitro by prostate homogenate from isoimmunized rats. Cell Mol Biol 1983, 29:245-253.
38. Diserio G, Casas AI, Pacheco-Rupil B, Nowotny E: 3 alpha-hydroxysteroid and 3 beta-hydroxysteroid-oxidoreductase activities in vitro from prostate of isoimmunized rats. Cell Mol Biol 1985, 31:81-87.
39. Diserio G, Aragon H, Carrizo A, et al.: 17 beta-hydroxysteroid oxidoreductase activity in rat prostate after autosensitization to male accessory sexual glands. Cell Mol Biol 1986, 32:463-469.
40. Diserio GP, Carrizo AE, Pacheco-Rupil B, Nowotny E: Effect of male accessory glands autoaggression on androgenic cytosolic and nuclear receptors of rat prostate. Cell Mol Biol 1992, 38:201-207.
41. Diserio GP, Nowotny E: Experimental autoimmune prostatitis: dihydrotestosterone influence over the immune response. J Urol 2003, 170:2486-2489.
42. De Rose AF, Gallo F, Giglio M, Carmignani G: Role of mepartricin in category III chronic nonbacterial prostatitis/chronic pelvic pain syndrome: a randomized prospective placebo-controlled trial. Urology 2004, 63:13-16.
43. Yunda IF, Imshinetskaya LP: Testosterone excretion in chronic prostatis. Andrologia 1977, 9:89-94.
44. Dunzendorfer U, Kruschwitz K, Feller H, Milbradt R: Na-tartrate in the treatment of chronic nonbacterial prostatitis. Andrologia 1983, 15:135-140.
45. Bogolyubov VM, Karpukhin IV, Bobkova AS, et al.: Dynamics of spermatogenesis, hormonal and immune response of patients suffering from chronic prostatitis and sterility under bitemporal treatment with an ultra-high frequency electric field. Int Urol Nephrol 1986, 18:89-97.
46. Bouman A, Heineman MJ, Faas MM: Sex hormones and the immune response in humans. Hum Reprod Update 2005, 11:411-423.
47. Maake C, John H: Prostatitis versus pelvic pain syndrome: immunologic studies. Curr Urol Rep 2003, 4:327-334.
48. Pontari MA, Ruggieri MR: Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol 2004, 172:839-845.
49. Hedger MP, Meinhardt A: Cytokines and the immune-testicular axis. J Reprod Immunol 2003, 58:1-26.
50. Diemer T, Huwe P, Ludwig M, et al.: Urogenital infection and sperm motility. Andrologia 2003, 35:283-287.
51. Diemer T, Hales DB, Weidner W: Immune-endocrine interactions and Leydig cell function: the role of cytokines. Andrologia 2003, 35:55-63.
52. Alexander RB, Ponniah S, Hasday J, Hebel JR: Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis/chronic pelvic pain syndrome. Urology 1998, 52:744-749.
53. Nadler RB, Koch AE, Calhoun EA, et al.: IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis. J Urol 2000, 164:214-218.
54. Orhan I, Onur R, Ilhan N, Ardicoglu A: Seminal plasma cytokine levels in the diagnosis of chronic pelvic pain syndrome. Int J Urol 2001, 8:495-499.
55. Shimonovitz S, Barak V, Zacut D, et al.: High concentration of soluble interleukin-2 receptors in ejaculate with low sperm motility. Hum Reprod 1994, 9:653-655.
56. Huleihel M, Lunenfeld E, Horowitz S, et al.: Production of interleukin-1-like molecules by human sperm cells. Fertil Steril 2000, 73:1132-1137.
57. Papadimas J, Goulis DG, Sotiriades A, et al.: Interleukin-1 beta and tumor necrosis factor-alpha in normal/infertile men. Arch Androl 2002, 48:107-113.
58. Gruschwitz MS, Brezinschek R, Brezinschek HP: Cytokine levels in the seminal plasma of infertile males. J Androl 1996, 17:158-163.
59. Dousset B, Hussenet F, Daudin M, et al.: Seminal cytokine concentrations (IL-1beta, IL-2, IL-6, sR IL-2, sR IL-6), semen parameters and blood hormonal status in male infertility. Hum Reprod 1997, 12:1476-1479.
60. Kocak I, Yenisey C, Dundar M, et al.: Relationship between seminal plasma interleukin-6 and tumor necrosis factor alpha levels with semen parameters in fertile and infertile men. Urol Res 2002, 30:263-267.
61. Estrada LS, Champion HC, Wang R, et al.: Effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human sperm motility, viability and motion parameters. Intl Androl 1997, 20:237-242.
62. Drachenberg DE, Elgamal AA, Rowbotham R, et al.: Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer. Prostate 1999, 41:127-133.
63. John H, Barghorn A, Funke G, et al.: Noninflammatory chronic pelvic pain syndrome: immunological study in blood, ejaculate and prostate tissue. Eur Urol 2001, 39:72-78.
64. Paulis G, Conti E, Voliani S, et al.: Evaluation of the cytokines in genital secretions of patients with chronic prostatitis. Arch Ital Urol Androl 2003, 75:179-186.
65. Naz RK, Kaplan P: Increased levels of interleukin-6 in seminal plasma of infertile men. J Androl 1994, 15:220-227.
66. Paradisi R, Mancini R, Bellavia E, et al.: T-helper 2 type cytokine and soluble interleukin-2 receptor levels in seminal plasma of infertile men. Am J Reprod Immunol 1997, 38:94-99.
67. Furuya Y, Akashi T, Fuse H: Soluble Fas and interleukin-6 and interleukin-8 levels in seminal plasma of infertile men. Arch Androl 2003, 49:449-452.
68. Camejo MI: Relation between immunosuppressive PGE(2) and IL-10 to pro-inflammatory IL-6 in seminal plasma of infertile and fertile men. Arch Androl 2003, 49:111-116.
69. Naz RK, Kaplan P: Interleukin-6 enhances the fertilizing capacity of human sperm by increasing capacitation and acrosome reaction. J Androl 1994, 15:228-233.
70. Miller LJ, Fischer KA, Goralnick SJ, et al.: Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome. J Urol 2002, 167:753-756.
71. Paradisi R, Capelli M, Mandini M, et al.: Increased levels of interferon-gamma in seminal plasma of infertile men. Andrologia 1996, 28:157-161.
72. Sikka SC, Champion HC, Bivalacqua TJ, et al.: Role of genitourinary inflammation in infertility: synergistic effect of lipopolysaccharide and interferon-gamma on human spermatozoa. Int J Androl 2001, 24:136-141.
73. Fujisawa M, Fujioka H, Tatsumi N, et al.: Levels of interferon alpha and gamma in seminal plasma of normozoospermic, oligozoospermic, and azoospermic men. Arch Androl 1998, 40:211-214.
74. Ponniah S, Arah I, Alexander RB: PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome. Prostate 2000, 44:49-54.
75. Batstone GR, Doble A, Gaston JS: Autoimmune T cell responses to seminal plasma in chronic pelvic pain syndrome (CPPS). Clin Exp Immunol 2002, 128:302-307.
76. Motrich RD, Maccioni M, Molina R, et al.: Presence of INFgamma-secreting lymphocytes specific to prostate antigens in a group of chronic prostatitis patients. Clin Immunol 2005, 116:149-157.
77. Munoz MG, Witkin SS: Autoimmunity to spermatozoa, asymptomatic Chlamydia trachomatis genital tract infection and gamma delta T lymphocytes in seminal fluid from the male partners of couples with unexplained infertility. Hum Reprod 1995, 10:1070-1074.
78. Witkin SS, Zelikovsky G: Immunosuppression and sperm antibody formation in men with prostatitis. J Clin Lab Immunol 1986, 21:7-10.
79. Jarow JP, Kirkland JA, Assimos DG: Association of antisperm antibodies with chronic nonbacterial prostatitis. Urology 1990, 36:154-156.
80. Witkin SS, Kligman I, Bongiovanni AM: Relationship between an asymptomatic male genital tract exposure to Chlamydia trachomatis and an autoimmune response to spermatozoa. Hum Reprod 1995, 10:2952-2955.
81. Eggert-Kruse W, Rohr G, Demirakca T, et al.: Chlamydial serology in 1303 asymptomatic subfertile couples. Hum Reprod 1997, 12:1464-1475.
82. Weidner W, Floren E, Zimmermann O, et al.: Chlamydial antibodies in semen: search for "silent" chlamydial infections in asymptomatic andrological patients. Infection 1996, 24:309-313.
83. Weidner W, Krause W, Ludwig M: Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitis. Hum Reprod Update 1999, 5:421-432.
84. Ludwig M, Kummel C, Schroeder-Printzen I, et al.: Evaluation of seminal plasma parameters in patients with chronic prostatitis or leukocytospermia. Andrologia 1998, 30(Suppl 1):41-47.
85. Wolff H: The biologic significance of white blood cells in semen. Fertil Steril 1995, 63:1143-1157.
86. Branigan EF, Muller CH: Efficacy of treatment and recurrence rate of leukocytospermia in infertile men with prostatitis. Fertil Steril 1994, 62:580-584.
87. Aitken RJ, Baker HW: Seminal leukocytes: passengers, terrorists or good Samaritans? Hum Reprod 1995, 10:1736-1739.
88. Ochsendorf FR: Infections in the male genital tract and reactive oxygen species. Hum Reprod Update 1999, 5:399-420.
89. Aitken RJ, Buckingham D, Harkiss D: Use of a xanthine oxidase free radical generating system to investigate the cytotoxic effects of reactive oxygen species on human spermatozoa. J Reprod Fertil 1993, 97:441-450.
90. Alkan I, Simsek F, Haklar G, et al.: Reactive oxygen species production by the spermatozoa of patients with idiopathic infertility: relationship to seminal plasma antioxidants. J Urol 1997, 157:140-143.
91. Sharma RK, Pasqualotto FF, Nelson DR, et al.: The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Hum Reprod 1999, 14:2801-2807.
92. Sharma RK, Agarwal A: Role of reactive oxygen species in male infertility. Urology 1996, 48:835-850.
93. D'Agata R, Vicari E, Moncada ML, et al.: Generation of reactive oxygen species in subgroups of infertile men. Int J Androl 1990, 13:344-351.
94. Potts JM, Sharma R, Pasqualotto F, et al.: Association of ureaplasma urealyticum with abnormal reactive oxygen species levels and absence of leukocytospermia. J Urol 2000, 163:1775-1778.
95. Potts JM, Pasqualotto FF: Seminal oxidative stress in patients with chronic prostatitis. Andrologia 2003, 35:304-308. An informative overview of the present state of knowledge on the role of ROS in chronic prostatitis.
96. Krieger JN, Ross SO, Riley DE: Chronic prostatitis: epidemiology and role of infection. Urology 2002, 60:8-12.
97. Diemer T, Huwe P, Michelmann HW, et al.: Escherichia coli-induced alterations of human spermatozoa. An electron microscopy analysis. Int J Androl 2000, 23:178-186.
98. Kohn FM, Erdmann I, Oeda T, et al.: Influence of urogenital infections on sperm functions. Andrologia 1998, 30(Suppl 1):73-80.
99. Krause W, Bohring C: Male infertility and genital chlamydial infection: victim or perpetrator? Andrologia 2003, 35:209-216.
100. Comhaire FH, Rowe PJ, Farley TM: The effect of doxycycline in infertile couples with male accessory gland infection: a double-blind prospective study. Int J Androl 1986, 9:91-98.
101. Muller A, Mulhall JP: Sexual dysfunction in the patient with prostatitis. Curr Opin Urol 2005, 15:404-409.
102. Zaslau S, Riggs D, Jackson B, et al.: Chronic prostatitis is an independent risk factor for erectile dysfunction. J Urol 2005, 173:28-29.
103. Tripp D, Nickel JC, McNaughton-Collins M, et al.: Coping with depression in chronic prostatitits/chronic pelvic pain syndrome: a key to treatment of the pain. AUA 2005, in press.