Time-course study of cellular immune response and testosterone metabolism in an autoimmune model for chronic prostatic inflammation

Journal of Urology

Volumn 160, Issue 4, 1998, Pages 1546-1550

  Donadio, A C ^a   Gagliano, H ^a   Remedi, M M ^a   Nowotny, E ^a   Depiante Depaoli, M ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Autoimmunity; Immune response; Prostatitis; Rat; Testosterone metabolism

Indexed keywords

ANDROSTANEDIOL; ANDROSTANOLONE; ANDROSTENEDIONE; ANDROSTERONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ACCESSORY SEX GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELLULAR IMMUNITY; CHRONIC INFLAMMATION; CHRONIC PROSTATITIS; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; ENDOCRINE CELL; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; TESTOSTERONE METABOLISM; THIN LAYER CHROMATOGRAPHY;

EID: 0032323479     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)62610-7     Document Type: Article

References (27)

1. Meares, E. M.: Prostatitis and related disorders. In: Cambell's Urology, 5th. Ed. Edited by P. C. Walsh, R. F. Gittes, A. D. Perlmutter and T. A. Stamey. Philadelphia: W. B. Saunders Co., pp. 868-887, 1986.
2. Stanislavov, R., Tsvetkov, D. and Tsvetkova, P.: Immunological studies of patients with chronic nonspecific prostatitis and infertility. Akush. Ginekol. (Sofia), 29: 57, 1990.
3. Doble, A., Walker, M. M., Harris, J. R. W., Taylor-Robinson, D. and Witherow, R. O'N.: Intraprostatic antibody deposition in chronic abacterial prostatitis. Br. J. Urol., 65: 598, 1990.
4. Pacheco-Rupil, B., Depiante-Depaoli, M., Romero, O., Romero, M. and Yantorno, C.: Experimental autoimmune damage to rat male accessory glands. Am. J. Reprod. Immunol., 1: 255, 1981.
5. Depiante-Depaoli, M., Pacheco-Rupil, B., Britos, S. and Casas, A.: Experimental autoimmune damage to rat male accessory glands. I. Transfer of autoimmune response by spleen cells. Am. J. Reprod. Immunol., 5: 9, 1984.
6. Pacheco-Rupil, B., Depiante-Depaoli, M. and Casadio, B.: Experimental autoimmune damage to rat male accessory glands. II. T-cell requirement in adoptive transfer of specific tissue damage. Am. J. Reprod. Immunol., 5: 15, 1984.
7. Depiante-Depaoli, M. and Pacheco-Rupil, B.: Experimental autoimmunity to rat male accessory glands (MAG). Circulating antibodies, immunoglobulins bound target glands and immunoglobulins-secreting cells. Am. J. Reprod. Immunol., 7: 32, 1987.
8. Depiante-Depaoli, M., Hliba, E. and Pacheco-Rupil, B.: Experimental autoimmunity against rat male accessory glands. Correlation between specific tissue damage and reactivity of lymphocytes from thymus, bone marrow, blood, spleen and lymph nodes. Medicina, 47: 145, 1987.
9. Casas-Ingaramo, A., Depiante-Depaoli, M. and Pacheco-Rupil, B.: Activation of cytotoxic cells by syngeneic prostate antigens in experimental autoimmune vesiculo-prostatitis. Autoimmunity, 9: 151, 1991.
10. Doble, A., Thomas, B. J., Walker, M. M., Harris, J. R. W., Witherow, R. O'N. and Taylor-Robinson, D.: The role of Chlamydia trachomatis in chronic abacterial prostatitis: a study using ultrasound guided biopsy. J. Urol., 141: 332, 1989.
11. Orsilles, M. A., Pacheco-Rupil, B. and Depiante-Depaoli, M.: Experimental autoimmune prostatitis (EAP): enhanced release of reactive oxygen intermediates (ROI) in peritoneal macrophages. Autoimmunity, 16: 201, 1993.
12. Orsilles, M. A., Donadio, A. C. and Depiante-Depaoli, M.: Time course of reactive oxygen intermediates release and histopathological findings during experimental autoimmune prostatitis development. Prostate, 27: 50, 1995.
13. Orsilles, M. A. and Depiante-Depaoli, M.: Production of reactive nitrogen intermediates (RNI) by peritoneal macrophages from rats with experimental autoimmune prostatitis (EAP). Inflammation, 19: 415, 1995.
14. Donadio, A. C. and Depiante-Depaoli, M.: Inflammatory cells and MHC class II antigens expression in prostate during time-course experimental autoimmune prostatitis (EAP) development. Clin. Immunol. Immunopathol., 85: 158, 1997.
15. Farnsworth, W. E. and Brown, J. R.: Testosterone metabolism in the prostate. In: Biology of the Prostate and Related Tissues. Edited by P. E. Vollmer, Bethesda, Maryland: NCI Monograph, 12: 323, 1963.
16. Bruchovsky, N.: Comparison of the metabolites formed in rat prostate following the in vivo administration of seven natural androgens. Endocrinology, 89: 1212, 1971.
17. Wilson, J. D. and Gloyna, R. E.: The intranuclear metabolism of testosterone in the accessory organs of reproduction. Recent Prog. Horm. Res., 26: 309, 1970.
18. Benson, J. L. and Niederkorn, J. Y.: Immune privilege in the anterior chamber of the eye. Alloantigens and tumor-specific antigens presented into the anterior chamber simultaneously induce suppression and activation of delayed hypersensitivity to the respective antigens. Immunology, 77: 189, 1992.
19. Genti-Raimondi, S., Nowotny, E., Galmarini, M. and Yantorno, C.: Testosterone metabolism in vitro by male sexual accessory glands from normal and autoimmunized rabbits. Acta Physiol. Latinoam., 29: 107, 1979.
20. Bruchovsky, N. and Lieskovsky, G.: Increased ratio of 5α-reductase: 3α(β)-hydroxysteroid dehydrogenase activities in the hyperplastic human prostate. J. Endocrinol., 80: 289, 1979.
21. Weigent, D. A. and Blalock, J. E.: Associations between the neuroendocrine and immune systems. J. Leukoc. Biol., 58: 137, 1995.
22. Mandrup-Poulsen, T., Zumsteg, U., Reimers, J., Pociot, F., Merch, L., Helqvist, S., Dinarello, C. A. and Nerup, J.: Involvement of interleukin-1 and interleukin-1 antagonist in pancreatic β-cell destruction in insulin-dependent diabetes mellitus. Cytokine, 5: 185, 1993.
23. Enamoto, T., Sugawa, H., Kosugi, S., Inove, D., Mari, T. and Imura, H.: Prolonged effects of recombinant human interleukin-1α on mouse thyroid function. Endocrinology, 127: 2322, 1990.
24. Schröder, F. H.: 5α-Reductase inhibitors and prostatic disease. Clinical Endocrinology, 41: 139, 1994.
25. Orsilles, M. A. and Depiante-Depaoli, M.: Oxidative stress-related parameters in prostate of rats with experimental autoimmune prostatitis. Prostate, 34: 270, 1998.
26. Mielsel, R., Ulbrich, N., Kroger, N. and Mitchison, A.: Assessment of collagen type II induced arthritis in mice by whole blood chemiluminescense. Autoimmunity, 19: 153, 1995.
27. Mandrup-Poulsen, T., Nerup, J., Reimers, J. I., Pociot, F., Sandersen, H. U., Karlsen, A., Bjerre, U. and Bergholdt, R.: Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases. Eur. J. Endocrinol., 134: 21, 1996.