Structure of the Ctr1 copper trans'PORE'ter reveals novel architecture

Trends in Biochemical Sciences

Volumn 31, Issue 11, 2006, Pages 604-607

  Nose, Yasuhiro ^a   Rees, Erin M ^a   Thiele, Dennis J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; COPPER ION; COPPER TRANSPORTER CTR1 PROTEIN; FREE RADICAL; UNCLASSIFIED DRUG;

CELL MEMBRANE; COPPER METABOLISM; CRYSTALLOGRAPHY; DETOXIFICATION; ELECTRON MICROSCOPY; EUKARYOTIC CELL; HOMEOSTASIS; HUMAN; IRON METABOLISM; MEMBRANE TRANSPORT; MITOCHONDRIAL RESPIRATION; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SHORT SURVEY; TRANSPORT KINETICS;

ANIMALS; BIOLOGICAL TRANSPORT; BIOPOLYMERS; CATION TRANSPORT PROTEINS; COPPER; CRYSTALLOGRAPHY; HUMANS; MICE; MICROSCOPY, ELECTRON; PROTEIN CONFORMATION;

EID: 33750326197     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2006.09.003     Document Type: Short Survey

References (20)

1. Prohaska J.R., and Gybina A.A. Intracellular copper transport in mammals. J. Nutr. 134 (2004) 1003-1006
2. Puig S., and Thiele D.J. Molecular mechanisms of copper uptake and distribution. Curr. Opin. Chem. Biol. 6 (2002) 171-180
3. Dancis A., et al. Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell 76 (1994) 393-402
4. Zhou B., and Gitschier J. hCTR1: a human gene for copper uptake identified by complementation in yeast. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 7481-7486
5. Aller S.G., and Unger V.M. Projection structure of the human copper transporter CTR1 at 6-Å resolution reveals a compact trimer with a novel channel-like architecture. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 3627-3632
6. Kuo Y.M., et al. The copper transporter CTR1 provides an essential function in mammalian embryonic development. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 6836-6841
7. Lee J., et al. Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 6842-6847
8. Lee J., et al. Characterization of mouse embryonic cells deficient in the Ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. J. Biol. Chem. 277 (2002) 40253-40259
9. Ishida, et al. Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 14298-14302
10. Hassett R., and Kosman D.J. Evidence for Cu(II) reduction as a component of copper uptake by Saccharomyces cerevisiae. J. Biol. Chem. 270 (1995) 128-134
11. Lee J., et al. Biochemical characterization of the human copper transporter Ctr1. J. Biol. Chem. 277 (2002) 4380-4387
12. Puig S., et al. Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. J. Biol. Chem. 277 (2002) 26021-26030
13. Gunshin H., et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
14. Eisses J.F., and Kaplan J.H. The mechanism of copper uptake mediated by human CTR1. J. Biol. Chem. 280 (2005) 37159-37168
15. Dancis A., et al. The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. J. Biol. Chem. 269 (1994) 25660-25667
16. Peña M.M.O., et al. Characterization of the Saccharomyces cerevisiae high affinity copper transporter Ctr3. J. Biol. Chem. 275 (2000) 33244-33251
17. Klomp A.E.M., et al. The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself. Biochem. J. 370 (2003) 881-889
18. Aller S.G., et al. Eukaryotic CTR copper uptake transporters require two faces of the third transmembrane domain for helix packing, oligomerization, and function. J. Biol. Chem. 279 (2004) 53435-53441
19. Jiang J., et al. A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination. Inorg. Chem. 44 (2005) 9787-9794
20. Xiao Z., et al. C-terminal domain of the membrane copper transporter Ctr1 from Saccharomyces cerevisiae binds four Cu(I) ions as a cuprous-thiolate polynuclear cluster: sub-femtomolar Cu(I) affinity of three proteins involved in copper trafficking. J. Am. Chem. Soc. 126 (2004) 3081-3090