Novel Drosophila two-pore domain K+ channels: Rescue of channel function by heteromeric assembly

European Journal of Neuroscience

Volumn 24, Issue 8, 2006, Pages 2264-2274

  Döring, Frank ^a   Scholz, Henrike ^b   Kühnlein, Ronald P ^c   Karschin, Andreas ^a   Wischmeyer, Erhard ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Background current; Local anesthetics; Olfactory learning; pH sensor; Potassium channel genes

Indexed keywords

ALANINE; COMPLEMENTARY DNA; GLYCINE DERIVATIVE; GLYCYLTYROSYLGLYCINE; HISTIDINE; ISOPROTEIN; LOCAL ANESTHETIC AGENT; METHIONINE; POTASSIUM CHANNEL; PROTEIN SUBUNIT; PROTEIN TWIK RELATED ACID SENSITIVE POTASSIUM CHANNEL 6; PROTEIN TWIK RELATED ACID SENSITIVE POTASSIUM CHANNEL 7; PROTON; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTENNA; ARTICLE; BRAIN; CHANNEL GATING; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EXTRACELLULAR SPACE; GENE IDENTIFICATION; GENE ISOLATION; GENE STRUCTURE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENOME; IN SITU HYBRIDIZATION; INSECT CELL; KINETICS; MUTATIONAL ANALYSIS; NONHUMAN; NORTHERN BLOTTING; PH MEASUREMENT; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE HOMOLOGY;

EID: 33750308097     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2006.05102.x     Document Type: Article

References (51)

1. Adams, M.D., Celniker, S.E., Holt, R.A. et al. (2000) The genome sequence of Drosophila melanogaster. Science, 287, 2185-2195.
2. + channel family. Pflügers Arch., 442, 828-833.
3. + channels. Mol. Interv., 3, 205-219.
4. + (TASK) channels containing TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits. J. Neurosci., 24, 6693-6702.
5. + channels: contribution from genetic model organisms. Trends Pharmacol. Sci., 26, 361-367.
6. + channel subunit. Proc. Natl Acad. Sci. U.S.A., 93, 14 193-14 198.
7. Czirják, G. & Enyedi, P. (2002) Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunit. J. Biol. Chem., 277, 5426-5432.
8. Davis, R.L. (2005) Olfactory memory formation in Drosophila: from molecular to systems neuroscience. Annu. Rev. Neurosci., 28, 275-302.
9. + (Kir) channels in Drosophila. A crucial role of cellular milieu factors for Kir channel function. J. Biol. Chem., 277, 25 554-25 561.
10. + conduction and selectivity. Science, 280, 69-77.
11. Drysdale, R.A., Crosby, M.A. & the FlyBase Consortium (2005) FlyBase: genes and gene models. Nucl. Acids Res., 33, D390-D395. http://flybase.org/.
12. + channel to sense external variations near physiological pH. EMBO J., 17, 5464-5471.
13. Goldstein, S.A.N., Price, L.A., Rosenthal, D.N. & Pausch, M.A. (1996) ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. U.S.A., 93, 13 256-13 261.
14. Goldstein, S.A.N., Bockenhauer, D., O'Kelly, I. & Zilberberg, N. (2001) Potassium channels and the KCNK family of two-P-domain subunits. Nat. Rev. Neurosci., 2, 175-184.
15. Hawkins, R.D., Kandel, E.R. & Siegelbaum, S.A. (1993) Learning to modulate transmitter release: themes and variations in synaptic plasticity. Annu. Rev. Neurosci., 16, 625-665.
16. Horton, R.M., Hunt, H.D., Ho, S.N., Pullen, J.K. & Pease, L.R. (1989) Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene, 77, 61-68.
17. Kang, D., Han, J., Talley, E.M., Bayliss, D.A. & Kim, D. (2003) Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells. J. Physiol., 554, 64-77.
18. + channel subunit, TASK-5, associated with the central auditory nervous system. Mol. Cell. Neurosci., 18, 632-648.
19. + channel family. J. Biol. Chem., 275, 9340-9347.
20. Kindler, C.H. & Yost, C.S. (2005) Two-pore domain potassium channels: new sites of local anesthetic action and toxicity. Region. Anesth., 30, 260-274.
21. +-channel proteins. Nature, 374, 135-141.
22. Kunkel, M.T., Duncan, B.J., Thomas, J.H. & Salkoff, L. (2000) Mutants of temperature-sensitive two-P domain potassium channel. J. Neurosci., 20, 7517-7524.
23. Leonoudakis, D., Gray, A.T., Winegar, B.D., Kindler, C.H., Harada, M., Taylor, D.M., Chavaz, R.A., Forsayeth, J.R. & Yost, C.S. (1998) An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum. J. Neurosci., 18, 868-877.
24. Littleton, J.T. & Ganetzky, B. (2000) Ion channels and synaptic organisation: Analysis of the Drosophila genome. Neuron, 26, 35-43.
25. Lopes, C.E.B., Gallagher, P.G., Buck, M.E., Butler, M.H. & Goldstein, S.A.N. (2000) Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. J. Biol. Chem., 275, 19 969-16 978.
26. Lopes, C.M.B., Zilberberg, N. & Goldstein, S.A.N. (2001) Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers. J. Biol. Chem., 276, 24 449-244 520.
27. + channel TASK-1. EMBO J., 20, 47-54.
28. Meadows, H.J. & Randall, A.D. (2001) Functional characterization of human TASK-3, an acid-sensitive two-pore domain potassium channel. Neuropharmacology, 40, 551-559.
29. Medhurst, A.D., Rennie, G., Chapman, C.G., Meadows, H., Duckworth, M.D., Kelsell, R.E., Gloger, I.I. & Pangalos, M.N. (2001) Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Mol. Brain Res., 86, 101-114.
30. Methfessel, C., Witzemann, V., Takashi, T., Mishina, M., Numa, S. & Sakmann, B. (1986) Patch-clamp measurements on Xenopus oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflügers Arch., 407, 577-588.
31. + channel, TASK2. Proc. Natl Acad. Sci. U.S.A., 102, 16 102-16 106.
32. + channels. Trends Neurosci., 24, 339-346.
33. + channels. Nat. Neurosci., 2, 422-426.
34. + channel that coordinates muscle contraction in Caenorhabditis elegans. J. Neurosci., 27, 9133-9145.
35. + channel. J. Biol. Chem., 275, 16 650-16 657.
36. + channels. J. Biol. Chem., 276, 7302-7311.
37. + channel K2P1. Cell, 121, 37-47.
38. + channel from human kidney. J. Biol. Chem., 273, 30 863-30 869.
39. Salinas, M., Reyes, R., Lesage, F., Fosset, M., Heurteaux, C., Romey, G. & Lazdunski, M. (1999) Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. J. Biol. Chem., 274, 11 751-11 760.
40. Salkoff, L., Butler, A., Fawcett, G., Kunkel, M., McArdale, C., Paz-Y-Mino, G., Nonet, M., Walton, N., Wang, Z.-W., Yuan, A. & Wei, A. (2001) Evolution tunes the excitability of individual neurons. Neuroscience, 103, 853-859.
41. + channel, TRESK, is localized in the spinal cord. J. Biol. Chem., 278, 27 406-27 412.
42. Schmidt, A., Hollmann, A. & Schäfer, U. (1996) A newly identified minute locus, M(2)32D, encodes the ribosomal protein L9 in Drosophila melanogaster. Mol. Gen. Genet., 251, 381-387.
43. Schneider, I. (1972) Cell lines derived from late embryonic stages of Drosophila melanogaster. J. Embryol. Exp. Morophol., 27, 363-365.
44. + channels in Aplysia sensory neurons in cell-free membrane patches. Nature, 313, 392-395.
45. + channels in Aplysia sensory neurons. Nature, 299, 413-417.
46. Talley, E.M. & Bayliss, D.A. (2002) Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels. J. Biol. Chem., 277, 17 733-17 742.
47. Tautz, D. & Pfeifle, C. (1989) A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma, 98, 81-85.
48. Towers, P.R. & Sattelle, D.B. (2002) A Drosophila melanogaster cell line (S2) facilitates post-genome functional analysis of receptors and ion channels. Bioessays, 24, 1066-1073.
49. Wang, H.S., Pan, Z., Shi, W., Brown, B.S., Wymore, R.S., Cohen, I.S., Dixon, J.E. & MacKinnon, D. (1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science, 282, 1890-1893.
50. + channels in Aplysia neurons. Brain Res., 807, 255-262.
51. + channels. Mol. Cell. Neurosci., 9, 194-206.