The CR4 region of EBNA2 confers viability of Epstein-Barr virus-transformed B cells by CBF1-independent signalling

Journal of General Virology

Volumn 87, Issue 11, 2006, Pages 3169-3176

  Grabusic, Kristina ^a,c   Maier, Sabine ^a   Hartmann, Andrea ^a   Mantik, Anja ^a   Hammerschmidt, Wolfgang ^b   Kempkes, Bettina ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b Department of Gene Vectors ^*  (Germany)

^c UNIVERSITY OF RIJEKA   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; EPSTEIN BARR VIRUS NUCLEAR ANTIGEN 2; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CELL CULTURE; CELL DEATH; CELL DENSITY; CELL DIVISION; CELL VIABILITY; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE DELETION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; LYMPHOCYTE SUBPOPULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS CELL TRANSFORMATION; VIRUS INFECTION; VIRUS MUTANT; WILD TYPE;

B-LYMPHOCYTES; CELL SURVIVAL; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; CONSERVED SEQUENCE; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; GENE DELETION; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; SIGNAL TRANSDUCTION;

HUMAN HERPESVIRUS 4;

EID: 33750238371     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.82105-0     Document Type: Article

References (37)

1. Barth, S., Liss, M., Voss, M. D., Dobner, T., Fischer, U., Meister, G. & Grasser, F. A. (2003). Epstein-Barr virus nuclear antigen 2 binds via its methylated arginine-glycine repeat to the survival motor neuron protein. J Virol 77, 5008-5013.
2. Ben-Bassat, H., Goldblum, N., Mitrani, S. & 7 other authors (1977). Establishment in continuous culture of a new type of lymphocyte from a 'Burkitt like' malignant lymphoma (line DG-75). Int J Cancer 19, 27-33.
3. R cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant. Gene 158, 9-14.
4. Cohen, J. I., Wang, F., Mannick, J. & Kieff, E. (1989). Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation. Proc Natl Acad Sci U S A 86, 9558-9562.
5. Cohen, J. I., Wang, F. & Kieff, E. (1991). Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation. J Virol 65, 2545-2554.
6. Datsenko, K. A. & Wanner, B. L. (2000). One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci U S A 97, 6640-6645.
7. Delecluse, H. J., Hilsendegen, T., Pich, D., Zeidler, R. & Hammerschmidt, W. (1998). Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cells. Proc Natl Acad Sci U S A 95, 8245-8250.
8. 32P-based hybridizations. Anal Biochem 210, 235-244.
9. Farrell, C. J., Lee, J. M., Shin, E. C., Cebrat, M., Cole, P. A. & Hayward, S. D. (2004). Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide. Proc Natl Acad Sci U S A 101, 4625-4630.
10. Graham, F. L., Smiley, J., Russell, W. C. & Nairn, R. (1977). Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 36, 59-74.
11. Hammerschmidt, W. & Sugden, B. (1989). Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes. Nature 340, 393-397.
12. Henkel, T., Ling, P. D., Hayward, S. D. & Peterson, M. G. (1994). Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa. Science 265, 92-95.
13. Horan, P. K., Melnicoff, M. J., Jensen, B. D. & Slezak, S. E. (1990). Fluorescent cell labeling for in vivo and in vitro cell tracking. Methods Cell Biol 33, 469-490.
14. Hsieh, J. J. & Hayward, S. D. (1995). Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2. Science 268, 560-563.
15. Hsieh, J. J., Zhou, S., Chen, L., Young, D. B. & Hayward, S. D. (1999). CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A 96, 23-28.
16. Janz, A., Oezel, M., Kurzeder, C., Mautner, J., Pich, D., Kost, M., Hammerschmidt, W. & Delecluse, H. J. (2000). Infectious Epstein-Barr virus lacking major glycoprotein BLLF1 (gp350/220) demonstrates the existence of additional viral ligands. J Virol 74, 10142-10152.
17. Kao, H. Y., Ordentlich, P., Koyano-Nakagawa, N., Tang, Z., Downes, M., Kintner, C. R., Evans, R. M. & Kadesch, T. (1998). A histone deacetylase corepressor complex regulates the notch signal transduction pathway. Genes Dev 12, 2269-2277.
18. Kavathas, P., Bach, F. H. & DeMars, R. (1980). Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in lymphoblastoid cells. Proc Natl Acad Sci U S A 77, 4251-4255.
19. Kelly, G. L., Milner, A. E., Tierney, R. J., Croom-Carter, D. S., Altmann, M., Hammerschmidt, W., Bell, A. I. & Rickinson, A. B. (2005). Epstein-Barr virus nuclear antigen 2 (EBNA2) gene deletion is consistently linked with EBNA3A, -3B, and -3C expression in Burkitt's lymphoma cells and with increased resistance to apoptosis. J Virol 79, 10709-10717.
20. Kempkes, B., Spitkovsky, D., Jansen-Durr, P., Ellwart, J. W., Kremmer, E., Delecluse, H. J., Rottenberger, C., Bornkamm, G. W. & Hammerschmidt, W. (1995). B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2. EMBO J 14, 88-96.
21. Kolluri, S. K., Bruey-Sedano, N., Cao, X., Lin, B., Lin, F., Han, Y. H., Dawson, M. I. & Zhang, X. K. (2003). Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. Mol Cell Biol 23, 8651-8667.
22. Lee, J. M., Lee, K. H., Weidner, M., Osborne, B. A. & Hayward, S. D. (2002). Epstein-Barr virus EBNA2 blocks Nur77-mediated apoptosis. Proc Natl Acad Sci U S A 99, 11878-11883.
23. Lee, J. M., Lee, K. H., Farrell, C. J., Ling, P. D., Kempkes, B., Park, J. H. & Hayward, S. D. (2004). EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli. J Virol 78, 12694-12697.
24. Lin, B., Kolluri, S. K., Lin, F., Liu, W., Han, Y. H., Cao, X., Dawson, M. I., Reed, J. C. & Zhang, X. K. (2004). Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/ TR3. Cell 116, 527-540.
25. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55-63.
26. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. & Riccardi, C. (1991). A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139, 271-279.
27. Peng, R., Gordadze, A. V., Fuentes Panana, E. M., Wang, F., Zong, J., Hayward, G. S., Tan, J. & Ling, P. D. (2000). Sequence and functional analysis of EBNA-LP and EBNA2 proteins from nonhuman primate lymphocryptoviruses. J Virol 74, 379-389.
28. Pulvertaft, J. V. (1964). Cytology of Burkitt's Tumour (African Lymphoma). Lancet 39, 238-240.
29. Sinclair, A. J., Palmero, I., Peters, G. & Farrell, P. J. (1994). EBNA-2 and EBNA-LP cooperate to cause G0 to G1 transition during immortalization of resting human B lymphocytes by Epstein-Barr virus. EMBO J 13, 3321-3328.
30. Thorley-Lawson, D. A. (2001). Epstein-Barr virus: exploiting the immune system. Nat Rev Immunol 1, 75-82.
31. Tong, X., Drapkin, R., Reinberg, D. & Kieff, E. (1995a). The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2. Proc Natl Acad Sci U S A 92, 3259-3263.
32. Tong, X., Drapkin, R., Yalamanchili, R., Mosialos, G. & Kieff, E. (1995b). The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. Mol Cell Biol 15, 4735-4744.
33. Tong, X., Wang, F., Thut, C. J. & Kieff, E. (1995c). The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPA70 but not with TATA-binding protein. J Virol 69, 5805-588.
34. Wang, L., Grossman, S. R. & Kieff, E. (2000). Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter. Proc Natl Acad Sci U S A 97, 430-4035.
35. Yalamanchili, R., Tong, X., Grossman, S., Johannsen, E., Mosialos, G. & Kieff, E. (1994). Genetic and biochemical evidence that EBNA 2 interaction with a 63-kDa cellular GTG-binding protein is essential for B lymphocyte growth transformation by EBV. Virology 204, 634-641.
36. Zimber-Strobl, U. & Strobl, L. J. (2001). EBNA2 and notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes. Semin Cancer Biol 11, 423-434.
37. Zimber-Strobl, U., Strobl, L. J., Meitinger, C., Hinrichs, R., Sakai, T., Furukawa, T., Honjo, T. & Bornkamm, G. W. (1994). Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless. EMBO J 13, 4973-4982.