Excessive liver oxidant stress causes mortality in response to burn injury combined with endotoxin and is prevented with antioxidants

Journal of Burn Care and Rehabilitation

Volumn 18, Issue 3, 1997, Pages 187-192

  LaLonde, C ^a   Nayak, U ^a   Hennigan, J ^a   Demling, R H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; ASCORBIC ACID; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLUTATHIONE;

ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BURN; CONTROLLED STUDY; ENDOTOXEMIA; LIVER METABOLISM; MORTALITY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SEPSIS; TREATMENT OUTCOME;

ACETYLCYSTEINE; ADENINE NUCLEOTIDES; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BURNS; CATALASE; ENDOTOXEMIA; ENERGY METABOLISM; GLUTATHIONE; LIVER; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN E;

EID: 0030998481     PISSN: 02738481     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004630-199705000-00002     Document Type: Article

References (48)

1. Winchurch RA, Thupari JN, Munster AM. Endotoxemia in burn patients: levels of circulating endotoxins are related to burn size. Surgery 1987;102:808-12.
2. Till GO, Guilds LS, Mahrougui M, Friedl HP, et al. Role of xanthine oxidase in thermal injury to skin. Am J Pathol 1989; 135:203-17.
3. Oldham K, Guice K, Till G, et al. Activation of complement by hydroxyl radical in thermal injury. Surgery 1988;104:272-9.
4. LaLonde C, Knox J, Youn Y, Demling RH. Relationship between hepatic blood flow and tissue liver lipid peroxidation in the early postburn period. Crit Care Med 1992;20:789-96.
5. Till GO, Hatherill JR, Toutellotte WW, et al. Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical. Am J Pathol 1985;119: 376-84.
6. Daryani R, LaLonde C, Zhu D, Weidner M, et al. Effect of endotoxin and a body burn on lung and liver lipid peroxidation and catalase activity. J Trauma 1990;30:1330-4.
7. Demling RH, LaLonde C. Early burn excision attenuates the post burn lung and systemic response to endotoxemia. Surgery 1990;108:28-35.
8. Demling RH, LaLonde C. Effect of a body burn on endotoxin-induced lipid peroxidation: comparison with physiologic and histologic changes. Surgery 1990;107:669-76.
9. Demling RH, LaLonde C. Early post burn lipid peroxidation: effect of ibuprofen and allopurinol. Surgery 1990;1007:85-93.
10. Till GO, Friedl HP, Ward PA. Antioxidant treatment in experimental thermal injury. Adv Exp Med Biol 1990;264: 543-9.
11. Demling RH, LaLonde C, Knox J, Youn YK, et al. Fluid resuscitation with deferoxamine presents systemic burn-induced oxidant injury. J Trauma 1991;31:538-43.
12. Demling RH, LaLonde C. Identification and modifications of the pulmonary and systemic inflammatory and biochemical changes caused by a skin burn. J Trauma 1990;30:S57-62.
13. Oldham KT, Guise KS, Till GO, Ward PA. Antioxidant treatment in experimental thermal injury. Adv Exp Med Biol 1990;264:543-9.
14. Clements NC Jr, Habib MP. The early pattern of conjugated dienes in liver and lung after endotoxin exposure. Am J Respir Crit Care Med 1995;151:780-4.
15. Shibayanna Y. Role of lipid peroxidation in enhancement of endotoxin hepatotoxicity. Exp Toxicol Pathol 1992;44:205-8.
16. Demling RH, LaLonde C, Daryani R, Zhu DG, et al. Relationship between the lung and systemic response to endotoxin: comparison of physiologic change and the degree of lipid peroxidation. Circ Shock 1991;34:364-70.
17. Seekamp A, LaLonde C, Zhu DG, Demling RH. Catalase prevents prostanoid release and lung lipid peroxidation after endotoxemia in sheep. J Appl Physiol 1988;65:1210-6.
18. Nguyen TT, Cox CS, Traber DL, Grasser H. Free radical activity and loss of the plasma antioxidants vitamin E and sulfhydryl groups in patients with burns. J Burn Care Rehabil 1993;14:602-9.
19. Sugimo K, Dohi K, Yamada K, Kawasaki T. The role of lipid peroxidation in endotoxin-induced hepatic damage and the protective effect of antioxidants. Surgery 1987;101:746-52.
20. Washko P, Rotrosen D, Levine M. Ascorbic acid in human neutrophils. J Clin Nutr 1991;54:1221S-7S.
21. Tappel AL. Will antioxidant nutrients slow aging processes? Geriatrics 1968;23:97-105.
22. Jain A, Buist NR, Kennaway NG, Powell BR. Effect of ascorbate of N-acetylcysteine treatment in a patient with hereditary glutathione deficiency. J Pediatr 1994;124:229-33.
23. Meister A, Anderson ME. Glutathione. Annu Rev Biochem 1983;52:711-60.
24. Ogino T, Kawabata T, Awai M. Stimulation of glutathione synthesis in iron-loaded mice. Biochem Biophys Acta 1989; 1006:131-5.
25. Cotgreave I, Moldeua P, Schuppe I. The metabolism of N-acetylcysteine by human endothelial cells. Biochem Pharmacol 1991;41:13-6.
26. Walker HL, Mason AD, Gilbert LC, et al. Surface infection with pseudomonas aerugeinosa. Ann Surg 1964;160:297-305.
27. Sastre J, Asensi M, Gusco E, Pallardo FV, et al. Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration. Am J Physiol 1992;263:R922-R995.
28. Stocchi V, Cucchiarini L, Canestrari F, et al. Very fast iron-pair reverse phase HPLC method for the separation of the most significant nucleotides and their degradation products in human red blood cells. Anal Biochem 1987;167:181-90.
29. Atkinson DE. The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 1968;7:4030-4.
30. Aebi H. Catalase in vitro. Methods Enzymol 1984;105: 121-6.
31. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med 1963;61: 882-8.
32. Wagner ES, Lindley B, Coffin RD. High-performance liquid Chromatographic determination of ascorbic acid in urine. J Chromatography 1979;163:225-9.
33. McMurray CH, Blanchflower WJ. Application of a high-performance liquid Chromatographic fluorescence method for the rapid determination of alpha-tocopherol in the plasma of cattle and pigs and its comparison with direct fluorescence and high-performance liquid chromatography-ultraviolet detection methods. J Chromatography 1979;178:525-31.
34. Zhang H, Spapen H, Nguyen DH, Benlabed M, et al. Protective effects of N-acetyl-L-cysteine in endotoxemia. Am J Physiol 1994;226:H1746-H1754.
35. Abello PA, Fidler SA, Buckley GB, Buchman TG. Antioxidants modulate induction of programmed endothelial cell death (apoptosis) by endotoxin. Arch Surg 1994;129:134-40.
36. Hirasawa H, Chaudry IH, Baue AE. Beneficial effect of ATP-MgCl2-glucose administration on survival following sepsis. Surg Forum 1978;29:11-4.
37. LaLonde C, Nayak U, Hennigan J, Demling RH. Antioxidants prevent the cellular energy deficit produced in response to burn injury. J Burn Care Rehabil 1996;17:379-83.
38. Xuemin W, Kemling C, Ying S, Hanping S. Functional changes of the HADH respiratory chain in rat-liver mitochondria and the content changes in high energy phosphate groups in rat liver and heart during the early phase of burn injury. Burns 1990;16:377-80.
39. Kremer B, Allogower M, Graf M, Schmidt KH, et al. The present status of research in burn toxins. Intensive Care Med 1981;7:77-87.
40. Xia ZF, He F, Barrow RE, Broemeling LD, et al. Reperfusion injury in burned rats after delayed fluid resuscitation. J Burn Care Rehabil 1991;12:430-6.
41. Zaki MS, Burke JF, Trelstad RL. Protective effects of adenosine triphosphate administration in burns. Arch Surg 1978; 113:605-10.
42. Wooloscroft JO, Prasad JK, Thomson P, Till GO, et al. Metabolic alterations in burn patients: detection of adenine triphosphate degradation products and lipid peroxides. Burns 1990;16:92-6.
43. McGarrity ST, Stephenson AH, Webster RO. Regulation of human neutrophil functions by adenine nucleotides. J Immunology 1994;142:1986-94.
44. Jab CM, Neglen P, Eklof B. Breakdown of adenine nucleotides, formation of oxygen radicals, and early markers of cellular energy in endotoxic shock. Eur J Surg 1995;161:147-55.
45. Proctor RA, Denlinger LC, Leventhal PS, et al. Protection of mice from endotoxic death by 2-methylthio-ATP. Proc Natl Acad Sci U S A 1994;91:6017-20.
46. Rounds S, Hsieh L, Agarwal KC. Effects of endotoxin injury on endothelial cell adenosine metabolism. J Lab Clin Med 1994;123:309-17.
47. Hiraoka E, Nomami T, Kurokawa T, et al. The role of the spleen in endotoxin-induced liver injury. Liver 1995;15:35-8.
48. Liu P, Vonderfecht SL, Fisher MA. Priming of phagocytes for reactive oxygen production during hepatic ischemia-reperfusion. Circ Shock 1994;43:9-17.