Conditioning following repeated exposure to MDMA in rats: Role in the maintenance of MDMA self-administration

Behavioral Neuroscience

Volumn 120, Issue 5, 2006, Pages 1144-1150

  Daniela, Evangeline ^a   Gittings, David ^a   Schenk, Susan ^a  

^a VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

Author keywords

Conditioned effects; MDMA; Methylenedioxymethamphetamine; Rats; Self administration

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE;

ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG INFUSION; DRUG RESPONSE; DRUG SELF ADMINISTRATION; ILLUMINATION; INSTRUMENTAL CONDITIONING; MALE; NONHUMAN; PHOTOSTIMULATION; RAT; RAT STRAIN; REINFORCEMENT; RISK FACTOR; STIMULUS RESPONSE;

AMPHETAMINE-RELATED DISORDERS; ANIMALS; ASSOCIATION LEARNING; CONDITIONING, OPERANT; CUES; HALLUCINOGENS; INJECTIONS, INTRAVENOUS; MALE; MOTIVATION; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; PHOTIC STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; SELF ADMINISTRATION;

EID: 33750079270     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.120.5.1144     Document Type: Article

References (73)

1. Anggadiredja, K., Sakimura, K., Hiranita, T., & Yamamoto, T. (2004). Naltrexone attenuates cue- but not drug-induced methamphetamine seeking: A possible mechanism for the dissociation of primary and secondary reward. Brain Research, 1021, 272-276.
2. Beardsley, P. M., Balster, R. L., & Harris, L. S. (1986). Self-administration of methylenedioxymethamphetamine (MDMA) by rhesus monkeys. Drug Alcohol Dependence, 18, 149-157.
3. Berger, S. P., Hall, S., Mickalian, J. D., Reid, M. S., Crawford, C. A., Delucchi, K., et al. (1996). Haloperidol antagonism of cue-elicited cocaine craving. Lancet, 347, 504-508.
4. Bilsky, E. J., Hubbel, C. L., Delconte, J. D., & Reid, L. D. (1991). MDMA produces conditioned place preference and elicits ejaculation in male rats: A modulatory role for the endogenous opioids. Pharmacology, Biochemistry and Behavior, 40, 443-447.
5. Bilsky, E. J., & Reid, L. D. (1991). MDL72222, a serotonin 5-HT3 receptor antagonist, blocks MDMA's ability to establish a conditioned place preference. Pharmacology, Biochemistry and Behavior, 39, 509-512.
6. Cami, J., Farre, M., Mas, M., Roset, P. N., Poudevida, S., Mas, A., et al. (2000). Human pharmacology of 3,4-methylenedioxymethamphetamine ("ecstasy"): psychomotor performance and subjective effects. Journal of Clinical Psychopharmacology, 20, 455-466.
7. Chaudhri, N., Caggiula, A. R., Donny, E. C., Booth, S., Gharib, M. A., Craven, L. A., et al. (2005). Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in rats. Psychopharmacology, 180, 258-266.
8. Childress, A. R., Hole, A. V., Ehrman, R. N., Robbins, S. J., McLellan, A. T., & O'Brien, C. P. (1993). Cue reactivity and cue reactivity interventions in drug dependence. Nida Research Monograph, 137, 73-79.
9. Cohen, R. S. (1995). Subjective reports on the effects of the MDMA ("ecstasy") experience in humans. Progress in Neuropsychopharmacology and Biological Psychiatry, 19, 1137-1145.
10. Cottler, L. B., Womack, S. B., Compton, W. M., & Ben-Abdallah, A. (2001). Ecstasy abuse and dependence among adolescents and young adults: Applicability and reliability of DSM-IV criteria. Human Psychopharmacology, 16, 599-606.
11. Daniela, E., Brennan, K., Gittings, D., Hely, L., & Schenk, S. (2004). Effect of SCH 23390 on (±)-3,4-methylenedioxymethamphetamine hyperactivity and self-administration in rats. Pharmacology, Biochemistry and Behavior, 77, 745-750.
12. Davis, W. M., & Smith, S. G. (1976). Role of conditioned reinforcers in the initiation, maintenance and extinction of drug-seeking behavior. Pavlovian Journal of Biological Science, 11, 222-236.
13. De La Garza, R., II, Fabrizio, K. R., & Gupta, A. (2006). Relevance of rodent models of intravenous MDMA self-administration to human MDMA consumption patterns. Psychopharmacology, 10, 1-10.
14. Deroche-Gamonet, V., Martinez, A., Le Moal, M., & Piazza, P. V. (2003). Relationships between individual sensitivity to CS- and cocaine-induced reinstatement in the rat. Psychopharmacology, 168, 201-207.
15. Deroche-Gamonet, V., Piat, F., Le Moal, M., & Piazza, P. V. (2002). Influence of cue-conditioning on acquisition, maintenance and relapse of cocaine intravenous self-administration. European Journal of Neuroscience, 15, 1363-1370.
16. DiCiano, P., & Everitt, B. J. (2004). Contribution of the ventral tegmental area to cocaine seeking maintained by a drug-paired conditioned stimulus in rats. European Journal of Neuroscience, 19, 1661-1667.
17. Downing, J. (1986). The psychological and physiological effects of MDMA on normal volunteers. Journal of Psychoactive Drugs, 18, 335-340.
18. Ehrman, R. N., Robbins, S. J., Childress, A. R., & O'Brien, C. P. (1992). Conditioned responses to cocaine-related stimuli in cocaine abuse patients. Psychopharmacology, 107, 523-529.
19. Everitt, B. J., & Robbins, T. W. (2000). Second-order schedules of drug reinforcement in rats and monkeys: Measurement of reinforcing efficacy and drug-seeking behaviour. Psychopharmacology, 153, 17-30.
20. Fantegrossi, W. E., Ullrich, T., Rice, K. C., Woods, J. H., & Winger, G. (2002). 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: Serotonergic involvement. Psychopharmacology, 161, 356-364.
21. Fone, K. C., Beckett, S. R., Topham, I. A., Swettenham, J., Ball, M., & Maddocks, L. (2002). Long-term changes in social interaction and reward following repeated MDMA administration to adolescent rats without accompanying serotonergic neurotoxicity. Psychopharmacology, 159, 437-444.
22. Franken, I. H., Hendriks, V. M., Stam, C. J., & Van den Brink, W. (2004). A role for dopamine in the processing of drug cues in heroin dependent patients. European Neuropsychopharmacology, 14, 503-508.
23. Garavan, H., Pankiewicz, J., Bloom, A., Cho, J. K., Sperry, L., Ross, T. J., et al. (2000). Cue-induced cocaine craving: Neuroanatomical specificity for drug users and drug stimuli. American Journal of Psychiatry, 157, 1789-1798.
24. Gold, L. H., & Koob, G. F. (1989). MDMA produces stimulant-like conditioned locomotor activity. Psychopharmacology, 99, 352-356.
25. Goldberg, S. R., Kelleher, R. T., & Morse, W. H. (1975). Second-order schedules of drug injection. Federation Proceedings, 34, 1771-1776.
26. Gouzoulis-Mayfrank, E., Fischermann, T., Rezk, M., Thimm, B., Hensen, G., & Daumann, J. (2005). Memory performance in polyvalent MDMA (ecstasy) users who continue or discontinue MDMA use. Drug and Alcohol Dependence, 78, 317-323.
27. Grimm, J., Kruzich, P., & See, R. (2000). Contingent access to stimuli associated with cocaine self-administration is required for reinstatement of drug seeking behavior. Psychobiology, 28, 383-386.
28. Grob, C. S., Poland, R. E., Chang, L., & Ernst, T. (1996). Psychobiologic effects of 3,4-methylenedioxymethamphetamine in humans: Methodological considerations and preliminary observations. Behavioural Brain Research, 73, 103-107.
29. Harris, D. S., Baggott, M., Mendelson, J. H., Mendelson, J. E., & Jones, R. T. (2002). Subjective and hormonal effects of 3,4- methylenedioxymethamphetamine (MDMA) in humans. Psychopharmacology, 162, 396-405.
30. Harris, D. S., Batki, S. L., & Berger, S. P. (2004). Fluoxetine attenuates adrenocortical but not subjective responses to cocaine cues. American Journal of Drug and Alcohol Abuse, 30, 765-782.
31. Hartz, D. T., Frederick-Osborne, S. L., & Galloway, G. P. (2001). Craving predicts use during treatment for methamphetamine dependence: A prospective, repeated-measures, within-subject analysis. Drug and Alcohol Dependence, 63, 269-276.
32. Horan, B., Gardner, E. L., & Ashby, C. R., Jr. (2000). Enhancement of conditioned place preference response to cocaine in rats following subchronic administration of 3, 4-methylenedioxymethamphetamine (MDMA). Synapse, 35, 160-162.
33. Horwitz, R. I., Gottlieb, L. D., & Kraus, M. L. (1989). The efficacy of atenolol in the outpatient management of the alcohol withdrawal syndrome. Results of a randomized clinical trial. Archives of Internal Medicine, 149, 1089-1093.
34. Jansen, K. L. (1999). Ecstasy (MDMA) dependence. Drug and Alcohol Dependence, 53, 121-124.
35. Killen, J. D., & Fortmann, S. P. (1997). Craving is associated with smoking relapse: Findings from three prospective studies. Experimental and Clinical Psychopharmacology, 5, 137-142.
36. Lamb, R. J., & Griffiths, R. R. (1987). Self-injection of 3,4-methylenedioxymethamphetamine (MDMA) in the baboon. Psychopharmacology, 91, 268-272.
37. Lamb, R. J., Preston, K. L., Schindler, C. W., Meisch, R. A., Davis, F., Katz, J. L., et al. (1991). The reinforcing and subjective effects of morphine in post-addicts: A dose-response study. Journal of Pharmacology and Experimental Therapeutics, 259, 1165-1173.
38. Leshner, A. I. (1998). Where do we go from here and how do we get there? Annals of the New York Academy of Sciences, 846, 348-354.
39. Lester, S. J., Baggott, M., Welm, S., Schiller, N. B., Jones, R. T., Foster, E., & Mendelson, J. (2000). Cardiovascular effects of 3,4-methylenedioxymethamphetamine. A double-blind, placebo-controlled trial. Annals of Internal Medicine, 133, 969-973.
40. Lile, J. A., Ross, J. T., & Nader, M. A. (2005). A comparison of the reinforcing efficacy of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") with cocaine in rhesus monkeys. Drug and Alcohol Dependence, 78, 135-140.
41. Mas, M., Farre, M., de la Torre, R., Roset, P. N., Ortuno, J., Segura, J., & Cami, J. (1999). Cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-methylenedioxymethamphetamine in humans. Journal of Pharmacology and Experimental Therapeutics, 290, 136-145.
42. McCann, U. D., Szabo, Z., Seckin, E., Rosenblatt, P., Mathews, W. B., Ravert, H. T., et al. (2005). Quantitative PET studies of the serotonin transporter in MDMA users and controls using [(11)C]McN5652 and [(11)C]DASB. Neuropsychopharmacology, 2005, 30, 1741-1750.
43. McDowell, D. M., & Kleber, H. D. (1994). MDMA: Its history and pharmacology. Psychiatric Annals, 24, 127-130.
44. Meilman, P. W., Gaylor, M. S., Turco, J. H., & Stone, J. E. (1990). Drug use among college undergraduates: Current use and 10-year trends. International Journal of the Addictions, 25, 1025-1036.
45. Mello, N. K., Mendelson, J. H., Kuehnle, J. C., & Sellers, M. S. (1981). Operant analysis of human heroin self-administration and the effects of naltrexone. Journal of Pharmacology and Experimental Therapeutics, 216, 45-54.
46. Meyer, A., Mayerhofer, A., Kovar, K. A., & Schmidt, W. J. (2002). Rewarding effects of the optical isomers of 3,4-methylenedioxymethamphetamine ("Ecstasy") and 3,4-methylenedioxyethylamphetamine ("Eve") measured by conditioned place preference in rats. Neuroscience Letters, 330, 280-284.
47. Neisewander, J. L., O'Dell, L. E., Tran-Nguyen, L. T., Castaneda, E., & Fuchs, R. A. (1996). Dopamine overflow in the nucleus accumbens during extinction and reinstatement of cocaine self-administration behavior. Neuropsychopharmacology, 15, 506-514.
48. O'Brien, C., Childress, A. R., Ehrman, R., Robbins, S., & McLellan, A. T. (1992). Conditioning mechanisms in drug dependence. Clinical Neuropharmacology, 15(Suppl 1A), 66A-67A.
49. Palmatier, M. I., Evans-Martin, F. F., Hoffman, A., Caggiula, A. R., Chaudhri, N., Donny, E. C., et al. (2006). Dissociating the primary reinforcing and reinforcement enhancing effects of nicotine using a rat self-administration paradigm with concurrently available drug and environmental reinforcers. Psychopharmacology, 184, 391-400.
50. Panlilio, L. V., Weiss, S. J., & Schindler, C. W. (1996). Cocaine self-administration increased by compounding discriminative stimuli. Psychopharmacology, 125, 202-208.
51. Panlilio, L. V., Weiss, S. J., & Schindler, C. W. (2000). Effects of compounding drug-related stimuli: Escalation of heroin self-administration. Journal of the Experimental Analysis of Behavior, 73, 211-224.
52. Panlilio, L. V., Yasar, S., Nemeth-Coslett, R., Katz, J. L., Henningfield, J. E., Solinas, M., et al. (2005). Human cocaine-seeking behaviour and its control by drug-associated stimuli in the laboratory. Neuropsychopharmacology, 30, 433-443.
53. Parrott, A. C. (2005). Chronic tolerance to recreational MDMA (3,4-methylenedioxymethamphetamine) or ecstasy. Journal of Psychopharmacology, 19, 71-83.
54. Ratzenboeck, E., Saria, A., Kriechbaum, N., & Zernig, G. (2001). Reinforcing effects of MDMA ("ecstasy") in drug-naïve and cocaine-trained rats. Pharmacology, 62, 138-144.
55. Robinson, T. E., & Berridge, K. C. (1993). The neural basis of drug craving: An incentive-sensitization theory of addiction. Brain Research Reviews, 18, 247-291.
56. Schecter, M. D. (1991). Effect of MDMA neurotoxicity upon its conditioned place preference and discrimination. Pharmacology, Biochemistry and Behavior, 38, 539-544.
57. Schenk, S., Gittings, D., Johnstone, M., & Daniela, E. (2003). Development, maintenance and temporal pattern of self-administration maintained by ecstasy (MDMA) in rats. Psychopharmacology, 169, 21-27.
58. Schenk, S., & Partridge, B. (2001). Influence of a conditioned light stimulus on cocaine self-administration in rats. Psychopharmacology, 154, 390-396.
59. See, R. E., Grimm, J. W., Kruzich, P. J., & Rustay, N. (1999). The importance of a compound stimulus in conditioned drug-seeking behavior following one week of extinction from self-administered cocaine in rats. Drug and Alcohol Dependence, 57, 41-49.
60. Shulman, G. D. (1989). Experience with the cocaine trigger inventory. Advances in Alcohol and Substance Abuse, 8, 71-85.
61. Smith, S. G., Werner, T. E., & Davis, W. M. (1977). Alcohol-associated conditioned reinforcement. Psychopharmacology, 53, 223-226.
62. Solowij, N., Hall, W., & Lee, N. (1992). Recreational MDMA use in Sydney: A profile of "ecstasy" users and their experiences with the drug. British Journal of Addiction, 87, 1161-1172.
63. Tancer, M., & Johanson, C. E. (2003). Reinforcing, subjective and physiological effects of MDMA in humans: A comparison with d-amphetamine and mCPP. Drug Alcohol Dependence, 72, 33-44.
64. Topp, L., Hando, J., Dillon, P., Roche, A., & Solowij, N. (1999). Ecstasy use in Australia: Patterns of use and associated harm. Drug and Alcohol Dependence, 55, 105-115.
65. Tran-Nguyen, L., Fuchs, R., Coffey, G., Baker, D., O'Dell, L., & Neiswander, J. (1998). Time dependent changes in cocaine seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. Neuropsychopharmacology, 19, 48-59.
66. Verheyden, S. L., Henry, J. A., & Curran, H. V. (2003). Acute, sub-acute and long-term subjective consequences of "ecstasy" (MDMA) consumption in 430 regular users. Human Psychopharmacology, 18, 507-517.
67. Vollenweider, E. X., Gamma, A., Liechti, M., & Huber, T. (1998). Psychological and cardiovascular effects and short-term sequelae of MDMA ("ecstasy") in MDMA-naive healthy volunteers. Neuropsychopharmacology, 19, 241-251.
68. Von Sydow, K., Lieb, R., Pfister, H., Hofler, M., & Wittchen, H. U. (2002). Use, abuse and dependence of ecstasy and related drugs in adolescents and young adults-A transient phenomenon? Results from a longitudinal community study. Drug and Alcohol Dependence, 66, 147-159.
69. Wallace, B. C. (1989). Psychological and environmental determinants of relapse in crack cocaine smokers. Journal of Substance Abuse Treat, 6, 95-106.
70. Waters, A. J., Shiffman, S., Sayette, M. A., Paty, J. A., Gwaltney, C. J., & Balabanis, M. H. (2004). Cue-provoked craving and nicotine replacement therapy in smoking cessation. Journal of Consulting and Clinical Psychology, 72, 1136-1143.
71. Weiss, F., Martin-Fardon, R., Ciccocioppo, R., Kerr, T. M., Smith, D. L., & Ben-Shahar, O. (2001). Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues. Neuropsychopharmacology, 25, 361-372.
72. Weiss, S. J., Kearns, D. N., & Cohn, S. I. (2003). Stimulus control of cocaine self-administration. Journal of the Experimental Analysis of Behavior, 79, 111-135.
73. Wikler, A. (1973). Dynamics of drug dependence. Implications of a conditioning theory for research and treatment. Archives of General Psychiatry, 28, 611-616.