Combining FCU/5-FU suicide gene/prodrug system and radiation in treating nasopharyngeal carcinoma: An experimental study

Chinese Journal of Pathology

Volumn 35, Issue 8, 2006, Pages 483-487

  Tang, Yao Yun ^a   Zhao, Su Ping ^a   Xu, Jing ^a   Zhong, Yu ^a   Xiao, Jian Yun ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Drug therapy, combination; Gene, suppressor, tumor; Nasopharyngeal neoplasms; Radiotherapy

Indexed keywords

FLUCYTOSINE; PROTEIN; PROTEIN FCU; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL KILLING; CONTROLLED STUDY; ELECTROPORATION; GAMMA IRRADIATION; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; PROTEIN EXPRESSION; SUICIDE GENE; SURVIVAL RATE; TUMOR GROWTH; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; FLUOROURACIL; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; HUMANS; MICE; MICE, NUDE; NASOPHARYNGEAL NEOPLASMS; PRODRUGS; RADIOTHERAPY; TIME FACTORS; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 33750061357     PISSN: 05295807     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Cohen SJ, Dobelbower R Jr, Lipsitz S, et al. A randomized phase III study of radiotherapy alone or with 5-fluorouracil and mitomycin-C in patients with locally advanced adenocarcinoma of the pancreas: Eastern Cooperative Oncology Group study E8282. Int J Radiat Oncol Biol Phys, 2005, 62:1345-1350.
2. Chung-Faye GA, Chen MJ, Green NK, et al. In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase. Gene Ther, 2001, 8:1547-1554.
3. Koyama F, Sawada H, Hirao T, et al. Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine. Cancer Gene Ther, 2000, 7:1015-1022.
4. Benouchan M, Do Nascimento F, Sebbah-Louriki M, et al. Bystander cell killing spreading from endothelial to tumor cells in a three-dimensional multicellular nodule model after Escherichia coli nitroreductase gene delivery. Biochem Biophys Res Commun, 2003, 311:822-828.
5. Matono S, Tanaka T, Sueyoshi S, et al. Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer. Int J Oncol, 2003, 23:1309-1315.
6. Asklund T, Appelskog IB, Ammerpohl O, et al. Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene. Exp Cell Res, 2003, 284:185-195.
7. Bharara S, Sorscher EJ, Gillespie GY, et al. Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy. Hum Gene Ther, 2005, 16:339-347.
8. Greco O, Marples B, Dachs GU, et al. Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. Gene Ther, 2002, 9:1403-1411.
9. Xia K, Liang D, Tang A, et al. A novel fusion suicide gene yeast CDglyTK plays a role in radio-gene therapy of nasopharyngeal carcinoma. Cancer Gene Ther, 2004, 11:790-796.
10. Satoh T, Irie A, Egawa S, et al. In situ gene therapy for prostate cancer. Curr Gene Ther, 2005, 5:111-119.
11. Cristiano RJ. Protein/DNA polyplexes for gene therapy. Surg Oncol Clin N Am, 2002, 11:697-716.
12. Rainov NG, Kramm CM. Vector delivery methods and targeting strategies for gene therapy of brain tumors. Curr Gene Ther, 2001, 1: 367-383.