Remission of collagen-induced arthritis is associated with high levels of transforming growth factor-β expression in the joint

Clinical and Experimental Immunology

Volumn 146, Issue 2, 2006, Pages 287-293

  Marinova Mutafchieva, L ^a   Gabay, C ^b   Funa, K ^c   Williams, R O ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Animal models; Collagen induced arthritis; Cytokines; Rheumatoid arthritis; Transforming growth factor beta

Indexed keywords

COLLAGEN TYPE 2; CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE COURSE; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; INFLAMMATORY DISEASE; JOINT; MALE; NONHUMAN; PRIORITY JOURNAL; REMISSION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; COLLAGEN TYPE II; CYTOKINES; INFLAMMATION MEDIATORS; JOINTS; MALE; MICE; MICE, INBRED DBA; REMISSION, SPONTANEOUS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33750061010     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2006.03204.x     Document Type: Article

References (19)

1. Williams RO. Rodent models of arthritis: relevance for human disease. Clin Exp Immunol 1998; 114:330-2.
2. Holmdahl R, Andersson ME, Goldschmidt TJ et al. Collagen induced arthritis as an experimental model for rheumatoid arthritis. Immunogenetics, pathogenesis and autoimmunity. APMIS 1989; 97:575-84.
3. Trentham DE. Collagen arthritis as a relevant model for rheumatoid arthritis: evidence pro and con. Arthritis Rheumatism 1982; 25:911-6.
4. Marinova-Mutafchieva L, Williams RO, Mason LJ, Mauri C, Feldmann M, Maini RN. Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA). Clin Exp Immunol 1997; 107:507-12.
5. Gabay C, Marinova-Mutafchieva L, Williams RO et al. Increased production of intracellular interleukin-1 receptor antagonist (icIL-1Ra1) in the synovium in collagen-induced arthritis: a possible role in the resolution of arthritis. Arthritis Rheum 2001; 44:451-62.
6. Marinova-Mutafchieva L, Williams RO, Funa K, Maini RN, Zvaifler NJ. Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis. Arthritis Rheum 2002; 46:507-13.
7. Thornton S, Duwel LE, Boivin GP, Ma Y, Hirsch R. Association of the course of collagen-induced arthritis with distinct patterns of cytokine and chemokine messenger RNA expression. Arthritis Rheum 1999; 42:1109-18.
8. Mussener A, Funa K, Kleinau S, Klareskog L. Dynamic expression of transforming growth factor-betas (TGF-beta) and their type I and type II receptors in the synovial tissue of arthritic rats. Clin Exp Immunol 1997; 107:112-9.
9. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006; 24:179-89.
10. Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235-8.
11. Mangan PR, Harrington LE, O'Quinn DB et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441:231-4.
12. Sime PJ, Marr RA, Gauldie D et al. Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. Am J Pathol 1998; 153:825-32.
13. Marino MW, Dunn A, Grail D et al. Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 1997; 94:8093-8.
14. Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 1996; 14:397-440.
15. Thorbecke GJ, Shah R, Leu CH, Kuruvilla AP, Hardison AM, Palladino MA. Involvement of endogenous tumor necrosis factor α and transforming growth factor β during induction of collagen type II arthritis in mice. Proc Natl Acad Sci USA 1992; 89:7375-9.
16. Santambrogio L, Hochwald GM, Leu CH, Thorbecke GJ. Antagonistic effects of endogenous and exogenous TGF-beta and TNF on auto-immune diseases in mice. Immunopharmacol Immunotoxicol 1993; 15:461-78.
17. Prud'homme GJ, Piccirillo CA. The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases. J Autoimmun 2000; 14:23-42.
18. Peng Y, Laouar Y, Li MO, Green EA, Flavell RA. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci USA 2004; 101:4572-7.
19. Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR, Neurath MF. Cutting edge. TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 2004; 172:5149-53.