Essential fatty acid uptake and metabolism in the developing rodent brain

Lipids

Volumn 31, Issue 3 SUPPL., 1996, Pages

  Pawlosky, Robert J ^a   Ward, Glenn ^a   Salem Jr , Norman ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; RODENTIA;

DOCOSAHEXAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BRAIN; CEREBELLUM; CONFERENCE PAPER; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; FATTY ACID TRANSPORT; FEMALE; GAS CHROMATOGRAPHY; LIVER; MASS SPECTROMETRY; MOUSE; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; RAT;

ADMINISTRATION, ORAL; ALPHA-LINOLENIC ACID; ANIMALS; ANIMALS, SUCKLING; BRAIN; DEUTERIUM; FATTY ACIDS, ESSENTIAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LINOLEIC ACID; LINOLEIC ACIDS; LIVER; MICE; RATS;

EID: 0029866221     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02637060     Document Type: Article

References (19)

1. Altman, J. (1972) Postnatal Development of Cerebellar Cortex in the Rat J. Comp. Neur. 145, 399-464.
2. Innis, S.M. (1991) Essential Fatty Acids in Growth and Development, Prog. Lipid Res. 30, 39-103.
3. Sinclair, A.J. (1974) Incorporation of Radioactive Polyunsaturated Fatty Acids into Liver and Brain of Developing Rat, Lipids 10, 175-184.
4. 14C Linolenic Acid into Brain Fatty Acids, Lipids 10, 238-241.
5. Dhopeshwarkar, G.A., and Subramanian, C. (1976) Intracranial Conversion of Linoleic Acid to Arachidonic Acid: Evidence for Lack of 8-Desaturase in the Brain, J. Neurochem. 26, 1175-1179.
6. Cook, H.W. (1978) In Vitro Formation of Polyunsaturated Fatty Acids by Desaturation in Rat Brain: Some Properties of Enzymes in Developing Brain and Comparisons with Liver, J. Neurochem. 30, 1327-1334.
7. 14C] Linolenate into Lipids of Developing Rat Brain During Essential Fatty Acid Deprivation, J. Neurochem. 32, 833-838.
8. 14C] Linolenate in Developing Rat Brain, Biochim. Biophys. Acta 575, 309-317.
9. Naughton, J.M. (1980) The Ease of Conversion of the Short-Chain Essential Fatty Acids to Their Longer Chain Polyunsaturated Metabolites in Liver, Brain, Placenta and Blood, Int. J. Biochem. 13, 21-32.
10. Purvis, J.M., Clandinin, M.T., and Hacker, R.R. (1983) Chain Elongation-Desaturation of Linoleic Acid During the Development of the Pig: Implications for the Supply of Polyenoic Fatty Acids to the Developing Brain, Camp. Biochem. Physiol. 75B, 199-204.
11. Clandinin, M.T., Wong, K., and Hacker, R.R. (1985) Synthesis of Chain Elongation-Desaturation Products of Linoleic Acid by Liver and Brain Microsomes During Development of the Pig, Biochem. J. 226, 305-309.
12. Green, P., and Yavin, E. (1993) Elongation, Desaturation, and Esterification of Essential Fatty Acids by Fetal Rat Brain In Vivo, J. Lipid Res. 34, 2099-2107.
13. Pawlosky, R.J., Barnes, A., and Salem, N., Jr. (1994) Essential Fatty Acid Metabolism in the Feline: The Relationship Between Liver and Brain Production of Long-Chain Polyunsaturated Fatty Acids, J. Lipid Res. 35, 2032-2039.
14. Scott, B.L., and Bazan, N.G. (1989) Membrane Docosahexaenoate Is Supplied to the Developing Brain and Retina by the Liver, Proc. Natl. Acad. Sci. USA 86, 2903-2907.
15. Schoenheimer, R., and Rittenberg D. (1935) Deuterium as an Indicator in the Study of Intermediary Metabolism, J. Biol. Chem. 111, 175-180.
16. Pawlosky, R.J., Sprecher, H., and Salem N., Jr. (1992) A High Sensitivity Negative Ion GC-MS Method for the Detection of Desaturated and Chain Elongated Products of Deuterated Linoleic and Linolenic Acid, J. Lipid Res. 33, 1711-1718.
17. Bligh, E.G., and Dyer, W.J. (1959) A Rapid Method of Total Lipid Extraction and Purification, Can. J. Biochem. Physiol. 37, 911-916.
18. Hrboticky, N., Mackinnon, M.J., and Innis, S.M. (1990) Effect of a Vegetable Oil Formula Rich in Linoleic Acid on Tissue Fatty Acid Accretion in the Brain, Liver, Plasma, and Erythrocytes of Infant Piglets, Am. J. Clin. Nutr. 51, 173-182.
19. Hrboticky, N., Mackinnon, M.J., and Innis, S.M. (1991) Retina Fatty Acyl Composition of Piglets Fed from Birth with a 18:2n-6 Rich Vegetable-Oil Formula for Infants, Am. J. Clin. Nutr. 53, 483-490.