Apolipoprotein E ε4 allele is associated with the volume of white matter changes in patients with lacunar infarcts

European Journal of Neurology

Volumn 13, Issue 11, 2006, Pages 1216-1220

  Wen, H M ^a,b   Baum, L ^b   Cheung, W S ^b   Mok, V ^b   Lam, W W M ^b   Tomlinson, B ^b   Wong, K S ^b   Ng, H K ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apolipoprotein E; Binswanger's disease; Genotype; Ischemic; Leukoaraiosis; Polymorphism; Stroke

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; APOLIPOPROTEIN E;

AGED; ALLELISM; ALZHEIMER DISEASE; ARTICLE; BRAIN INFARCTION; BRAIN SIZE; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; EXON; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; WHITE MATTER; ALLELE; BRAIN; CASE CONTROL STUDY; COMPARATIVE STUDY; GENE FREQUENCY; GENETICS; HOSPITALIZATION; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY;

AGED; AGED, 80 AND OVER; ALLELES; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BRAIN; BRAIN INFARCTION; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 33750039967     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2006.01436.x     Document Type: Article

References (37)

1. Miyao S, Takano A, Teramoto J, Takahashi A. Leukoaraiosis in relation to prognosis for patients with lacunar infarction. Stroke 1992; 23: 1434-1438.
2. Breteler MM, van Amerongen NM, van Swieten JC, et al. Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study. Stroke 1994; 25: 1109-1115.
3. Gunning-Dixon FM, Raz N. The cognitive correlates of white matter abnormalities in normal aging: a quantitative review. Neuropsychology 2000; 14: 224-232.
4. Longstreth WT Jr, Manolio TA, Arnold A, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke 1996; 27: 1274-1282.
5. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988; 240: 622-630.
6. Siest G, Pillot T, Regis-Bailly A, et al. Apolipoprotein E: an important gene and protein to follow in laboratory medicine. Clinical Chemistry 1995; 41: 1068-1086.
7. Mahley RW, Rall SC Jr. Apolipoprotein E: far more than a lipid transport protein. Annual Review of Genomics and Human Genetics 2000; 1: 507-537.
8. Bronge L. Magnetic resonance imaging in dementia. A study of brain white matter changes. Acta Radiologica 2002; 43 (Suppl 428): 1-32.
9. Schmidt H, Schmidt R, Fazekas F, et al. Apolipoprotein E e4 allele in the normal elderly: neuropsychologic and brain MRI correlates. Clinical Genetics 1996; 50: 293-299.
10. Kuller LH, Shemanski L, Manolio T, et al. Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study. Stroke 1998; 29: 388-398.
11. Barber R, Gholkar A, Scheltens P, et al. Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias. Archives of Neurology 1999; 56: 961-965.
12. Doody RS, Azher SN, Haykal HA, Dunn JK, Liao T, Schneider L. Does APO epsilon4 correlate with MRI changes in Alzheimer's disease? Journal of Neurology, Neurosurgery and Psychiatry 2000; 69: 668-671.
13. Szolnoki Z, Somogyvari F, Kondacs A, et al. Specific APO E genotypes in combination with the ACE D/D or MTHFR 677TT mutation yield an independent genetic risk of leukoaraiosis. Acta Neurologica Scandinavica 2004; 109: 222-227.
14. WHO. Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997; 20: 1183-1197.
15. NCEP. Summary of the second report of the National Cholesterol Education Program. Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel II). Journal of the American Medical Association 1993; 269: 3015-3023.
16. Kontula K, alto-Setala K, Kuusi T, Hamalainen L, Syvanen AC. Apolipoprotein E polymorphism determined by restriction enzyme analysis of DNA amplified by polymerase chain reaction: convenient alternative to phenotyping by isoelectric focusing. Clinical Chemistry 1990; 36: 2087-2092.
17. Chen L, Baum L, Ng HK, Chan LY, Pang CP. Apolipoprotein E genotype and its pathological correlation in Chinese Alzheimer's disease with late onset. Human Pathology 1999; 30: 1172-1177.
18. Fein G, Di SV, Tanabe J, et al. Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease. Neurology 2000; 55: 1626-1635.
19. Schmidt R, Fazekas F, Offenbacher H, et al. Neuropsychologic correlates of MRI white matter hyperintensities: a study of 150 normal volunteers. Neurology 1993; 43: 2490-2494.
20. Hirono N, Kitagaki H, Kazui H, Hashimoto M, Mori E. Impact of white matter changes on clinical manifestation of Alzheimer's disease: a quantitative study. Stroke 2000a; 31: 2182-2188.
21. Wen HM, Mok VC, Fan YH, et al. Effect of white matter changes on cognitive impairment in patients with lacunar infarcts. Stroke 2004; 35: 1826-1830.
22. Fan YH, Lam WW, Mok VC, Huang RX, Wong KS. Variability and validity of a simple visual rating scale in grading white matter changes on magnetic resonance imaging. Journal of Neuroimaging 2003; 13: 255-258.
23. Kapeller P, Barber R, Vermeulen RJ, et al. Visual rating of age-related white matter changes on magnetic resonance imaging: scale comparison, interrater agreement, and correlations with quantitative measurements. Stroke 2003; 34: 441-445.
24. Kinkel WR, Jacobs L, Polachini I, Bates V, Heffner RR Jr. Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Computed tomographic, nuclear magnetic resonance, and clinical correlations. Archives of Neurology 1985; 42: 951-959.
25. Awad IA, Johnson PC, Spetzler RF, Hodak JA. Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Postmortem pathological correlations. Stroke 1986; 17: 1090-1097.
26. Kirkpatrick JB, Hayman LA. White-matter lesions in MR imaging of clinically healthy brains of elderly subjects: possible pathologic basis. Radiology 1987; 162: 509-511.
27. Fazekas F, Kleinert R, Offenbacher H, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 1993; 43: 1683-1689.
28. Hodis HN, Mack WJ. Triglyceride-rich lipoproteins and the progression of coronary artery disease. Current Opinion in Lipidology 1995; 6: 209-214.
29. McCarron MO, Delong D, Alberts MJ. APOE genotype as a risk factor for ischemic cerebrovascular disease: a meta-analysis. Neurology 1999; 53: 1308-1311.
30. Sawada H, Udaka F, Izumi Y, et al. Cerebral white matter lesions are not associated with apoE genotype but with age and female sex in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry 2000; 68: 653-656.
31. Hirono N, Yasuda M, Tanimukai S, Kitagaki H, Mori E. Effect of the apolipoprotein E epsilon4 allele on white matter hyperintensities in dementia. Stroke 2000; 31: 1263-1268.
32. Kokubo Y, Chowdhury AH, Date C, Yokoyama T, Sobue H, Tanaka H. Age-dependent association of apolipoprotein E genotypes with stroke subtypes in a Japanese rural population. Stroke 2000; 31: 1299-1306.
33. Catto AJ, McCormack LJ, Mansfield MW, et al. Apolipoprotein E polymorphism in cerebrovascular disease. Acta Neurologica Scandinavica 2000; 101: 399-404.
34. Amar K, MacGowan S, Wilcock G, Lewis T, Scott M. Are genetic factors important in the aetiology of leukoaraiosis? Results from a memory clinic population. International Journal of Geriatric Psychiatry 1998; 13: 585-590.
35. Utermann G. Alzheimer's disease. The apolipoprotein E connection. Current Biology 1994; 4: 362-365.
36. DeCarli C, Reed T, Miller BL, Wolf PA, Swan GE, Carmelli D. Impact of apolipoprotein E epsilon4 and vascular disease on brain morphology in men from the NHLBI twin study. Stroke 1999; 30: 1548-1553.
37. Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. Stroke 1995; 26: 1293-1301.