Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus

Brain Research

Volumn 1117, Issue 1, 2006, Pages 54-60

  Dolotov, Oleg V ^a   Karpenko, Ekaterina A ^a   Inozemtseva, Lyudmila S ^a   Seredenina, Tamara S ^a   Levitskaya, Natalia G ^a   Rozyczka, Joanna ^c   Dubynina, Elena V ^a   Novosadova, Ekaterina V ^a   Andreeva, Lyudmila A ^a   Alfeeva, Lyudmila Yu ^a   Kamensky, Andrey A ^b   Grivennikov, Igor A ^a   Myasoedov, Nikolay F ^a   Engele, Jürgen ^c  

^a INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

ACTH(4 10); BDNF; Cognitive effect; Hippocampus; trkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CORTICOTROPIN[4-10]; MESSENGER RNA; SEMAXANIB; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; BODY WEIGHT; BRAIN FUNCTION; BRAIN LEVEL; COGNITION; CONDITIONING; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EXON; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SINGLE DRUG DOSE; UPREGULATION;

ADMINISTRATION, INTRANASAL; ADRENOCORTICOTROPIC HORMONE; ANIMALS; AVOIDANCE LEARNING; BODY WEIGHT; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION; CONDITIONING (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; EXONS; HIPPOCAMPUS; NOOTROPIC AGENTS; PEPTIDE FRAGMENTS; RATS; REACTION TIME; RECEPTOR, TRKB; RNA, MESSENGER; UP-REGULATION;

ANIMALIA;

EID: 33749994334     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.07.108     Document Type: Article

References (27)

1. Adan R.A., Cone R.D., Burbach J.P., and Gispen W.H. Differential effects of melanocortin peptides on neural melanocortin receptors. Mol. Pharmacol. 46 (1994) 1182-1190
2. Ashmarin I.P., Nezavibat'ko V.N., Levitskaya N.G., Koshelev V.B., and Kamensky A.A. Design and investigation of ACTH(4-10) analog deprived of d-amino acids and hydrophobic radicals. Neurosci. Res. Commun. 16 (1995) 105-112
3. Berchtold N., Oliff H., Isackson P., and Cotman C. Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Mol. Brain Res. 71 (1999) 11-22
4. Bohus B., and Lissak K. Adrenocortical hormones and avoidance behavior of rats. J. Neuropharmacol. 7 (1968) 301-306
5. de Wied D. Oral pharmacology of neuropeptides related to melanocortins and the neurohypophyseal hormones. Eur. J. Pharmacol. 375 (1999) 1-11
6. Dolotov O.V., Karpenko E.A., Seredenina T.S., Inozemtseva L.S., Levitskaya N.G., Zolotarev A.Yu., Kamensky A.A., Grivennikov I.A., Engele J., and Myasoedov N.F. Semax, an analog of adrenocorticotropin (4-10), binds specifically and increases BDNF protein levels in the rat basal forebrain. J. Neurochem. 97 s1 (2006) 82-86
7. Duman R.S. Role of neurotrophic factors in the etiology and treatment of mood disorders. NeuroMolecular Med. 5 (2004) 11-25
8. Ferrer I., Ballabriga J., Marti E., Perez E., Alberch J., and Arenas E. BDNF up-regulates TrkB protein and prevents the death of CA1 neurons following transient forebrain ischemia. Brain Pathol. 8 (1998) 253-261
9. Figiel M., and Engele J. Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuron-derived peptide regulating glial glutamate transport and metabolism. J. Neurosci. 20 (2000) 3596-3605
10. Grivennikov I.A., Dolotov O.V., and Goldina Yu.I. Factors of peptidergic nature in the processes of proliferation, differentiation and survival of the cells from mammalian nervous system. Mol. Biol. (Mosk.) 33 (1999) 1-7
11. Hall J., Thomas K.L., and Everitt B.J. Rapid and selective induction of BDNF expression in the hippocampus during contextual learning. Nat. Neurosci. 3 (2000) 533-535
12. Hicks R.R., Martin V.B., Zhang L., and Seroogy K.B. Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Exp. Neurol. 160 (1999) 469-478
13. Kaplan A.Ya., Kochetova A.G., Nezavibat'ko V.N., Rjasina T.V., and Ashmarin I.P. Synthetic ACTH analogue Semax displays nootropic-like activity in humans. Neurosci. Res. Commun. 19 (1996) 115-123
14. Kokaia Z., Nawa H., Uchino H., Elmer E., Kokaia M., Carnahan J., Smith M.L., Siesjo B.K., and Lindvall O. Regional brain-derived neurotrophic factor mRNA and protein levels following transient forebrain ischemia in the rat. Mol. Brain Res. 38 (1996) 139-144
15. Lindqvist N., VidalSanz M., and Hallbook F. Single cell RT-PCR analysis of tyrosine kinase receptor expression in adult rat retinal ganglion cells isolated by retinal sandwiching. Brain Res. Protoc. 10 (2002) 75-83
16. Metsis M., Timmusk T., Arenas E., and Persson H. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proc. Natl. Acad. Sci. 90 (1993) 8802-8806
17. Mizuno M., Yamada K., Olariu A., Nawa H., and Nabeshima T. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. J. Neurosci. 20 (2000) 7116-7121
18. Mu J.S., Li W.P., Yao Z.B., and Zhou X.F. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats. Brain Res. 835 (1999) 259-265
19. Peterson G.L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83 (1977) 346-356
20. Pollock G.S., Vernon E., Forbes M.E., Yan Q., Ma Y.T., Hsieh T., Robichon R., Frost D.O., and Johnson J.E. Effects of early visual experience and diurnal rhythms on BDNF mRNA and protein levels in the visual system, hippocampus, and cerebellum. J. Neurosci. 21 (2001) 3923-3931
21. Potaman V.N., Alfeeva L.Y., Kamensky A.A., Levitskaya N.G., and Nezavibatko V.N. N-terminal degradation of ACTH(4-10) and its synthetic analog semax by the rat blood enzymes. Biochem. Biophys. Res. Commun. 176 (1991) 741-746
22. Shadrina M.I., Dolotov O.V., Grivennikov I.A., Inozemtseva L.S., Slominsky P.A., Limborska S.A., and Myasoedov N.F. Rapid and efficient NGF and BDNF mRNA induction in the rat glial cell cultures upon ACTH(4-10) analog "Semax" action. Neurosci. Lett. 308 (2001) 115-118
23. Smith M.A., Makino S., Kvetnansky R., and Post R.M. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNA in the hippocampus. J. Neurosci. 15 (1995) 1768-1777
24. Strand F.L., Zuccarelli L.A., Williams K.A., Lee S.J., Lee T.S., Antonawich F.J., and Alves S.E. Melanotropins as growth factors. Ann. N. Y. Acad. Sci. 680 (1993) 29-50
25. Tabuchi A., Sakaya H., Kisukeda T., Fushiki H., and Tsuda M. Involvement of an upstream stimulatory factor as sell as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I. J. Biol. Chem. 277 (2002) 35920-35931
26. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20 (1998) 709-726
27. Tyler W.J., Alonso M., Bramham C.R., and Pozzo-Miller L.D. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn. Mem. 9 (2002) 224-237