Drosophila homologs of FANCD2 and FANCL function in DNA repair

DNA Repair

Volumn 5, Issue 11, 2006, Pages 1317-1326

  Marek, Lorri R ^a   Bale, Allen E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle; Chromosome abnormalities; Cross linking agents; Fanconi anemia; Hypermutability

Indexed keywords

FANCONI ANEMIA GROUP D2 PROTEIN; FANCONI ANEMIA GROUP L PROTEIN; GENE PRODUCT; PROTEIN; PROTEIN FANCM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DROSOPHILA; FANCONI ANEMIA; FUNCTIONAL GENOMICS; FUNCTIONAL PROTEOMICS; GENE FUNCTION; GENETIC TRANSDUCTION; INDUCED MUTATION; IONIZING RADIATION; KNOCKOUT GENE; MAMMAL CELL; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; UBIQUITINATION;

ANIMALS; CELL CYCLE; CROSS-LINKING REAGENTS; DNA REPAIR; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP L PROTEIN; LARVA; MECHLORETHAMINE; MUTATION; RADIATION, IONIZING; UBIQUITIN;

MAMMALIA;

EID: 33749989371     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2006.05.044     Document Type: Article

References (37)

1. D'Andrea A.D., and Grompe M. The Fanconi anaemia/BRCA pathway. Nat. Rev. Cancer 3 (2003) 23-34
2. Joenje H., and Patel K.J. The emerging genetic and molecular basis of Fanconi anaemia. Nat. Rev. Genet. 2 (2001) 446-457
3. Rosselli F., Briot D., and Pichierri P. The Fanconi anemia pathway and the DNA interstrand cross-links repair. Biochimie 85 (2003) 1175-1184
4. Garcia-Higuera I., Kuang Y., Naf D., Wasik J., and D'Andrea A.D. Fanconi anemia proteins FANCA, FANCC and FANCG/XRCC9 interact in a functional nuclear complex. Mol. Cell. Biol. 19 (1999) 4866-4873
5. Meetei A.R., Sechi S., Wallisch M., Yang D., Young M.K., Joenje H., Hoatlin M.E., and Wang W. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol. Cell. Biol. 23 (2003) 3417-3426
6. Meetei A.R., de Winter J.P., Medhurst A.L., Wallisch M., Waisfisz Q., van de Vrugt H.J., Oostra A.B., Yan Z., Ling C., Bishop C.E., Hoatlin M.E., Joenje H., and Wang W. A novel ubiquitin ligase is deficient in Fanconi anemia. Nat. Genet. 35 (2003) 165-170
7. Meetei A.R., Yan Z., and Wang W. FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination. Cell Cycle 3 (2004) 179-181
8. Garcia-Higuera I., Taniguchi T., Ganesan S., Meyn M.S., Timmers C., Hejna J., Grompe M., and D'Andrea A.D. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell 7 (2001) 249-262
9. Taniguchi T., Garcia-Higuera I., Andreassen P.R., Gregory R.C., Grompe M., and D'Andrea A.D. S-phase-specific interaction of the Fanconi anemia protein, FANCD2 with BRCA1 and RAD51. Blood 100 (2002) 2414-2420
10. Taniguchi T., Garcia-Higuera I., Xu B., Andreassen P.R., Gregory R.C., Kim S.T., Lane W.S., Kastan M.B., and D'Andrea A.D. Convergence of the Fanconi anemia and ataxia telangiectasia signaling pathways. Cell 109 (2002) 459-472
11. Meetei A.R., Medhurst A.L., Ling C., Xue Y., Singh T.R., Bier P., Steltenpool J., Stone S., Dokal I., Mathew C.G., Hoatlin M., Joenje H., de Winter J.P., and Wang W. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat. Genet. 37 (2005) 958-963
12. Castillo V., Cabre O., Marcos R., and Surralles J. Molecular cloning of the Drosophila Fanconi anaemia gene FANCD2 cDNA. DNA Repair (Amst.) 2 (2003) 751-758
13. Timmers C., Taniguchi T., Hejna J., Reifsteck C., Lucas L., Bruun D., Thayer M., Cox B., Olson S., D'Andrea A.D., Moses R., and Grompe M. Positional cloning of a novel Fanconi anemia gene, FANCD2. Mol. Cell 7 (2001) 241-248
14. Lee Y.S., and Carthew R.W. Making a better RNAi vector for Drosophila: use of intron spacers. Methods 30 (2003) 322-329
15. Brand A.H., and Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118 (1993) 401-415
16. Busygina V., Suphapeetiporn K., Marek L.R., Stowers R.S., Xu T., and Bale A.E. Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. Hum. Mol. Genet. 13 (2004) 2399-2408
17. Silva E., Tiong S., Pedersen M., Homola E., Royou A., Fasulo B., Siriaco G., and Campbell S.D. ATM is required for telomere maintenance and chromosome stability during Drosophila development. Curr. Biol. 14 (2004) 1341-1347
18. Jaklevic B.R., and Su T.T. Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae. Curr. Biol. 14 (2004) 23-32
19. Polo S., Sigismund S., Faretta M., Guidi M., Capua M.R., Bossi G., Chen H., De Camilli P., and Di Fiore P.P. A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature 416 (2002) 451-455
20. Hanson H., Mathew C.G., Docherty Z., and Mackie C. Ogilvie telomere shortening in Fanconi anaemia demonstrated by a direct FISH approach. Cytogenet. Cell Genet. 93 (2001) 203-206
21. Callen E., Samper E., Ramirez M.J., Creus A., Marcos R., Ortega J.J., Olive T., Badell I., Blasco M.A., and Surralles J. Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia. Hum. Mol. Genet. 11 (2002) 439-444
22. Leteurtre F., Li X., Guardiola P., Le Roux G., Sergere J.C., Richard P., Carosella E.D., and Gluckman E. Accelerated telomere shortening and telomerase activation in Fanconi's anaemia. Br. J. Haematol. 105 (1999) 883-893
23. Siriaco G.M., Cenci G., Haoudi A., Champion L.E., Zhou C., Gatti M., and Mason J.M. Telomere elongation (Tel), a new mutation in Drosophila melanogaster that produces long telomeres. Genetics 160 (2002) 235-245
24. Papadopoulo D., Guillouf C., Mohrenweiser H., and Moustacchi E. Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 8383-8387
25. Sala-Trepat M., Boyse J., Richard P., Papadopoulo D., and Moustacchi E. Frequencies of HPRT-lymphocytes and glycophorin A variants erythrocytes in Fanconi anemia patients, their parents and control donors. Mutat. Res. 289 (1993) 115-126
26. Niedzwiedz W., Mosedale G., Johnson M., Ong C.Y., Pace P., and Patel K.J. The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol. Cell 15 (2004) 607-620
27. Xu T., Wang W., Zhang S., Stewart R.A., and Yu W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121 (1995) 1053-1063
28. Hay B.A., Huh J.R., and Guo M. The genetics of cell death: approaches, insights and opportunities in Drosophila. Nat. Rev. Genet. 5 (2004) 911-922
29. Melnikova L., and Georgiev P. Drosophila telomeres: the non-telomerase alternative. Chromosome Res. 13 (2005) 431-441
30. Thyagarajan B., and Campbell C. Elevated homologous recombination activity in Fanconi anemia fibroblasts. J. Biol. Chem. 272 (1997) 23328-23333
31. Matsushita N., Kitao H., Ishiai M., Nagashima N., Hirano S., Okawa K., Ohta T., Yu D.S., McHugh P.J., Hickson I.D., Venkitaraman A.R., Kurumizaka H., and Takata M. A FANCD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair. Mol. Cell 19 (2005) 841-847
32. Oikemus S.R., McGinnis N., Queiroz-Machado J., Tukachinsky H., Takada S., Sunkel C.E., and Brodsky M.H. Drosophila ATM/telomere fusion is required for telomeric localization of HP1 and telomere position effect. Genes Develop. 18 (2004) 1850-1861
33. Ciapponi L., Cenci G., Ducau J., Flores C., Johnson-Schlitz D., Gorski M.M., Engels W.R., and Gatti M. The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Curr. Biol. 14 (2004) 1360-1366
34. Houghtaling S., Timmers C., Noll M., Finegold M.J., Jones S.N., Meyn M.S., and Grompe M. Epithelial cancer in Fanconi anemia complementation group D2 (FANCD2) knockout mice. Genes Develop. 17 (2003) 2021-2035
35. Cheng N.C., van de Vrugt H.J., van der Valk M.A., Oostra A.B., Krimpenfort P., de Vries Y., Joenje H., Berns A., and Arwert F. Mice with a targeted disruption of the Fanconi anemia homolog FANCA. Hum. Mol. Genet. 9 (2000) 1805-1811
36. Whitney M.A., Royle G., Low M.J., Kelly M.A., Axthelm M.K., Reifsteck C., Olson S., Braun R.E., Heinrich M.C., Rathbun R.K., Bagby G.C., and Grompe M. Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood 88 (1996) 49-58
37. Yang Y., Kuang Y., De Oca R.M., Hays T., Moreau L., Lu N., Seed B., and D'Andrea A.D. Targeted disruption of the murine Fanconi anemia gene, FANCG/XRCC9. Blood 98 (2001) 3435-3440