Topical antiviral siRNA: A practical siRNA microbicide?

Gene Therapy

Volumn 13, Issue 21, 2006, Pages 1493-1494

  Rossi, J J ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; GLYCOPROTEIN B; GREEN FLUORESCENT PROTEIN; MICROBICIDE; RNA; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; BACTERIAL GENETICS; CELL DEATH; DENDRITIC CELL; DISEASE MODEL; DRUG EFFICACY; DRUG TARGETING; FEMALE; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; INHIBITION KINETICS; MACROPHAGE; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; RNA INTERFERENCE; SEXUALLY TRANSMITTED DISEASE; SURVIVAL RATE; T LYMPHOCYTE; TARGET CELL; TREATMENT DURATION; VIRUS SHEDDING; WART VIRUS;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIVIRAL AGENTS; COST-BENEFIT ANALYSIS; FEMALE; GENE SILENCING; GENE THERAPY; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; HUMANS; MICE; RNA INTERFERENCE; RNA, SMALL INTERFERING; VIRUS REPLICATION;

EID: 33749985477     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302764     Document Type: Note

References (10)

1. Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 2006; 439: 89-94.
2. Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell 2005; 123: 631-640.
3. Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD. Passenger-strand cleavage facilitates assembly of siRNA into Ago2- containing RNAi enzyme complexes. Cell 2005; 123: 607-620.
4. Miyoshi K, Tsukumo H, Nagami T, Siomi H, Siomi MC. Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev 2005; 19: 2837-2848.
5. Hannon GJ, Rossi JJ. Unlocking the potential of the human genome with RNA interference. Nature 2004; 431: 371-378.
6. Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 2005; 65: 8984-8992.
7. Morrissey DV, Lockridge JA, Shaw L, Blanchard K, Jensen K, Breen W et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat Biotechnol 2005; 23: 1002-1007.
8. Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn DM et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol 2005; 23: 709-717.
9. Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 2004; 432: 173-178.
10. Zhang W, Yang H, Kong X, Mohapatra S, San Juan-Vergara H, Hellermann G et al. Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Nat Med 2005; 11: 56-62.