Lauriston S. Taylor lecture: Nontargeted effects of radiation: Implications for low-dose exposures

Health Physics

Volumn 91, Issue 5, 2006, Pages 416-426

  Little, John B ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Biological indicators; Health effects; National Council on Radiation Protection and Measurements; Radiation, ionizing

Indexed keywords

DNA;

BYSTANDER EFFECT; CARCINOGENESIS; CELL COMMUNICATION; CELL NUCLEUS; CHROMOSOME ABERRATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; DNA RECOMBINATION; DNA REPAIR; GAP JUNCTION; GENE EXPRESSION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IONIZING RADIATION; MUTATION; MUTATION RATE; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; SIGNAL TRANSDUCTION;

BYSTANDER EFFECT; CELL PHYSIOLOGICAL PHENOMENA; CELL PHYSIOLOGY; CHROMOSOME ABERRATIONS; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENVIRONMENTAL EXPOSURE; GENOMIC INSTABILITY; RADIATION DOSAGE; RADIATION, IONIZING;

EID: 33749858414     PISSN: 00179078     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.HP.0000232847.23192.3e     Document Type: Conference Paper

References (17)

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2. Azzam EI, de Toledo SM, Spitz DR, Little JB. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res 62:5436-5442; 2002.
3. Azzam EI, de Toledo SM, Little JB. Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Res 63:7128-7135; 2003.
4. Hanawalt PC. DNA repair processes: an overview. In: Nichols WW, Murphy DG, eds. DNA repair processes. Miami, FL: Symposia Specialists; 1977: 1-19.
5. Huo L, Nagasawa H, Little JB. HPRT mutants induced in bystander cells by very low fluences of alpha particles result primarily from point mutations. Radiat Res 156:521-525; 2001.
6. Little JB. Radiation carcinogenesis. Carcinogenesis 21:397-404; 2000.
7. Little JB. Genomic instability and bystander effects: a historical perspective. Oncogene 22:6978-6987; 2003.
8. Little JB, Nagasawa H, Li GC, Chen DJ. Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiat Res 159:262-267; 2003.
9. Loeb LA, Loeb KR, Anderson JP. Multiple mutations and cancer. Proc Natl Acad Sci USA 100:776-781; 2003.
10. Morgan WF. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat Res 159:567-580; 2003.
11. Nagasawa H, Little JB. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res 52:6394-6396; 1992.
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13. Nagasawa H, Cremesti A, Kolesnick R, Fuks Z, Little JB. Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer Res 62:2531-2534; 2002.
14. Nagasawa H, Huo L, Little JB. Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells. Int J Radiat Biol 79:35-41; 2003.
15. Nagasawa H, Peng Y, Wilson PF, Lio Y-C, Chen DJ, Bedford JS, Little JB. Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations. Radiat Res 164:141-147; 2005.
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