메뉴 건너뛰기




Volumn 5, Issue 18, 2006, Pages 2072-2076

EGFR targeted therapy: View from biological standpoint

Author keywords

Apoptosis; Cell growth; Cell survival; EGFR mutant; EGFR mutant targeted therapy; Wt EGFR; Wt EGFR targeted therapy

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB;

EID: 33749677330     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.18.3277     Document Type: Review
Times cited : (27)

References (44)
  • 1
    • 0037429652 scopus 로고    scopus 로고
    • ErbB-targeted therapeutic approaches in human cancer
    • Arteaga CL. ErbB-targeted therapeutic approaches in human cancer. Exp Cell Res 2003; 284:122-30.
    • (2003) Exp Cell Res , vol.284 , pp. 122-130
    • Arteaga, C.L.1
  • 2
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA. ERBB receptors and cancer: The complexity of targeted inhibitors. Nat Rev Cancer 2005; 5:341-54.
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 3
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn J, Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 2000; 19:6550-65.
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 4
    • 0027159063 scopus 로고
    • Differential expression of the epidermal growth factor receptor and its ligands in primary nonsmall cell lung cancers and adjacent benign lung
    • Rusch V, Baselga J, Cordon-Cardo C, Orazem J, Zaman M, Hoda S, McIntosh J, Kurie J, Dmitrovsky E. Differential expression of the epidermal growth factor receptor and its ligands in primary nonsmall cell lung cancers and adjacent benign lung. Cancer Res 1993; 53:2379-85.
    • (1993) Cancer Res , vol.53 , pp. 2379-2385
    • Rusch, V.1    Baselga, J.2    Cordon-Cardo, C.3    Orazem, J.4    Zaman, M.5    Hoda, S.6    McIntosh, J.7    Kurie, J.8    Dmitrovsky, E.9
  • 5
    • 19844362355 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in the treatment of nonsmall-cell lung cancer
    • Giaccone G. Epidermal growth factor receptor inhibitors in the treatment of nonsmall-cell lung cancer. J Clin Oncol 2005; 23:3235-42.
    • (2005) J Clin Oncol , vol.23 , pp. 3235-3242
    • Giaccone, G.1
  • 6
    • 17844390172 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and nonsmall-cell lung cancer: Current knowledge and future directions
    • Pao W, Miller VA. Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and nonsmall-cell lung cancer: Current knowledge and future directions. J Clin Oncol 2005; 23:2556-68.
    • (2005) J Clin Oncol , vol.23 , pp. 2556-2568
    • Pao, W.1    Miller, V.A.2
  • 7
    • 13844316734 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors and the dawn of molecular cancer therapeutics
    • Tibes R, Trent J, Kurzrock R. Tyrosine kinase inhibitors and the dawn of molecular cancer therapeutics. Annu Rev Pharmacol Toxicol 2005; 45:357-84.
    • (2005) Annu Rev Pharmacol Toxicol , vol.45 , pp. 357-384
    • Tibes, R.1    Trent, J.2    Kurzrock, R.3
  • 13
    • 33646345615 scopus 로고    scopus 로고
    • Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer
    • Suzuki M, Shigematsu H, Iizasa T, Hiroshima K, Nakatani Y, Minna JD, Gazdar AF, Fujisawa T. Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer. Cancer 2006; 106:2200-7.
    • (2006) Cancer , vol.106 , pp. 2200-2207
    • Suzuki, M.1    Shigematsu, H.2    Iizasa, T.3    Hiroshima, K.4    Nakatani, Y.5    Minna, J.D.6    Gazdar, A.F.7    Fujisawa, T.8
  • 21
    • 23844444080 scopus 로고    scopus 로고
    • An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor
    • Kobayashi S, Ji H, Yuza Y, Meyerson M, Wong KK, Tenen DG, Halmos B. An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor. Cancer Res 2005; 65:7096-101.
    • (2005) Cancer Res , vol.65 , pp. 7096-7101
    • Kobayashi, S.1    Ji, H.2    Yuza, Y.3    Meyerson, M.4    Wong, K.K.5    Tenen, D.G.6    Halmos, B.7
  • 22
    • 33644507072 scopus 로고    scopus 로고
    • Multiple oncogenic changes (K-RAS(V12), p53 knock-down, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
    • Sato M, Vaughan MB, Girard L, Peyton M, Lee W, Shames DS, Ramirez RD, Sunaga N, Gazdar AF, Shay JW, Minna JD. Multiple oncogenic changes (K-RAS(V12), p53 knock-down, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res 2006; 66:2116-28.
    • (2006) Cancer Res , vol.66 , pp. 2116-2128
    • Sato, M.1    Vaughan, M.B.2    Girard, L.3    Peyton, M.4    Lee, W.5    Shames, D.S.6    Ramirez, R.D.7    Sunaga, N.8    Gazdar, A.F.9    Shay, J.W.10    Minna, J.D.11
  • 24
    • 33744814638 scopus 로고    scopus 로고
    • Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to downregulation of the receptors
    • Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to downregulation of the receptors. Genes Dev 2006; 20:1496-510.
    • (2006) Genes Dev , vol.20 , pp. 1496-1510
    • Politi, K.1    Zakowski, M.F.2    Fan, P.D.3    Schonfeld, E.A.4    Pao, W.5    Varmus, H.E.6
  • 26
    • 33644500489 scopus 로고    scopus 로고
    • Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants
    • Chen YR, Fu YN, Lin CH, Yang ST, Hu SF, Chen YT, Tsai SF, Huang SF. Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants. Oncogene 2006; 25:1205-15.
    • (2006) Oncogene , vol.25 , pp. 1205-1215
    • Chen, Y.R.1    Fu, Y.N.2    Lin, C.H.3    Yang, S.T.4    Hu, S.F.5    Chen, Y.T.6    Tsai, S.F.7    Huang, S.F.8
  • 27
    • 5644293135 scopus 로고    scopus 로고
    • Gefitinib induces apoptosis in the EGFRL858R nonsmall-cell lung cancer cell line H3255
    • Tracy S, Mukohara T, Hansen M, Meyerson M, Johnson BE, Janne PA. Gefitinib induces apoptosis in the EGFRL858R nonsmall-cell lung cancer cell line H3255. Cancer Res 2004; 64:7241-4.
    • (2004) Cancer Res , vol.64 , pp. 7241-7244
    • Tracy, S.1    Mukohara, T.2    Hansen, M.3    Meyerson, M.4    Johnson, B.E.5    Janne, P.A.6
  • 28
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R, Bell DW, Haber DA, Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 2004; 305:1163-7.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 29
    • 33746154236 scopus 로고    scopus 로고
    • Nonsmall-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272
    • Shimamura T, Ji H, Minami Y, Thomas RK, Lowell AM, Shah K, Greulich H, Glatt KA, Meyerson M, Shapiro GI, Wong KK. Nonsmall-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272. Cancer Res 2006; 66:6487-91.
    • (2006) Cancer Res , vol.66 , pp. 6487-6491
    • Shimamura, T.1    Ji, H.2    Minami, Y.3    Thomas, R.K.4    Lowell, A.M.5    Shah, K.6    Greulich, H.7    Glatt, K.A.8    Meyerson, M.9    Shapiro, G.I.10    Wong, K.K.11
  • 32
    • 3543122916 scopus 로고    scopus 로고
    • Predicting sensitivity of nonsmall-cell lung cancer to gefitinib: Is there a role for P-Akt?
    • Pao W, Miller VA, Venkatraman E, Kris MG. Predicting sensitivity of nonsmall-cell lung cancer to gefitinib: Is there a role for P-Akt? J Natl Cancer Inst 2004; 96:1117-1119.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1117-1119
    • Pao, W.1    Miller, V.A.2    Venkatraman, E.3    Kris, M.G.4
  • 33
    • 10644255612 scopus 로고
    • Re: Akt phosphorylation and gefitinib efficacy in patients with advanced nonsmall-cell lung cancer
    • (author reply 1795-6, 2004)
    • Tsurutani J, Dennis PA. Re: Akt phosphorylation and gefitinib efficacy in patients with advanced nonsmall-cell lung cancer. J Natl Cancer Inst 1795; 96, (author reply 1795-6, 2004).
    • (1795) J Natl Cancer Inst , vol.96
    • Tsurutani, J.1    Dennis, P.A.2
  • 34
    • 17244374958 scopus 로고    scopus 로고
    • Re: Akt phosphorylation and gefitinib efficacy in patients with advanced nonsmall-cell lung cancer
    • (author reply 462-3)
    • de Braud F, De Pas T, Spaggiari L, Veronesi G, Curigliano G, Noberasco C, Pelosi G. Re: Akt phosphorylation and gefitinib efficacy in patients with advanced nonsmall-cell lung cancer. J Natl Cancer Inst 2005; 97:461-2, (author reply 462-3).
    • (2005) J Natl Cancer Inst , vol.97 , pp. 461-462
    • De Braud, F.1    De Pas, T.2    Spaggiari, L.3    Veronesi, G.4    Curigliano, G.5    Noberasco, C.6    Pelosi, G.7
  • 35
    • 25444505624 scopus 로고    scopus 로고
    • Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression
    • Jiang J, Greulich H, Janne PA, Sellers WR, Meyerson M, Griffin JD. Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression. Cancer Res 2005; 65:8968-74.
    • (2005) Cancer Res , vol.65 , pp. 8968-8974
    • Jiang, J.1    Greulich, H.2    Janne, P.A.3    Sellers, W.R.4    Meyerson, M.5    Griffin, J.D.6
  • 38
    • 32944481596 scopus 로고    scopus 로고
    • Clinical course of patients with nonsmall cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
    • Riely GJ, Pao W, Pham D, Li AR, Rizvi N, Venkatraman ES, Zakowski MF, Kris MG, Ladanyi M, Miller VA. Clinical course of patients with nonsmall cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 2006; 12:839-44.
    • (2006) Clin Cancer Res , vol.12 , pp. 839-844
    • Riely, G.J.1    Pao, W.2    Pham, D.3    Li, A.R.4    Rizvi, N.5    Venkatraman, E.S.6    Zakowski, M.F.7    Kris, M.G.8    Ladanyi, M.9    Miller, V.A.10
  • 40
    • 28444468174 scopus 로고    scopus 로고
    • Inhibition of EGFR signaling: All mutations are not created equal
    • Gazdar AF, Minna JD. Inhibition of EGFR signaling: All mutations are not created equal. PLoS Med 2005; 2:e377.
    • (2005) PLoS Med , vol.2
    • Gazdar, A.F.1    Minna, J.D.2
  • 43
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005; 2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 44
    • 25444490894 scopus 로고    scopus 로고
    • Overcoming acquired resistance to Iressa/Tarceva with inhibitors of a different class
    • Haber DA, Settleman J. Overcoming acquired resistance to Iressa/Tarceva with inhibitors of a different class. Cell Cycle 2005; 4:1057-9.
    • (2005) Cell Cycle , vol.4 , pp. 1057-1059
    • Haber, D.A.1    Settleman, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.