Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteins

BMC Cell Biology

Volumn 7, Issue , 2006, Pages

  Bergman, Lee M ^a   Morris, Laila ^a   Darley, Matthew ^a   Mirnezami, Alexander H ^a   Gunatilake, Samal C ^a   Blaydes, Jeremy P ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; C TERMINAL BINDING PROTEIN 1; C TERMINAL BINDING PROTEIN 2; CELL PROTEIN; HETERODIMER; HISTONE ACETYLTRANSFERASE PCAF; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NONHUMAN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REGULATORY MECHANISM;

ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEUS; DNA-BINDING PROTEINS; EYE PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NUCLEAR LOCALIZATION SIGNALS; PHYLOGENY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; SEQUENCE ALIGNMENT;

EID: 33749635494     PISSN: 14712121     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-7-35     Document Type: Article

References (36)

1. Boyd JM, Subramanian T, Schaeper U, La Regina M, Bayley S, Chinnadurai G: A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. Embo J 1993, 12(2):469-478.
2. Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y: Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 2003, 422(6933):735-738.
3. Koipally J, Georgopoulos K: Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J Biol Chem 2000, 275(26):19594-19602.
4. Sewalt RG, Gunster MJ, van der Vlag J, Satijn DP, Otte AP: C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. Mol Cell Biol 1999, 19(1):777-787.
5. Kim JH, Cho EJ, Kim ST, Youn HD: CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain, Nat Struct Mol Biol 2005, 15(5):432-438.
6. Hidalgo Carcedo C, Bonazzi M, Spano S, Turacchio G, Colanzi A, Luini A, Corda D: Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS. Science 2004, 305(5680):93-96.
7. Bonazzi M, Spano S, Turacchio G, Cericola C, Valente C, Colanzi A, Kweon HS, Hsu VW, Polishchuck EV, Polishchuck RS, Sallese M, Pulvirenti T, Corda D, Luini A: CtBP3/BARS drives membrane fission in dynamin-Independent transport pathways. Nat Cell Biol 2005, 7(7):570-580.
8. Spyer M, Allday MJ: The Transcriptional Co-Repressor C-Terminal Binding Protein (CtBP) Associates with Centrosomes During Mitosis. Cell Cycle 2006, 5(5):.
9. Schaeper U, Boyd JM, Verma S, Uhlmann E, Subramanian T, Chinnadurai G: Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc Natl Acad Sci U S A 1995, 92(23):10467-10471.
10. Subramanian T, La. Regina M, Chinnadurai G: Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a protein. Oncogene 1989, 4(4):415-420.
11. Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K, Hirai H: The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling., Blood 2001, 97(9):2815-2822.
12. Mirnezami AH, Campbell SJ, Darley M, Primrose JN, Johnson PW, Blaydes JP: Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription. Curr Biol 2003, 13(14):1234-1239.
13. Lin X, Liang YY, Sun B, Liang M, Shi Y, Brunicardi FC, Feng XH: Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol Cell Biol 2003, 23(24):9081-9093.
14. Hamada F, Bienz M: The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. Dev Cell 2004, 7(5):677-685.
15. Meloni AR, Smith EJ, Nevins JR: A mechanism for Rb/p 130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc Natl Acad Sci U S A 1999, 96(17):9574-9579.
16. Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH: Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 2003, 115(2):177-186.
17. Bergman LM, Blaydes JP: C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis. Apoptosis 2006, Epub Mar 13:.
18. Katsanis N, Fisher EM: A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. Genomics 1998, 47(2):294-299.
19. Schmitz F, Konigstorfer A, Sudhof TC: RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function. Neuron 2000, 28(3):857-872.
20. Spano S, Silletta MG, Colanzi A, Alberti S, Fiucci G, Valente C, Fusella A, Salmona M, Mironov A, Luini A, Corda D: Molecular cloning and functional characterization of brefeldin A-ADP-ribosylated substrate. A novel protein involved in the maintenance of the Golgi structure. J Biol Chem 1999, 274(25):17705-17710.
21. Chinnadurai G: CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol Cell 2002, 9(2):213-224.
22. Barnes CJ, Vadlamudi RK, Mishra SK, Jacobson RH, Li F, Kumar R: Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat Struct Biol 2003, 10(8):622-628.
23. Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B: Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. Embo J 1999, 18(12):3392-3403.
24. Deltour S, Pinte S, Guerardel C, Wasylyk B, Leprince D: The human candidate tumor suppressor gene HICI recruits CtBP through a degenerate GLDLSKK motif. Mol Cell Biol 2002, 22(13):4890-4901.
25. Riefler GM, Firestein BL: Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS. J Biol Chem 2001, 276(51):48262-48268.
26. Lin X, Sun B, Liang M, Liang YY, Gast A, Hildebrand J, Brunicardi FC, Melchior F, Feng XH: Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol Cell 2003, 11(5):1389-1396.
27. Zhao LJ, Subramanian T, Zhou Y, Chinnadurai G: Acetylation by p300 Regulates Nuclear Localization and Function of the Transcriptional Corepressor CtBP2. J Biol Chem 2006, 281(7):4183-4189.
28. Verger A, Quinlan KG, Crofts LA Spano S, Corda D, Kable EP, Braet F, Crossley M: Mechanisms Directing the Nuclear Localization of the CtBP Family Proteins. Mol Cell Biol 2006, 26(13):4882-4894.
29. PredictNLS server [http://cubic.bioc.columbia.edu/predictNLS/]
30. Alpatov R, Munguba GC, Caton P, Joo JH, Shi Y, Hunt ME, Sugrue SP: Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Mol Cell Biol 2004, 24(23):10223-10235.
31. Nardini M, Spano S, Cericola C, Pesce A, Massaro A, Millo E, Luini A, Corda D, Bolognesi M: CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission. Embo J 2003, 22(12):3122-3130.
32. Kagey MH, Melhuish TA, Wotton D: The polycomb protein Pc2 is a SUMO E3. Cell 2003, 113(1):127-137.
33. Zhao LJ, Subramanian T, Zhou Y, Chinnadurai G: Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2. J Biol Chem 2005.
34. Grooteclaes M, Deveraux Q, Hildebrand J, Zhang Q, Goodman RH, Frisch SM: C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc Natl Acad Sci U S A 2003, 100(8):4568-4573.
35. Hildebrand JD, Soriano P: Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol 2002, 22(15):5296-5307.
36. Wan L, Almers W, Chen W: Two ribeye genes in teleosts: the role of Ribeye in ribbon formation and bipolar cell development. J Neurosci 2005, 25(4):941-949.