Mechanism-based approaches for the reversal of drug neurobehavioral teratogenicity

Annals of the New York Academy of Sciences

Volumn 1074, Issue , 2006, Pages 659-671

  Yanai, Joseph ^a,b   Ben Shaanan, Tamar L ^a   Haimovitch, Hana ^a   Katz, Sophia ^a   Kazma, Meital ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

A10; Grafting of neural progenitors; Heroin; Hippocampal behavior; Hippocampal cholinergic innervation; Neurobehavioral teratogenicity; Nicotine therapy; PKC isoforms; Reversal therapies

Indexed keywords

CHOLINERGIC RECEPTOR; DIAMORPHINE; ENZYME; NICOTINE; PROTEIN KINASE C; TERATOGENIC AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIRTH DEFECT; CONFERENCE PAPER; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; HIPPOCAMPUS; MAZE TEST; MOLECULAR INTERACTION; MORRIS MAZE TEST; MOUSE; NEUROBEHAVIORAL TERATOGENICITY; NONHUMAN; PARASYMPATHETIC INNERVATION; PRESYNAPTIC NERVE; SEPTUM PELLUCIDUM; STEM CELL; TASK PERFORMANCE; TERATOGENICITY;

EID: 33749572217     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1369.066     Document Type: Conference Paper

References (62)

1. WERBOFF, J. & J.S. GOTTLIER. 1963. Drug in pregnancy: behavioral teratology. Obstet. Gynecol. Surv. 18: 420-423.
2. HUTCHINGS, D.E. 1978. Behavioral teratology: embryopathic and behavioral effects of drugs during pregancy. In Studies on the Development of Behavior and the Nervous System. Vol. 4, Early Influences. G. Gottlieb, Ed.: 7-34. Academic Press. New York.
3. YANAI, J. 1984. Preface. In Neurobehavioral Terarology. J. Yanai, Ed.: V-IX. Elsevier. Amsterdam.
4. BEER, A. et al. 2005. Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital. Neuropsychopharmacology 30: 156-165.
5. NORDBERG, A. & G. WAHLSTROM. 1980. Acute and chronic effects of barbiturates on regional turnover of acetylcholine in brain. Adv. Exp. Med. Biol. 126: 165-179.
6. NORDBERG, A. & G. WAHLSTROM. 1992. Cholinergic mechanisms in physical dependence on barbiturates, ethanol and benzodiazepines. J. Neural. Transm. Gen. Sect. 88: 199-221.
7. KEARNS, I.R. et al. 2001. Opioid receptor regulation of muscarinic acetylcholine receptor-mediated synaptic responses in the hippocampus. Neuropharmacology 41: 565-573.
8. LAPCHAK, P.A., D.M. ARAUJO & B. COLLIER. 1989. Regulation of endogenous acetylcholine release from mammalian brain slices by opiate receptors: hippocampus, striatum and cerebral cortex of guinea-pig and rat. Neuroscience 31: 313-325.
9. STEINGART, R.A. et al. 2000. Neural grafting reverses prenatal drug-induced alterations in hippocampal PKC and related behavioral deficits. Brain Res. Dev. Brain Res. 125:9-19.
10. IZRAEL, M. et al. 2004. Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. J. Neurosci. Res. 499-507.
11. KLEINBERGER, N. & J. YANAI. 1985. Early phenobarbital-induced alterations in hippocampal acetylcholinesterase activity and behavior. Brain Res. 354: 113-123.
12. ROGEL-FUCHS, Y. et al. 1992. Hippocampal cholinergic alterations and related behavioral deficits after early exposure to phe;nobarbital. Brain Res. Bull. 29: 1-6.
13. STEINGART, R.A. et al. 1998. Pre- and postsynaptic alterations in the septohippocampal cholinergic innervations after prenatal exposure to drugs. Brain Res. Bull. 46: 203-209.
14. KRISTOFIKOVA, Z. et al. 1995. (3H)hemicholinium-3 binding sites in postmortem brains of human patients with Alzheimer's disease and multi-infarct dementia. Exp. Gerontol. 30: 125-136.
15. SIMON, J.R., S. ATWEH & M.J. KUHAR. 1976. Sodium-dependent high affinity choline uptake: a regulatory step in the synthesis of acetylcholine. J. Neurochem. 26: 909-922.
16. ABU-ROUMI, M., M.E. NEWMAN & J. YANAI. 1996. Inositol phosphate formation in mice prenatally exposed to drugs: relation to muscarinic receptors and postreceptor effects. Brain Res. Bull. 40: 183-186.
17. YANAI, J. et al. 1992. Alterations in septohippocampal cholinergic innervations and related behaviors after early exposure to heroin and phencyclidine. Brain Res. Dev. Brain Res. 69: 207-214.
18. STEINGART, R.A. et al. 2000. Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: cellular mechanisms and the reversal of deficits by neural grafts. Brain Res. Dev. Brain Res. 122: 125-133.
19. SHAHAK, H., T.A. SLOTKIN & J. YANAI. 2003. Alterations in PKCγ in the mouse hippocampus after prenatal exposure to heroin: a link from cell signaling to behavioral outcome. Brain Res. Dev. Brain Res. 140: 117-125.
20. YANIV, S.P., Z. NAOR & J. YANAI. 2004. Prenatal heroin exposure alters cholinergic receptor stimulated translocation and basal levels of the PKCβII and PKCγ isoforms. Brain Res. Bull. 63: 339-349.
21. BJORKLUND, A. & U. STENEVI. 1979. Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. 177: 555-560.
22. PERLOW, M.J. et al. 1979. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 204: 643-647.
23. WANG, X. et al. 2004. Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson's disease. Int. J. Dev. Neurosci. 22: 175-183.
24. BJORKLUND, L.M. et al. 2002. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc. Natl. Acad. Sci. USA 99: 2344-2349.
25. ANDERSEN, J.D. & B. POUZET. 2004. Spatial memory deficits induced by perinatal treatment of rats with PCP and reversal effect of D-serine. Neuropsychopharmacology 29: 1080-1090.
26. THOMAS, J.D., S.L. FLEMING & E.P. RILEY. 2002. Administration of low doses of MK-801 during ethanol withdrawal in the developing rat pup attenuates alcohol's teratogenic effects. Alcohol Clin. Exp. Res. 26: 1307-1313.
27. THOMAS, J.D. et al. 2004. Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits. Psychopharmacology (Berl.) 175: 189-195.
28. ZHOU, M. & J.B. SUSZKIW. 2004. Nicotine attenuates spatial learning deficits induced in the rat by perinatal lead exposure. Brain Res. 999: 142-147.
29. CHRISTIE, B.R. et al. 2005. Voluntary exercise rescues deficits in spatial memory and long-term potentiation in prenatal ethanol-exposed male rats. Eur. J. Neurosci. 21: 1719-1726.
30. WOLANSKY, M.J. et al. 2004. Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug. Neurotoxicol. Teratol. 26: 561-569.
31. WHITE, H.K. & E.D. LEVIN. 1999. Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease. Psychopharmacology (Berl.) 143: 158-165.
32. WHITE, H.K. & E.D. LEVIN. 2004. Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment. Psychopharmacology (Berl.) 171: 465-471.
33. WILSON, A.L. et al. 1995. Nicotine patches in Alzheimer's disease: pilot study on learning, memory, and safety. Pharmacol. Biochem. Behav. 51: 509-514.
34. YANAI, J. et al. 1989. Dopaminergic denervation reverses behavioral deficits induced by prenatal exposure to phenobarbital. Brain Res. Dev. Brain Res. 48: 255-261.
35. YANAI, J. et al. 1987. CNS changes after early barbiturate exposure: mechanisms and reversal. In Functional Teratogenesis. T. Fujii & P. Adams, Eds.: 121-130. Tokyo-University Press. Tokyo.
36. YANAI, J. et al. 1993. Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways. Neuropharmacology 32: 113-117.
37. ROBINSON, S.E. et al. 1979. Dopaminergic control of the septal-hippocampal cholinergic pathway. J. Pharmacol. Exp. Ther. 208: 476-479.
38. COSTA, E. et al. 1983. The transsynaptic regulation of the septal-hippocampal cholinergic neurons. Life Sci. 32: 165-179.
39. JAFFARD, R. et al. 1985. The cholinergic septohippocampal pathway, learning and memory. In Brain Plasticity Learning and Memory. P. Schmitt & J. Dalrymple-Alford, Eds.: 167-181. Plenum. New York.
40. GALEY, D. et al. 1984. Improvement in spontaneous and acquired spatial behaviors following lesions of septal dopaminergic afferents in mice: possible relations with hippocampal cholinergic activity. C. R. Acad. Sci. III. 299: 681-686.
41. YANAI, J. & C.G. PICK. 1988. Neuron transplantation reverses phenobarbital-induced behavioral birth defects in mice. Int. J. Dev. Neurosci. 6: 409-416.
42. ROGEL-FUCHS, Y., E.A. ZAHALKA & J. YANAI. 1994. Reversal of early phenobarbital-induced cholinergic and related behavioral deficits by neuronal grafting. Brain Res. Bull. 33: 273-279.
43. YANAI, J. et al. 2005. Neural progenitors for the reversal of heroin neurobehavioral teratogenicity. Proceedings of the 3rd Annual Meeting of the International Society for Stem Cell Research 259.
44. HAGELL, P. et al. 2002. Dyskinesias following neural transplantation in Parkinson's disease. Nat. Neurosci. 5: 627-628.
45. BEN-HUR, T. et al. 2003. Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis. Glia 41: 73-80.
46. BRUSTLE, O., U. MASKOS & R.D. MCKAY. 1995. Host-guided migration allows targeted introduction of neurons into the embryonic brain. Neuron 15: 1275-1285.
47. BEN-HUR, T. et al. 2003. Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells. Mol. Cell Neurosci. 24: 623-631.
48. STUMM, R.K. et al. 2003. CXCR4 regulates interneuron migration in the developing neocortex. J. Neurosci. 23: 5123-5130.
49. BAGRI, A. et al. 2002. The chemokine SDF1 regulates migration of dentate granule cells. Development 129: 4249-4260.
50. BULTE, J.W. et al. 2003. MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain. Magn. Reson. Med. 50: 201-205.
51. YANAI, J. et al. 1995. Embryonic cultures but not embryos transplanted to the mouse's brain grow rapidly without immunosuppression. Int. J. Neurosci. 81: 21-26.
52. BEN-HUR, T., O. EINSTEIN & J.W. BULTE. 2005. Stem cell therapy for myelin diseases. Curr. Drug Targets 6: 3-19.
53. REUBINOFF, B.E. et al. 2001. Neural progenitors from human embryonic stem cells. Nat. Biotechnol. 19: 1134-1140.
54. JELTSCH, H. et al. 2003. Transplantation of neurospheres after granule cell lesions in rats: cognitive improvements despite no long-term immunodetection of grafted cells. Behav. Brain Res. 143: 177-191.
55. ENGLUND, U. et al. 2002. Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proc. Natl. Acad. Sci. USA 99: 17089-17094.
56. SNYDER, E.Y. & J.F. LORING. 2005. A role for stem cell biology in the physiological and pathological aspects of aging. J. Am. Geriatr. Soc. 53: S287-S291.
57. TODA, H. et al. 2001. Grafting neural stem cells improved the impaired spatial recognition in ischemic rats. Neurosci. Lett. 316: 9-12.
58. ZHANG, H. et al. 2004. Elevation of NMDAR after transplantation of neural stem cells. Neuroreport 15: 1739-1743.
59. BRADBURY, E.J. et al. 1995. Astrocyte transplants alleviate lesion induced memory deficits independently of cholinergic recovery. Neuroscience 65: 955-972.
60. VAN DER ZEE, E.A., P.G. LUITEN & J.F. DISTERHOFT. 1997. Learning-induced alterations in hippocampal PKC-immunoreactivity: a review and hypothesis of its functional significance. Prog. Neuropsychopharmacol. Biol. Psychiatry 21: 531-572.
61. OUREDNIK, J. et al. 2002. Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nat. Biotechnol. 20: 1103-1110.
62. YANAI, J., T. BEN-HUR & T. BEN-SHAANAN. 2006. Transplantation of neural progenitors into the brain of mice exposed prenatally to heroin induces proliferation of endogenous neural precursors. Neurotoxicol. Teratol. In Press.