Neural grafting reverses prenatal drug-induced alterations in hippocampal PKC and related behavioral deficits

Developmental Brain Research

Volumn 125, Issue 1-2, 2000, Pages 9-19

  Steingart, Ruth A ^a   Silverman, William F ^b   Barron, Susan ^c   Slotkin, Theodore A ^d   Awad, Yaser ^a   Yanai, Joseph ^a,d  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c UNIVERSITY OF KENTUCKY   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Choline transporter; Correlation; Early exposure; Eight arm maze; Heroin; Neural grafting; Phenobarbital; Protein kinase C

Indexed keywords

CARBACHOL; DIAMORPHINE; HEMICHOLINIUM 3; PHENOBARBITAL; PROTEIN KINASE C;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FEMALE; FETAL TISSUE TRANSPLANTATION; HIPPOCAMPUS; MALE; MAZE TEST; MOUSE; NERVE TRANSPLANTATION; NEUROTOXICITY; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN TISSUE TRANSPLANTATION; CARBACHOL; CARRIER PROTEINS; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC AGENTS; CHOLINERGIC AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; FETAL TISSUE TRANSPLANTATION; HEMICHOLINIUM 3; HEROIN; HIPPOCAMPUS; MALE; MAZE LEARNING; MICE; NARCOTICS; NERVE TISSUE PROTEINS; PHENOBARBITAL; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORT PROTEINS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROTEIN KINASE C; SYMPORTERS; SYNAPSES;

EID: 0034731499     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(00)00123-1     Document Type: Article

References (55)

1. Modified hippocampal long-term potentiation in PKC gamma-mutant mice
2. Inositol phosphate formation in mice prenatally exposed to drugs: Relation to muscarinic receptors and postreceptor effect
3. Translocation of protein kinase C activity may mediate hippocampal long-term potentiation
4. Neonatal alcohol exposure alters suckling performance in rat pups
5. Quantitative modeling and biology: The multivariate approach
6. Functional muscarinic supersensitivity in denervated rat hippocampus
7. Reformation of the severed septohippocampal cholinergic pathway in the adult rat by transplanted septal neurons
8. Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as criterion for intracerebral graft survival
9. Dopamine-acetylcholine interaction in the rat striatum: A dual-labeling immunocytochemical study
10. Determination of acetylcholine dynamics
11. Long-term potentiation as synaptic dialogue
12. Effects of prenatal alcohol on homing behavior, maternal responding and open-field activity in rats
13. Enhancement of hippocampally-mediated learning and protein kinase C activity by oxiracetam in learning-impaired DBA/2 mice
14. b-Adrenoceptor control of cardiac adenylyl cyclase during development: Agonist pretreatment in the neonate uniquely causes heterologous sensitization, not desensitization
15. High affinity choline transport and acetylCoA production in brain and their roles in the regulation of acetylcholine synthesis
16. Effects of hippocampal electrical stimulation on long-term memory and on cholinergic mechanisms in three inbred strains of mice
17. 3H] acetylcholine to muscarinic cholinergic receptors
18. Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties
19. 3H]Hemicholinium-3 binding sites in postmortem brains of human patients with Alzheimer's disease and multi-infarct dementia
20. Opioids and development: A perspective on experimental models and methods
21. The role of protein kinase C in long-term potentiation: A testable model
22. 3H]hemicholinium-3 binding sites in the rat brain
23. The use of isogenic and heterogenic mouse stock in behavioral research
24. Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the alpha subunit of the G-protein Gq
25. High-affinity transport of choline in neuronal tissue
26. Regulation and development of muscarinic receptor number and function
27. Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain
28. Protein kinase C activity in the hippocampus following spatial learning tasks in mice
29. Remembrance of places passed: Spatial memory in rats
30. Hormones, growth factors, and their receptors in normal and abnormal prenatal development
31. The behavioral and neuroanatomical effects of prenatal alcohol exposure in animals
32. Critical periods for behavioral anomalies in mice
33. Hippocampal cholinergic alterations and related behavioral deficits after early exposure to phenobarbital
34. Reversal of early phenobarbital-induced cholinergic and related behavioral deficits by neuronal grafting
35. 3H] hemicholinium-3 binding associated with neuronal choline uptake sites in rat brain membranes
36. Development of high affinity choline uptake and associated acetylcholine synthesis in the rat fascia dentate
37. Sodium-dependent high affinity choline uptake: A regulatory step in the synthesis of acetylcholine
38. Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: Cellular mechanisms and the reversal of deficits by neural grafts, Dev
39. Pre- and postsynaptic alterations in the septohippocampal cholinergic innervations after prenatal exposure to drugs
40. Intrahippocampal transplants of septal cholinergic neurons: High affinity choline uptake and spatial memory function
41. Prenatal morphine exposure induces age-related changes in seizure susceptibility in male rats
42. Studies on the effects of anticonvulsant drugs on the developing human brain
43. Translocation and activation of protein kinase C in striatal neurons in primary culture: Relationship to phorbol dibutyrate actions on the inositol phosphate generating system and neurotransmitter release
44. Preservation on place reversals in spatial swimming pool tasks: Further evidence for place learning in hippocampal rats
45. Preface
46. An animal model for the effect of barbiturate on the development of the central nervous system
47. Neuron transplantation reverses phenobarbital-induced behavioral birth defects in mice
48. Behavioral deficits and both pre- and postsynaptic cholinergic hyperactivity after early drug-exposure
49. Alterations in septohippocampal cholinergic innervation and related behavior after early exposure to heroin and phencyclidine
50. 10-septal dopaminergic pathways
51. An overview of the neurobehavioral sequelae of prenatal opioid exposure
52. Alterations in hippocampal hemicholinium-3 binding and related behavioural and biochemical changes after prenatal phenobarbitone exposure
53. Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: Differential effects on choline acetyltransferase activity and [3H]hemicholinium-3 binding
54. Differential development of cholinergic nerve terminal markers in rat brain regions: Implications for nerve terminal density, impulse activity and specific gene expression