Phase II trial of preoperative chemoradiation with a hyperfractionated radiation boost in locally advanced rectal cancer

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 29, Issue 5, 2006, Pages 435-441

  Movsas, Benjamin ^a   Diratzouian, Hasmik ^b   Hanlon, Alexandra ^b   Cooper, Harry ^b   Freedman, Gary ^b   Konski, Andre ^b   Sigurdson, Elin ^b   Hoffman, John ^b   Meropol, Neal J ^b   Weiner, Louis M ^b   Coia, Lawrence ^c   Lanciano, Rachelle ^d   Stein, Joanne ^b   Kister, Debra ^b   Eisenberg, Burton ^e  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c Department of Medicine Rutgers Health Community Medical Center Internal Medicine Residency Program   (United States)

^d Delaware County Memorial Hospital   (United States)

^e DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

Hyperfractionated boost; Preoperative chemoradiation; Rectal carcinoma

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BLOOD CELL COUNT; BLOOD TOXICITY; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CHEMORADIATION; CLINICAL ARTICLE; CLINICAL TRIAL; FIBROSIS; HUMAN; PHASE 2 CLINICAL TRIAL; PREOPERATIVE CARE; PROSPECTIVE STUDY; RADIATION DOSE FRACTIONATION; RECTUM CANCER; SURVIVAL RATE; TREATMENT FAILURE; TREATMENT PLANNING; TREATMENT RESPONSE; TUMOR VOLUME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; COMBINED MODALITY THERAPY; DOSE FRACTIONATION; FLUOROURACIL; HUMANS; MIDDLE AGED; PROSPECTIVE STUDIES; RADIOTHERAPY, HIGH-ENERGY; RECTAL NEOPLASMS; SURVIVAL ANALYSIS;

EID: 33749557201     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/01.coc.0000227480.41414.f2     Document Type: Article

References (31)

1. Minsky BD, Cohen AM, Kemeny N, et al. Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy. J Clin Oncol. 1992;10:79-84.
2. Wagman R, Minsky B, Cohen AM, et al. Sphincter preservation in rectal cancer with preoperative radiation therapy and coloanal anastomosis: long term follow up. Int J Radiat Oncol Biol Phys. 1998;42:51-57.
3. Minsky BD, Cohen AM, Kemeny N, et al. Combined modality therapy of rectal cancer: decreased acute toxicity with the preoperative approach. J Clin Oncol. 1992;10:1218-1224.
4. Kelsen DP, Hilaris B, Martini N. Neoadjuvant chemotherapy and surgery of cancer of the esophagus. Semin Surg Oncol. 1986;2:170-176.
5. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731-1740.
6. Fortier GA, Constable WC, Meyers H, et al. Preoperative radiation therapy for rectal cancer. An effective therapy in need of a clinical trial. Arch Surg. 1986;121:1380-1385.
7. Ahmad NR, Marks G, Mohiuddin M. High-dose preoperative radiation for cancer of the rectum: impact of radiation dose on patterns of failure and survival. Int J Radiat Oncol Biol Phys. 1993;27:773-778.
8. Movsas B, Hanlon AL, Lanciano R, et al. Phase I dose escalating trial of hyperfractionated preoperative chemoradiation for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys. 1998;42:43-50.
9. Das IJ, Lanciano RM, Movsas B, et al. Efficacy of a belly board device with CT simulation in reducing small bowel volume within irradiation fields. Int J Radiat Oncol Biol Phys. 1997;39:67-76.
10. Kaplan E, Meier P. Nonparametric estimation for incomplete observation. J Am Stat Assoc. 1958;53:457-481.
11. Suwinski R, Taylor J, Withers H. Rapid growth of microscopic rectal cancer as a determinant of response to preoperative radiation therapy. Int J Radiat Oncol Biol Phys. 1998;42:943-951.
12. Stockholm Rectal Cancer Study Group. Preoperative short-term radiation therapy in operable rectal carcinoma: a prospective randomized trial. Cancer. 1990;66:49-55.
13. Coucke PA, Sartorelli B, Cuttat JF, et al. The rationale to switch from postoperative hyperfractionated accelerated radiotherapy to preoperative hyperfractionated accelerated radiotherapy in rectal cancer. Int J Radiat Oncol Biol Phys. 1995;32:181-188.
14. Sadahiro S, Suzuki T, Ishikawa K, et al. Preoperative radio/chemoradiotherapy in combination with intraoperative radiotherapy for T3-4Nx rectal cancer. Eur J Surg Oncol. 2004;30:750-758.
15. Willett CG, Shellito PC, Tepper JE, et al. Intraoperative electron beam radiation therapy for recurrent locally advanced rectal or rectosigmoid carcinoma. Cancer. 1991;67:1504-1508.
16. Gerard JP, Chapet O, Nemoz C, et al. Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy: The Lyon R96-02 Randomized Trial. J Clin Oncol. 2004;22:2404-2409.
17. Minsky BD, Cohen AM, Enker WE, et al. Preoperative 5-FU, low-dose leucovorin, and radiation therapy for locally advanced, and unresectable rectal cancer. Int J Radiat Oncol Biol Phys. 1997;37:289-295.
18. Janjan NA, Crane CH, Feig B, et al. Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys. 2000;47:713-718.
19. Koutcher JA, Alfieri AA, Thaler H, et al. Radiation enhancement by biochemical modulation and 5-fluorouracil. Int J Radiat Oncol Biol Phys. 1997;39:1145-1152.
20. Landry JC, Koretz MJ, Wood WC, et al. Preoperative irradiation and fluorouracil chemotherapy for locally advanced rectosigmoid carcinoma: phase I-II study. Radiology. 1993;188:423-426.
21. Mohiuddin M, Regine WF, John WJ, et al. Preoperative chemoradiation in fixed distal rectal cancer: dose time factors for pathological complete response. Int J Radiat Oncol Biol Phys. 2000;46:883-888.
22. Dunst J, Reese T, Sutter T, et al. Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer. J Clin Oncol. 2002;20:3983-3991.
23. Hoff P, Janjan NA, Saad ED, et al. Phase I study of preoperative oral uracil and tegafur plus leucovorin and radiation therapy in rectal cancer. J Clin Oncol. 2000;18:3529-3534.
24. Hoff P, Royce M, Medgyesy D, et al. Oral fluoropyrimidines. Semin Oncol. 1999;26:640-646.
25. Kim JS, Cho MJ, Song KS, et al. Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys. 2002;54:403-408.
26. Lewis N, Meropol N. Development of new agents for the treatment of advanced colorectal cancer. Clin Colorectal Cancer. 2003;3:154-164.
27. Gerard JP, Chapet O, Nemoz C, et al. Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: the Lyon R0-04 phase II trial. J Clin Oncol. 2003;21:1119-1124.
28. Mehta VK, Cho C, Ford JM, et al. Phase II trial of preoperative 3D conformal radiotherapy, protracted venous infusion 5-fluorouracil, and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancer. Int J Radiat Oncol Biol Phys. 2003;55:132-137.
29. Sanfilippo NJ, Crane CH, Skibber J, et al. T4 rectal cancer treated with preoperative chemoradiation to the posterior pelvis followed by multivisceral resection: patterns of failure and limitations of treatment. Int J Radiat Oncol Biol Phys. 2001;51:176-183.
30. Rau B, Sturm I, Lage H, et al. Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. J Clin Oncol. 2003;21.
31. Giralt J, ErasoA, Armengol M, et al. Epidermal growth factor receptor is a predictor of tumor response in locally advanced rectal cancer patients treated with preoperative radiotherapy. Int J Radiat Oncol Biol Phys. 2002;54:1460-1465.