Modern stereological evaluation in the aging human substantia nigra

Image Analysis and Stereology

Volumn 22, Issue 2, 2003, Pages 73-80

  Ma, Shuang Y ^a   Longo, Frank M ^a   Röyttä, Matias ^b   Collan, Yrjö ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Aging; Quantitation; Stereology; Substantia nigra

Indexed keywords

EID: 33749544741     PISSN: 15803139     EISSN: 18545165     Source Type: Journal    
DOI: 10.5566/ias.v22.p73-80     Document Type: Review

References (52)

1. Abercrombie M (1946). Estimation of nucleus population from microtome sections. Anat Rec 94:239-47.
2. Braendgaard H, Evans SM, Howard CV, Gundersen HJG (1990). The total number of neurons in the human neocortex unbiasedly estimated using optical disectors. J Microsc 157:285-304.
3. Braendgaard H, Gundersen HJG (1986). The impact of recent stereological advances on quantitative studies of the nervous system. J Neuroscience Methods 18:39-78.
4. Cavalieri B (1966). Geometria degli indivisibili. Torino: Unione Tipografico, Editrice, pp. 1-543.
5. Chen EY, Kallwitz E, Leff SE, Cochran FJ, Mufson EJ, Kordower JH (2000). Age-related decreas in GTP-cychlohydrolase-I immunoreactive neurons in the money and human substantia nigra. J Comp Neurol 426(4):534-48.
6. Coggeshall RE (1992). A consideration of neural counting methods. Trends Neurosci 15:9-13.
7. Collan Y (1991). Quantitative histopathology of soft tissue clarifications. Proc Finn Dent Soc 87:643-50.
8. Collan Y, Aalto ML, Kosma VM (1984). Stereology and morphometry in pathology. Kuopio: Kuopio University Press, 1-270.
9. Collan Y, Oja E, Whimster W (1983). Mathematical background to stereology and morphometry for diagnostic pathologists. Acta Stereol 2:214-38.
10. Collan Y, Ma SY, Röyttä M, Rinne JO, Rinne UK (1992). Experience on the use of the disector principle in neuropathology. Acta Stereol 11(1):52-62.
11. Cruz-Orive LM, Weibel ER (1990). Recent stereological methods for cell biology: a brief survey. Am J Physiol 258 (Lung Cell Mol Physiol 2):L148-56.
12. Dowd G, Counia U, Ma SY, Kehr Jan Bacon A, Allen S, Holmes F, Wang FH, Mufson EJ, Davies C, Dawson G, Wynick D (2000). Targeted disruption of the galanin gene reduces the number of basal forebrain cholinergic neurons and impairs learning and longterm potential in an age-dependent manner. Proc Natl Acad Sci 97(21):11569-74.
13. Dorph-Petersen KA, Nyengaard JR, Gundersen HJ (2001). Tissue shrinkage and unbiased stereological estimation of particle number and size. J Microsc 204(3):232-46.
14. Fearnley JM, Lees AJ (1991). Ageing and Parkinson's disease: Substantia nigra regional selectivity. Brain 114:2283-301.
15. German DC, Manaye K, Smith WK, Woodward DJ, Saper CB (1989). Midbrain dopaminergic cell loss in Parkinson's disease: computer visualization. Ann Neurol 26:507-14.
16. Guillery RW and Herrup R (1997). Quantification without poinfication: choosing a method for counting objects in sectioned tissue. J Comp Neurol 386:2-7
17. Gundersen HJ (1978). Estimators of the number of objects per area unbiased by edge effects. Microsc Acta 81(2):107-17.
18. Gundersen HJ, Osterby R (1981). Optimizing sampling efficiency of stereological studies in biology: or' do more less well! J Microsc 121(1):65-73.
19. Gundersen HJG (1986). Stereology of arbitrary particles: A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc 143:3-45.
20. Gundersen HJ, Jensen EB (1987). The efficiency of systematic sampling in stereology and its prediction. J Microsc 147(3):229-63.
21. Gundersen HJG, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB, Vesterby A, West MJ (1988). The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96:857-81.
22. Gundersen HJG, Jensen EB (1987). The efficiency of systematic sampling in stereology and its prediction. J Microsc 147:229-63.
23. Hirai S (1968). Ageing of the substantia nigra. Adv Neurol Sci 12845-9.
24. Long JM, Mouton PR, Jucker M, Ingram DK (1999). What counts in brain aging? Design-based stereological analysis of cell number. J Gerontol A Biol Sci Med Sci 54A(10):B401-17.
25. Mann DMA, Yates PO, Marcyniuk B (1984). Monoaminergic neurotransmitter systems in presenile Alzheimer's disease and in senile dementia of Alzheimer type. Clin Neuropathol 3:199-205.
26. Mann DMA, Yates PO (1982). Pathogenesis of Parkinson's disease. Arch Neurol 39:545-9.
27. McRitchie DA, Halliday GM, Pamphlett R (1996). Diagnostic evaluation of the substantia nigra. Neuropathol Appl Neurobiol 22:228-32.
28. Ma SY (1997). The substantia nigra in Parkinson's disease: a morphological study on neuronal changes. Academical thesis, University of Turku, Finland.
29. Ma SY, Röyttä M, Rinne JO, Collan Y, Rinne UK (1995a). Single section and disector counts in evaluating neuronal loss in the substantia nigra in patients with Parkinson's disease. Neuropathol Appl Neurobiol 21:341-3.
30. Ma SY, Röyttä M, Rinne JO, Collan Y, Rinne UK (1995b). Cell counts in the substantia nigra: A comparison of single section count and disector counts in patients with Parkinson's disease and in normal controls. Neuropathol Appl Neurobiol 21(1):10-17.
31. Ma SY, Rinne JO, Röyttä M, Collan Y, Rinne UK (1997). Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts. J Neurol Sci 15:83-7.
32. Ma SY, Rinne JO, Collan Y, Röyttä M, Rinne UK (1996). A quantitative morphometrical study of the neurodegeneration in patients with Parkinson's disease. J Neurol Sci 140:40-5.
33. Ma SY, Röyttä M, Collan Y, Rinne JO (1999). Unbiased morphometrical measurements show nigral neuronal loss with aging. Neuropathol Appl Neurobiol 25:394-9.
34. Ma SY, Jaffar S, Kordower JH, Ciliax JJ, Cochran E, Mash DC, Mufson EJ (1999). Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra. J Comp Neurol 409:25-37.
35. Mayhew TM (1992). A review of recent advances in stereology for quantifying neural structure. J Neurocytol 21:313-28.
36. McGeer PL, McGeer EG, Suzuki JS (1977). Aging and extrapyramidal function. Arch Neurol 34: 33-5.
37. Olszewski J and Baxter D (1964). Cytoarchitechitecture of the human brain stem. Basel: Karger, pp. 131.
38. Pakkenberg B, Gundersen HJG (1988). Total number of neurons and glial cells in human brain nuclei estimated by the disector and the fractionator. J Microsc 150:1-20.
39. Pakkenberg B, Moller A, Gundersen HJG, Dam AM, Pakkenberg H (1991). The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. J Neurol Neurosurg Psychiat 54:30-3.
40. Park JJ, Tang Y, Lopez I, Ishiyama A (2001). Age-related change in the number of neurons in the human vestibular ganglion. J Comp Neurol 19:431(4):437-43.
41. Perl DP, Good PF, Bussiere T, Morrison JH, Erwin JM, Hof PR (2000). Practical approaches to stereologyv in the setting of aging-and disease-related brain banks. J Chem Neuroanat 20(1):7-19.
42. Schmitz C, Hof PR (2000). Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach. J Chem Neuroanat 20(1):93-114
43. Sender T, Ma SY, Jaffar S, Kordower JH, Mufson EJ (2000). Total trkA neuronal loss in the nucleus basalis in Down's syndrome: an unbiased stereological count. J Neurochem 74:1185-96.
44. Steiner RA, Hohmann JG, Holmes A, Cadd G, Jureus A, Clifton DK, Luo Mulon, Gustshall M, Ma SY, Mufson EJ, Crawley JN (2001). Memory deficits in mice overexpressing galanin. Proc Natl Acad Sci USA 27:98(7):4184-9.
45. Sterio DC (1984). The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134:127-36.
46. van Domburg PHMF, ten Donkelaar HJ (1992). The human substantia nigra and ventral tegmental area: A neuroanatomical study with notes on aging and aging disease. Adv Anat Embryol Cell Biol 121:32-69.
47. Weibel ER (1979). Stereological methods. Practical methods for biological morphometry. London: Academic Press, vol. 1, 1-415.
48. Williams RW, Pakic P (1988). Three-Dimensional counting: an accurate and direct method to estimate numbers of cells in sectioned material. J Comp Neurol 278:344-52.
49. West MJ (1993a). Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 14:287-93.
50. West MJ (1993b). New stereological methods for counting neurons. Neurobiol Aging 14:275-85.
51. Tang Y (1999). A stereological study of neuronal connections (myelinated fibers of white matter and synapses of neocortex) in the human brain. Academical thesis, University of Aarhus, Denmark.
52. Tang Y, Jens R, Nyengaard, Didima MG, De Groot, Gundersen HG (2001). Total regional and global number of synapses in the human brain neocortex. Synapse 41:258-73.