Independent contributions of neural and "higher-order" deficits to symptoms in Alzheimer's disease: A latent variable modeling approach

Alzheimer's and Dementia

Volumn 2, Issue 4, 2006, Pages 303-313

  Tractenberg, Rochelle E ^a   Aisen, Paul S ^a   Weiner, Myron F ^b   Cummings, Jeffrey L ^c   Hancock, Gregory R ^d  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

Activities of daily living; Behavior disorders; Cognition disorders; Data interpretation; Factor analysis; Geriatric assessment; Statistical; Statistics

Indexed keywords

NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PREDNISONE; ROFECOXIB;

AGED; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BEHAVIOR DISORDER; CLINICAL FEATURE; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FACTORIAL ANALYSIS; FEMALE; HUMAN; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL;

EID: 33749526850     PISSN: 15525260     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jalz.2006.08.001     Document Type: Article

References (35)

1. Berchtold N.C., and Cotman C.W. Evolution in the conceptualization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s. Neurobiol Aging 19 3 (1998) 173-189
2. Devanand D.P., Jacobs D.M., Tang M.-X., Del C.-C.C., and Sano M. The course of psychopathologic features in mild to moderate Alzheimer disease. Arch Gen Psychiatry 54 (1997) 257-263
3. th edition. (2000), American Psychiatric Publishing, Arlington, VA
4. Mohs R.C., Schmeidler J., and Aryan M. Longitudinal studies of cognitive, functional and behavioural change in patients with Alzheimer's disease. Stat Med 19 (2000) 1401-1409
5. Haxby J.V., Raffaele K., Gillette J., Schaprio M.B., and Rapoport S.I. Individual trajectories of cognitive decline in patients with dementia of the Alzheimer type. J Clin Exp Neuropsychol 14 4 (1992) 575-592
6. Ashford J.W., Shan M., Butler S., Rajasekar A., and Schmitt F.A. Temporal quantification of Alzheimer's disease severity: 'Time Index' model. Dementia 6 (1995) 269-280
7. Rasmusson D.X., Carson K.A., Brookmeyer R., Kawas C., and Brandt J. Predicting rate of cognitive decline in probable Alzheimer's disease. Brain Cognition 31 (1996) 133-147
8. Stern Y., Liu X., Albert M., Brandt J., Jacobs D.M., et al. Application of a growth curve approach to modeling the progression of Alzheimer's disease. J Gerontol Med Sci 51A 4 (1996) M179-M184
9. Hasselmo M.E. A computational model of the progression of Alzheimer's disease. MD Computing 14 3 (1997) 181-191
10. Francis D.J., Fletcher J.M., Steubing K.K., Davidson K.C., and Thompson N.M. Analysis of change: modeling individual growth. J Consult Clin Psychol 59 1 (1991) 27-37
11. Cheng C.-L., and Van N.J.W. Statistical regression with measurement error (1999), Oxford University Press/Arnold, New York
12. Cummings J.L. Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurobiological basis. Neurobiol Aging 21 (2000) 845-861
13. Buckner R.L. Three principles for cognitive aging research: multiple causes and sequelae, variance in expression and response, and the need for integrative theory. In: R Cabeza L., Nyberg L., and D P. (Eds). Cognitive neuroscience of aging: linking cognitive and cerebral aging (2001), Oxford University Press, New York 267-285
14. Howieson D.B., Camicioli R., Quinn J., Silbert L.C., Care B., Moore M.M., et al. Natural history of cognitive decline in the old. Neurology 60 (2003) 1489-1494
15. Stern R.G., Mohs R.C., Davidson M., Scheidler J., et al. A longitudinal study of Alzheimer's disease: measurement, rate and predictors of cognitive deterioration. Am J Psychiatry 151 (1994) 390-396
16. Yesavage J.A., and Brooks J.O. On the importance of longitudinal research in Alzheimer's disease. J Am Geriatr Soc 39 (1991) 942-944
17. Tractenberg R.E., Weiner M.F., Cummings J.L., and Thal L.J. Independence of changes in behavior from changes in cognition and function in persons with Alzheimer's disease: a factor-analytic approach. J Neuropsychiatry Clin Neurosci 17 1 (2005) 51-60
18. Tractenberg R.E., Weiner M.F., Patterson M.B., Schneider L., and Thal L.J. Emergent psychopathology in Alzheimer's disease patients over 12 months associated with functional, not cognitive, changes. J Geriatric Psychiatry Neurol 15 2 (2002) 110-117
19. nd edition. (2005), Guilford Press, New York
20. Thal L.J. Development of the Alzheimer's Disease Cooperative Study. Int J Geriatr Psychopharmacol 1 (1997) 6-9
21. Aisen P.S., Davis K.L., Berg J.D., Schafer K., Campbell K., Thomas R.G., et al. A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study. Neurology 54 3 (2000) 88-593
22. McKhann G., Drachman D., Folstein M., et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34 (1984) 939-944
23. Aisen P.S., Schafer K.A., Grundman M., Pfeiffer E., Sano M., Davis K.L., et al. Alzheimer's Disease Cooperative Study. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA 289 21 (2003) 2819-2826
24. Mohs R.C., Rosen W.G., and Davis K.L. The Alzheimer's Disease Assessment Scale (ADAS): An instrument for assessing treatment efficacy. Psychopharmacol Bull 18 (1983) 448-450
25. Rosen W.G., Mohs R.C., and Davis K.L. A new rating scale for Alzheimer's disease. Am J Psychiatry 41 (1984) 1356-1364
26. Hughes C.P., Berg L., Danziger W.L., Coben L.A., and Martin R.L. A new clinical scale for the staging of dementia. Br J Psychiatry 140 (1982) 566-572
27. Folstein M., Folstein S., and McHugh P. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12 (1975) 189-198
28. Stern Y., Albert S.M., Sano M., et al. Assessing patient dependence in Alzheimer's disease. J Gerontol 49 5 (1994) M216-M222
29. Galasko D., Bennett D., Sano M., Ernesto C., Thomas R., Grundman M., et al. An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 11 Suppl 2 (1997) S33-S39
30. Overall J.E., and Gorham D.R. Brief Psychiatric Rating Scale. Psychol Rep 10 (1962) 799-812
31. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 23 (1960) 56-62
32. Cummings J.L., Mega M., Gray K., Rosenberg-Thompson S., Carusi D.A., and Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in Dementia. Neurology 44 (1994) 2308-2314
33. Bentler P.M., and Wu E. EQS structural equations program manual (1995), Multivariate Software Inc, Encino, CA
34. Loehlin J.C. Latent variable models: An introduction to factor, path, and structural equation analysis, 4E (2004), Lawrence Earlbaum Associates, Mahwah, NJ
35. DeKosky S.T., and Scheff S.W. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 27 5 (1990) 457-464