A Computational Model of the Progression of Alzheimer's Disease

M.D. Computing

Volumn 14, Issue 3, 1997, Pages 181-191

  Hasselmo, Michael E ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; DISEASE COURSE; HIPPOCAMPUS; HUMAN; LEARNING; MEMORY; PATHOLOGY; PATHOPHYSIOLOGY; SYNAPTIC TRANSMISSION;

ALZHEIMER DISEASE; COMPUTER SIMULATION; DISEASE PROGRESSION; HIPPOCAMPUS; HUMANS; LEARNING; MEMORY; MODELS, NEUROLOGICAL; SYNAPTIC TRANSMISSION;

EID: 0031134367     PISSN: 07246811     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Selkoe DJ. Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci 1993; 16: 403-9.
2. Morris RG, Kopelman MD. The memory deficits in Alzheimer-type dementia: a review. Q J Exper Psychol 1986; 38A: 575-602.
3. Arriagada PV, Marzloff BA, Hyman BT. The distribution of Alzheimer type pathological changes in non-demented elderly individuals matches the pattern in Alzheimer's disease. Neurology 1992; 42: 1681-8.
4. Hyman BT, Van Hoesen GW, Damasio AR. Memory-related neural systems in Alzheimer's disease: an anatomic study. Neurology 1990; 40: 1721-30.
5. Braak J, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239-59.
6. Scoville WB, Milner B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 1957; 20: 11-21.
7. Squire LR, Zola-Morgan S. The medial temporal-lobe memory system. Science 1991; 253: 1380-6.
8. Hasselmo ME, Anderson BP, Bower JM. Cholinergic modulation of cortical associative memory function. J Neurophys 1992; 67: 1230-46.
9. Hasselmo ME. Runaway synaptic modification in models of cortex: implications for Alzheimer's disease. Neural Networks 1994; 7(1): 13-40.
10. Hasselmo ME, Barkai E. Cholinergic modulation of activity-dependent synaptic plasticity in rat piriform cortex. J Neurosci 1995; 15: 6592-604.
11. Pearson RCA, Esiri MM, Hiorns RW, Wilcock GK, Powell TPS. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer's disease. Proc Nat Acad Sci USA 1985; 82: 4531-4.
12. Davies P, Maloney AJF. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 1976; 2: 1403.
13. Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, DeLong MR. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 1982; 215: 1237-9.
14. Anderson JA. A simple neural network generating an interactive memory. Math Biosci 1972; 14: 197-220.
15. Grossberg S. Some networks that can learn, remember and reproduce any number of complicated space-time patterns. II. Studies Appl Math 1970; 49: 135-66.
16. Hopfield JJ. Neural networks and physical systems with emergent selective computational abilities. Proc Nat Acad Sci USA 1982; 79: 2554-9.
17. Hebb DO. The organization of behavior. New York: Wiley, 1949.
18. Wigstrom H, Gustafsson B, Huang Y, Abraham WC. Hippocampal long-term potentiation is induced by pairing single afferent volleys with intracellularly injected depolarizing current pulses. Acta Physiol Scand 1986; 126: 317-19.
19. Hasselmo ME, Schnell E, Barkai E. Dynamics of learning and recall at excitatory recurrent synapses and cholinergic modulation in hippocampal region CA3. J Neurosci 1995; 15: 5249-62.
20. Hasselmo ME, Bower JM. Cholinergic suppression specific to intrinsic not afferent fiber synapses in rat piriform (olfactory) cortex. J Neurophys 1992; 67: 1222-9.
21. Hasselmo ME, Schnell E. Laminar selectivity of the cholinergic suppression of synaptic transmission in rat hippocampal region CA1: computational modeling and brain slice physiology. J Neurosci 1994; 14: 3898-914.
22. Barkai E, Hasselmo ME. Modulation of the input/output function of rat piriform cortex pyramidal cells. J Neurophys 1994; 72: 644-58.
23. Horn D, Ruppin E, Usher M, Herrmann M. Neural network modeling of memory deterioration in Alzheimer's disease. Neural Comp 1993; 5: 736-49.
24. Herrmann M, Ruppin E, Usher M. A neural model of the dynamic activation of memory. Biol Cybern 1993; 68: 455-63.
25. Hansen LA, DeTeresa R, Davies P, Terry RD. Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's disease. Neurology 1988; 38: 48-54.
26. Kopelman MD. Rates of forgetting in Alzheimer-type dementia and Korsakoff's syndrome. Neuropsychologia 1985; 23: 623-38.
27. Seltzer B, Sherwin I. A comparison of clinical features in early- and late-onset primary degenerative dementia: one entity or two? Arch Neurol 1983; 40: 143-6.
28. Huff FJ, Growdown JH, Corkin S, Rosen TJ. Age at onset and rate of progression of Alzheimer's disease. J Am Geriat Soc 1987; 35: 27-30.
29. Katzman R. Alzheimer's disease. N Engl J Med 1986; 314: 964-73.
30. McNaughton BL, Morris RGM. Hippocampal synaptic enhancement and information storage within a distributed memory system. Trends Neurosci 1987; 10: 408-15.
31. Kahle JS, Cotman CW. Carbachol depresses the synaptic responses in the medial but not the lateral perforant path. Brain Res 1989; 482: 159-63.
32. Wilson MA, McNaughton BL. Reactivation of hippocampal ensemble memories during sleep. Science 1994; 265: 676-9.
33. Hasselmo ME, Schnell E, Berke J, Barkai E. A model of the hippocampus combining self-organization and associative memory function. In: Touretzky D, Mozer M, Leen T, eds. Advances in neural information processing systems. Vol 7. Cambridge, Mass: MIT Press, 1995.
34. Hasselmo ME, Wyble BP, Wallenstein GV. Encoding and retrieval of episodic memories: role of cholinergic and GABAergic modulation in the hippocampus. Hippocampus 1996; 6: 693-708.
35. Lund JS. Anatomical organization of macaque monkey striate visual cortex. Ann Rev Neurosci 1988; 11: 253-88.
36. Esiri MM, Pearson RCA, Powell TPS. Cortex of the primary auditory area in Alzheimer's disease. Brain Res 1986; 366: 385-7.
37. Rapp PR, Amaral DG. Individual differences in the cognitive and neurobiological consequences of normal aging. Trends Neurosci 1992; 15: 340-5.
38. Hasselmo ME. Neuromodulation and cortical function: modeling the physiological basis of behavior. Behav Brain Res 1995; 67: 1-27.
39. Geddes JW, Monaghan DT, Cotman CW, Loh IT, Kim RC, Chui HC. Plasticity of hippocampal circuitry in Alzheimer's disease. Science 1985; 230: 1179-81.
40. Hyman BT, Van Hoesen GW, Kromer LJ, Damasio AR. Perforant pathway changes and the memory impairment of Alzheimer's disease. Ann Neurol 1986; 20: 472-81.
41. Milward EA, Papadopolous R, Fuller SJ, Moir RD, Small D. The amyloid protein-precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 1992; 9: 129-37.
42. Grundkeiqbal I, Iqbal K, Tung YC, Quinlan M, Wisneiwski HM, Binder LI. Abnormal phosphorylation of the microtubule associated protein tau in Alzheimer cytoskeletal pathology. Proc Nat Acad Sci USA 1986; 83: 4913-17.
43. Kosik KS, Caceres A. Tau-protein and the establishment of an axonal morphology. J Cell Sci 1991; S15: 69-74.
44. Butters N, Granholm E, Salmon DP, Grant I, Wolfe J. Episodic and semantic memory: a comparison of amnesic and demented patients. J Clin Exper Neuropsychol 1987; 9: 479-97.
45. Fuld PA, Katzman R, Davies P, Terry RD. Intrusions as a sign of Alzheimer dementia: chemical and pathological verification. Ann Neurol 1982; 11: 155-9.
46. Troster AI, Jacobs D, Butters N, Cullum CM, Salmon DP. Differentiating Alzheimer's disease from Huntington's disease with the Wechsler Memory Scale - Revised. Clin Geriat Med 1989; 5: 611-32.
47. Jacobs D, Salmon DP, Troster AI, Butters N. Intrusion errors in the figural memory of patients with Alzheimer's and Huntington's disease. Arch Clin Neuropsychol 1990; 5: 49-57.
48. Delis DC, Massman PJ, Butters N, Salmon DP, Cermak LS, Kramer JH. Profiles of demented and amnesic patients on the California Verbal Learning Test: implications for the assessment of memory disorders. Psychol Assess 1991; 3: 19-26.
49. Corkin S, Growdown JH, Nissen MJ, Huff FJ, Freed DM, Sagar HJ. Recent advances in the neuropsychological study of Alzheimer's disease. In: Wurtman RJ, Corkin S, Growdown JH. Alzheimer's disease: advances in basic research and therapies. Cambridge, Mass: Center for Brain Sciences, 1984.
50. Huff FJ, Corkin S, Growdon JH. Semantic impairment and anomia in Alzheimer's disease. Brain and Language 1986; 34: 269-78.