The human ortholog of the rodent testis-specific ABC transporter Abca17 is a ubiquitously expressed pseudogene (ABCA17P) and shares a common 5′ end with ABCA3

BMC Molecular Biology

Volumn 7, Issue , 2006, Pages

  Piehler, Armin P ^a   Wenzel, Jürgen J ^b   Olstad, Ole K ^a   Haug, Kari Bente Foss ^a   Kierulf, Peter ^a   Kaminski, Wolfgang E ^c  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A17; ABC TRANSPORTER A3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME 16P; EXON; GENE DUPLICATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN GENOME; HUMAN TISSUE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PSEUDOGENE; RNA SPLICING; RNA TRANSLATION; SEQUENCE HOMOLOGY;

ALTERNATIVE SPLICING; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 16; DNA, COMPLEMENTARY; EXONS; EXPRESSED SEQUENCE TAGS; GENE DUPLICATION; GENES, OVERLAPPING; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTATION; PROTEINS; PSEUDOGENES; RATS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; SPECIES SPECIFICITY; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC;

RODENTIA;

EID: 33749524215     PISSN: 14712199     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-7-28     Document Type: Article

References (29)

1. Higgins CF: ABC transporters: from microorganisms to man. Annu Rev Cell Biol 1992, 8:67-113.
2. Dean M: The genetics of ATP-binding cassette transporters. Methods Enzymol 2005, 400:409-429.
3. Kaminski WE, Piehler A, Wenzel JJ: ABC A-subfamily transporters: structure, function and disease. Biochim Biophys Acta 2006, 1762:510-524.
4. Ban N, Sasaki M, Sakai H, Ueda K, Inagaki N: Cloning of ABCA17, a novel rodent sperm-specific ABC (ATP-binding cassette) transporter that regulates intracellular lipid metabolism. Biochem J 2005, 389:577-585.
5. Breatnach R, Chambon P: Organization and expression of eucaryotic split genes coding for proteins. Annu Rev Biochem 1981, 50:349-383.
6. Klugbauer N, Hofmann F: Primary structure of a novel ABC transporter with a chromosomal localization on the band encoding the multidrug resistance-associated protein. FEBS Lett 1996, 391:61-65.
7. Dean M, Annilo T: Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Annu Rev Genomics Hum Genet 2005, 6:123-142.
8. Makalowska I, Lin CF, Makalowski W: Overlapping genes in vertebrate genomes. Comput Biol Chem 2005, 29:1-12.
9. Murphy WJ, Eizirik E, O'Brien SJ, Madsen O, Scally M, Douady CJ, Teeling E, Ryder OA, Stanhope MJ, de Jong WW, Springer MS: Resolution of the early placental mammal radiation using Bayesian phylogenetics. Science 2001, 294:2348-2351.
10. Shulenin S, Nogee LM, Annilo T, Wert SE, Whitsett JA, Dean M: ABCA3 gene mutations in newborns with fatal surfactant deficiency. N Engl J Med 2004, 350:1296-1303.
11. Karlin S, Chen C, Gentles AJ, Cleary M: Associations between human disease genes and overlapping gene groups and multiple amino acid runs. Proc Natl Acad Sci U S A 2002, 99:17008-17013.
12. Bischof JM, Chiang AP, Scheetz TE, Stone EM, Casavant TL, Sheffield VC, Braun TA: Genome-wide identification of pseudogenes capable of disease-causing gene conversion. Hum Mutat 2006, 27:545-552.
13. Cai L, Lumsden A, Guenther UP, Neldner SA, Zach S, Knoblauch H, Ramesar R, Hohl D, Callen DF, Neldner KH, Lindpaintner K, Richards RI, Struk B: A novel Q378X mutation exists in the transmembrane transporter protein ABCC6 and its pseudogene: implications for mutation analysis in pseudoxanthoma elasticum. J Mol Med 2001, 79:536-546.
14. Zhang Z, Gerstein M: Large-scale analysis of pseudogenes in the human genome. Curr Opin Genet Dev 2004, 14:328-335.
15. Torrents D, Suyama M, Zdobnov E, Bork P: A genome-wide survey of human pseudogenes. Genome Res 2003, 13:2559-2567.
16. Zheng D, Zhang Z, Harrison PM, Karro J, Carriero N, Gerstein M: Integrated pseudogene annotation for human chromosome 22: evidence for transcription. J Mol Biol 2005, 349:27-45.
17. Hirotsune S, Yoshida N, Chen A, Garrett L, Sugiyama F, Takahashi S, Yagami K, Wynshaw-Boris A, Yoshiki A: An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Nature 2003, 423:91-96.
18. Korneev SA, Park JH, O'Shea M: Neuronal expression of neural nitric oxide synthase (nNOS) protein is suppressed by an antisense RNA transcribed from an NOS pseudogene. J Neurosci 1999, 19:7711-7720.
19. Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, Haussler D: The human genome browser at UCSC. Genome Res 2002, 12:996-1006.
20. UCSC Genome Browser 2006 [http://genome.ucsc.edu/].
21. Rognes T: ParAlign: a parallel sequence alignment algorithm for rapid and sensitive database searches. Nucleic Acids Res 2001, 29:1647-1652.
22. ParAlign 2006 [http://www.paralign.org/].
23. Takai D, Jones PA: The CpG island searcher: a new WWW resource. In Silico Biol 2003, 3:235-240.
24. CpG Island Searcher 2006 [http://www.cpgislands.com/].
25. HUSAR Bioinformatics Lab 2006 [http://genome.dkfz-heidelberg.de/].
26. Rice P, Longden I, Bleasby A: EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet 2000, 16:276-277.
27. EMBOSS 2006 [http://emboss.sourceforge.net/].
28. GENECONV: Statistical Tests for Detecting Gene Conversion 2006 [http://www.math.wustl.edu/~sawyer/geneconv/index.html].
29. Piehler A, Kaminski WE, Wenzel JJ, Langmann T, Schmitz G: Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9. Biochem Biophys Res Commun 2002, 295:408-416.