Biomimetic transfer hydrogenation of ketones with iron porphyrin catalysts

Tetrahedron Letters

Volumn 47, Issue 46, 2006, Pages 8095-8099

  Enthaler, Stephan ^a   Erre, Giulia ^a   Tse, Man Kin ^a   Junge, Kathrin ^a   Beller, Matthias ^a  

^a LEIBNIZ INSTITUT FÜR KATALYSE E V AN DER UNIVERSITÄT ROSTOCK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPANOL; ALCOHOL DERIVATIVE; HYDROGEN; KETONE DERIVATIVE; PORPHYRIN DERIVATIVE; PORPHYRIN IRON; UNCLASSIFIED DRUG;

ARTICLE; BIOMIMETICS; CATALYST; CHEMICAL REACTION; HYDROGENATION; TURNOVER TIME;

EID: 33749514368     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.09.058     Document Type: Article

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53. 12 (0.0013 mmol) and porphyrin 1a (0.0038 mmol) is dissolved in 1.0 mL 2-propanol and stirred for 16 h at 65 °C. Then a solution of sodium 2-propylate (0.19 mmol) in 0.5 mL 2-propanol is added. The solution is stirred for 5 min at 100 °C followed by the addition of 0.38 mmol acetophenone 4. After 7 h at 100 °C, the mixture is cooled to rt and filtered over a plug of silica gel. The conversion and yield were determined by GC without further purification. All synthesized alcohols are known compounds. Their characterization is done by a comparison with authentic samples.
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