Enantioselective reduction of aromatic and aliphatic ketones catalyzed by ruthenium complexes attached to β-cyclodextrin

Angewandte Chemie - International Edition

Volumn 43, Issue 48, 2004, Pages 6731-6734

  Schlatter, Alain ^a   Kundu, Mrinal K ^a   Woggon, Wolf D ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Asymmetric catalysis; Cyclodextrins; Reduction; Ruthenium; Transfer hydrogenation

Indexed keywords

CATALYSIS; COMPLEXATION; HYDROPHOBICITY; REDUCTION; RUTHENIUM; SODIUM COMPOUNDS; SOLUBILITY;

ALIPHATIC KETONES; ENANTIOSELECTIVITY; WATER-SOLUBLE CHIRALS;

KETONES;

ALIPHATIC KETONE; AROMATIC COMPOUND; BETA CYCLODEXTRIN; FORMATE SODIUM; FORMIC ACID DERIVATIVE; KETONE; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CATALYST; CRYSTAL STRUCTURE; ENANTIOSELECTIVITY; HYDROPHOBICITY; MOLECULAR RECOGNITION; OPTICAL ROTATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REDUCTION; SUPRAMOLECULAR CHEMISTRY;

BETA-CYCLODEXTRINS; CATALYSIS; CYCLODEXTRINS; KETONES; LIGANDS; MODELS, MOLECULAR; ORGANOMETALLIC COMPOUNDS; OXIDATION-REDUCTION; RUTHENIUM; STEREOISOMERISM;

EID: 10944239452     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200460102     Document Type: Article

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24. The concentrations of the catalyst (10 mol%) and formate (excess) were adjusted to give a reasonable reaction time of approximately 24 h. Decreasing the catalyst and/or formate concentration led to unsuitably long reaction times. Preliminary experiments in which Ru-O was replaced by Ru-NTos revealed a sixfold increase in the rate of the reaction, thus allowing for lower catalyst loadings; results will be reported in a subsequent publication.