Drosophila S2 cells produce multiple forms of carboxypeptidase D with different intracellular distributions

Journal of Cellular Biochemistry

Volumn 99, Issue 3, 2006, Pages 770-783

  Kalinina, Elena ^a   Fontenele Neto, Jose D ^a,b   Fricker, Lloyd D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Esc Sup de Agric de Mossoro   (Brazil)

Author keywords

Furin; Metallocarboxypeptidase; Peptide processing; Silver gene; trans Golgi network

Indexed keywords

ALBUMIN; CARBOXYPEPTIDASE D; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA; EXON; GOLGI COMPLEX; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; WESTERN BLOTTING;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; CARBOXYPEPTIDASES; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENES, REPORTER; ISOENZYMES; MICE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY;

MAMMALIA; VERTEBRATA;

EID: 33749455586     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20972     Document Type: Article

References (37)

1. Bonifacino JS, Traub LM. 2003. Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem 72:395-447.
2. Eng FJ, Novikova EG, Kuroki K, Ganem D, Fricker LD. 1998. gp180, a protein that binds duck hepatitis B virus particles, has metallocarboxypeptidase D-like enzymatic activity. J Biol Chem 273:8382-8388.
3. Eng FJ, Varlamov O, Fricker LD. 1999. Sequences within the cytoplasmic domain of gp180/carboxypeptidase D mediate localization to the trans-Golgi network. Mol Biol Cell 10:35-46.
4. Fricker LD. 2002. Carboxypeptidases E and D. In: Dalbey RE, Sigman DS, editors. The Enzymes, Vol. 23. Co- and posttranslational proteolysis of proteins. San Diego: Academic Press, pp 421-452.
5. Fricker LD. 2004a. Carboxypeptidase E. In: Barrett AJ, Rawlings ND, Woessner JF, editors. Handbook of proteolytic enzymes. San Diego: Academic Press, pp 840-844.
6. Fricker LD. 2004b. Carboxypeptidase Z. In: Barrett AJ, Rawlings ND, Woessner JF, editors. Handbook of proteolytic enzymes. San Diego: Academic Press, pp 844-846.
7. Fricker LD. 2004c. Metallocarboxypeptidase D. In: Barrett AJ, Rawlings ND, Woessner JF, editors. Handbook of proteolytic enzymes. San Diego: Academic Press, pp 848-851.
8. Fricker LD, Leiter EH. 1999. Peptides, enzymes, and obesity: New insights from a "dead" enzyme. Trends Biochem Sci 24:390-393.
9. Fricker LD, Snyder SH. 1982. Enkephalin convertase: Purification and characterization of a specific enkephalin-synthesizing Carboxypeptidase localized to adrenal chromaffin granules. Proc Natl Acad Sci USA 79:3886-3890.
10. He GP, Muise A, Li AW, Ro HS. 1995. A eukaryotic transcriptional repressor with carboxypeptidase activity. Nature 378:92-96.
11. Ishikawa T, Murakami K, Kido Y, Ohnishi S, Yazaki Y, Harada F, Kuroki K. 1998. Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. Gene 215:361-370.
12. Kalinina E, Varlamov O, Fricker LD. 2002. Analysis of the carboxypeptidase D cytoplasmic domain: Implications in intracellular trafficking. J Cell Biochem 85:101-111.
13. Kuroki K, Eng F, Ishikawa T, Turck C, Harada F, Ganem D. 1995. gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family. J Biol Chem 270:15022-15028.
14. Layne MD, Endege WO, Jain MK, Yet S, Hsieh C, Chin MT, Perrella MA, Blanar MA, Haber E, Lee M. 1998. Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. J Biol Chem 273:15654-15660.
15. Layne MD, Yet SF, Maemura K, Hsieh CM, Bernfield M, Perrella MA, Lee ME. 2001. Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein. Mol Cell Biol 21:5256-5261.
16. Lei Y, Xin X, Morgan D, Pintar JE, Fricker LD. 1999. Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2. DNA Cell Biol 18:175-185.
17. Mitra A, Song L, Fricker LD. 1994. The C-terminal region of carboxypeptidase E is involved in membrane binding and intracellular routing in AtT-20 cells. J Biol Chem 269:19876-19881.
18. Naggert JK, Fricker LD, Varlamov O, Nishina PM, Rouille Y, Steiner DF, Carroll RJ, Paigen BJ, Leiter EH. 1995. Hyperproinsulinemia in obese fat/fat mice associated with a point mutation in the carboxypeptidase E gene and reduced carboxypeptidase E activity in the pancreatic islets. Nat Genet 10:135-142.
19. Novikova EG, Eng FJ, Yan L, Qian Y, Fricker LD. 1999. Characterization of the enzymatic properties of the first and second domains of metallocarboxypeptidase D. J Biol Chem 274:28887-28892.
20. Novikova EG, Reznik SE, Varlamov O, Fricker LD. 2000. Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues. J Biol Chem 275:4865-4870.
21. Reznik SE, Fricker LD. 2001. Carboxypeptidases from A to Z: Implications in embryonic development and Wnt binding. Cell Mol Life Sci 58:1790-1804.
22. Schneider I. 1972. Cell lines derived from late embryonic stages of Drosophila melanogaster. J Embryol Exp Morphol 27:353-365.
23. Settle SHJ, Green MM, Burtis KC. 1995. The silver gene of Drosophila melanogaster encodes multiple carboxypeptidases similar to mammalian prohormone-processing enzymes. Proc Natl Acad Sci USA 92:9470-9474.
24. Sidyelyeva G, Fricker LD. 2002. Characterization of Drosophila carboxypeptidase D. J Biol Chem 277:49613-49620.
25. Skidgel RA. 1988. Basic carboxypeptidases: Regulators of peptide hormone activity. Trends Pharmacol Sci 9:299-304.
26. Skidgel RA. 2004. Carboxypeptidase M. In: Barrett AJ, Rawlings ND, Woessner JF, editors. Handbook of proteolytic enzymes. San Diego: Academic Press, pp 851-854.
27. Skidgel RA, Erdos EG. 2004. Lysine carboxypeptidase. In: Barrett AJ, Rawlings ND, Woessner JF, editors. Handbook of proteolytic enzymes. San Diego: Academic Press, pp 837-840.
28. Song L, Fricker LD. 1995. Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary. J Biol Chem 270:25007-25013.
29. Song L, Fricker LD. 1996. Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D. J Biol Chem 271:28884-28889.
30. Stanley H, Botas J, Malhotra V. 1997. The mechanism of Golgi segregation during mitosis is cell type-specific. Proc Natl Acad Sci USA 94:14467-14470.
31. Tan F, Rehli M, Krause SW, Skidgel RA. 1997. Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains. Biochem J 327:81-87.
32. Varlamov O, Fricker LD. 1998. Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells: Localization to the trans-Golgi network and recycling from the cell surface. J Cell Sci 111:877-885.
33. Varlamov O, Eng FJ, Novikova EG, Fricker LD. 1999a. Localization of metallocarboxypeptidase D in AtT-20 cells: Potential role in prohormone processing. J Biol Chem 274:14759-14767.
34. Varlamov O, Wu F, Shields D, Fricker LD. 1999b. Biosynthesis and packaging of carboxypeptidase D into nascent secretory vesicles in pituitary cell lines. J Biol Chem 274:14040-14045.
35. Varlamov O, Kalinina E, Che F, Fricker LD. 2001. Protein phosphatase 2A binds to the cytoplasmic tail of carboxypeptidase D and regulates post-TGN trafficking. J Cell Sci 114:311-322.
36. Xin X, Varlamov O, Day R, Dong W, Bridgett MM, Leiter EH, Fricker LD. 1997. Cloning and sequence analysis of cDNA encoding rat carboxypeptidase D. DNA Cell Biol 16:897-909.
37. Xin X, Day R, Dong W, Lei Y, Fricker LD. 1998. Identification of mouse CPX-2, a novel member of the metallocarboxypeptidase gene family: cDNA cloning, mRNA distribution, and protein expression and characterization. DNA Cell Biol 17:897-909.