A calorimetric method to estimate molecular mobility of amorphous solids at relatively low temperatures

Pharmaceutical Research

Volumn 23, Issue 10, 2006, Pages 2269-2276

  Mao, Chen ^a   Prasanth Chamarthy, Sai ^a   Byrn, Stephen R ^a   Pinal, Rodolfo ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Amorphous; Differential scanning calorimetry; Fictive temperature; Molecular mobility; Relaxation; Stability

Indexed keywords

ARTICLE; CALCULATION; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STABILITY; LOW TEMPERATURE; MATHEMATICAL ANALYSIS; MOLECULAR MECHANICS; PRIORITY JOURNAL; SHELF LIFE; STORAGE TEMPERATURE;

ALGORITHMS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG STABILITY; ENTROPY; NONLINEAR DYNAMICS; TEMPERATURE;

EID: 33749435820     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9071-9     Document Type: Article

References (21)

1. B. C. Hancock, S. L. Shamblin, and G. Zografi. Molecular mobility of amorphous pharmaceutical solids below their glass-transition temperatures. Pharm. Res. 12:799-806 (1995).
2. B. C. Hancock and G. Zografi. The relationship between the glass-transition temperature and the water-content of amorphous pharmaceutical solids. Pharm. Res. 11:471-477 (1994).
3. B. C. Hancock and G. Zografi. Characteristics and significance of the amorphous state in pharmaceutical systems. J. Pharm. Sci. 86:1-12 (1997).
4. P. Tong and G. Zografi. Effects of water vapor absorption on the physical and chemical stability of amorphous sodium indomethacin. Aaps Pharmscitech 5: Art. No. 26 (2004).
5. V. Andronis and G. Zografi. The molecular mobility of supercooled amorphous indomethacin as a function of temperature and relative humidity. Pharm. Res. 15:835-842 (1998).
6. B. C. Hancock and S. L. Shamblin. Molecular mobility of amorphous pharmaceuticals determined using differential scanning calorimetry. Thermochim. Acta 380:95-107 (2001).
7. S. R. Byrn, W. Xu, and A. W. Newman. Chemical reactivity in solid-state pharmaceuticals: formulation implications. Adv. Drug Deliv. Rev. 48:115-136 (2001).
8. K. Kawakami and M. J. Pikal. Calorimetric investigation of the structural relaxation of amorphous materials: evaluating validity of the methodologies. J. Pharm. Sci. 94:948-965 (2005).
9. C. Mao, S. P. Chamarthy, and R. Pinal. Time-dependence of molecular mobility during structural relaxation and its impact on organic amorphous solids: an investigation based on a calorimetric approach. Pharm. Res. 23:1906-1917 (2006).
10. S. L. Shamblin, B. C. Hancock, Y. Dupuis, and M. J. Pikal. Interpretation of relaxation time constants for amorphous pharmaceutical systems. J. Pharm. Sci. 89:417-427 (2000).
11. G. Adam and J. H. Gibbs. On temperature dependence of cooperative relaxation properties in glass-forming liquids. J. Chem. Phys. 43:139-146 (1965).
12. G. W. Scherer. Use of the Adam-Gibbs equation in the analysis of structural relaxation. J. Am. Ceram. Soc. 67:504-511 (1984).
13. I. M. Hodge. Enthalpy relaxation and recovery in amorphous materials. J. Non-Cryst. Solids 169:211-266 (1994).
14. K. J. Crowley and G. Zografi. The use of thermal methods for predicting glass-former fragility. Thermochim. Acta 380:79-93 (2001).
15. I. M. Hodge. Strong and fragile liquids - a brief critique. J. Non-Cryst. Solids 202:164-172 (1996).
16. S. L. Shamblin, X. L. Tang, L. Q. Chang, B. C. Hancock, and M. J. Pikal. Characterization of the time scales of molecular motion in pharmaceutically important glasses. J. Phys. Chem. B 103:4113-4121 (1999).
17. C. T. Moynihan, A. J. Easteal, J. Wilder, and J. Tucker. Dependence of Glass-transition temperature on heating and cooling rate. J. Phys. Chem. 78:2673-2677 (1974).
18. 1H NMR relaxation times. J. Pharm. Sci. 89:408-416 (2000).
19. D. L. Zhou, G. G. Z. Zhang, D. Law, D. J. W. Grant, and E. A. Schmitt. Physical stability of amorphous pharmaceuticals: importance of configurational thermodynamic quantities and molecular mobility. J. Pharm. Sci. 91:1863-1872 (2002).
20. J. J. M. Ramos, R. Taveira-Marques, and H. P. Diogo. Estimation of the fragility index of indomethacin by DSC using the heating and cooling rate dependency of the glass transition. J. Pharm. Sci. 93:1503-1507 (2004).
21. I. Weuts, D. Kempen, K. Six, J. Peeters, G. Verreck, M. Brewster, and G. Van den Mooter. Evaluation of different calorimetric methods to determine the glass transition temperature and molecular mobility below T-g for amorphous drugs. Int. J. Pharm.259:17-25 (2003).