Endocarditis and biofilm-associated pili of Enterococcus faecalis

Journal of Clinical Investigation

Volumn 116, Issue 10, 2006, Pages 2799-2807

  Nallapareddy, Sreedhar R ^a   Singh, Kavindra V ^a   Sillanpää, Jouko ^a,b   Garsin, Danielle A ^a   Höök, Magnus ^b   Erlandsen, Stanley L ^c   Murray, Barbara E ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISERUM; BACTERIAL PROTEIN; PROTEIN EBPA; PROTEIN EBPC; SORTASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM PILUS; BIOFILM; ELECTRON MICROSCOPY; ENDOCARDITIS; ENTEROCOCCUS FAECALIS; GENE LOCUS; IN VIVO STUDY; NONHUMAN; OPERON; PRIORITY JOURNAL;

AMINOACYLTRANSFERASES; ANIMALS; AORTA; BACTERIAL ADHESION; BACTERIAL PROTEINS; BIOFILMS; CYSTEINE ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; ENDOCARDITIS, BACTERIAL; ENTEROCOCCUS FAECALIS; FIMBRIAE PROTEINS; FIMBRIAE, BACTERIAL; GENE DELETION; GENE ORDER; GRAM-POSITIVE BACTERIAL INFECTIONS; KIDNEY; MALE; MICROSCOPY, ELECTRON; MUTAGENESIS, INSERTIONAL; MUTATION; OPERON; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33749430001     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI29021     Document Type: Article

References (47)

1. Murray, B.E., and Weinstock, G.M. 1999. Enterococci: new aspects of an old organism. Proc. Assoc. Am. Physicians. 111:328-334.
2. Richards, M.J., Edwards, J.R., Culver, D.H., and Gaynes, R.P. 2000. Nosocomial infections in combined medical-surgical intensive care units in the United States. Infect. Control Hosp. Epidemiol. 21:510-515.
3. Megran, D.W. 1992. Enterococcal endocarditis. Clin. Infect. Dis. 15:63-71.
4. Koch, S., Hufnagel, M., Theilacker, C., and Huebner, J. 2004. Enterococcal infections: host response, therapeutic, and prophylactic possibilities. Vaccine. 22:822-830.
5. Rivas, J.M., Speziale, P., Patti, J.M., and Hook, M. 2004. MSCRAMM-targeted vaccines and immunotherapy for staphylococcal infection. Curr. Opin. Drug Discov. Devel. 7:223-227.
6. Sillanpaa, J., Xu, Y., Nallapareddy, S.R., Murray, B.E., and Hook, M. 2004. A family of putative MSCRAMMs from Enterococcus faecalis. Microbiology. 150:2069-2078.
7. Paulsen, I.T., et al. 2003. Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science. 299:2071-2074.
8. Deivanayagam, C.C., et al. 2002. A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A. EMBO J. 21:6660-6672.
9. O'Toole, G., Kaplan, H.B., and Kolter, R. 2000. Biofilm formation as microbial development. Annu. Rev. Microbiol. 54:49-79.
10. Carniol, K., and Gilmore, M.S. 2004. Signal transduction, quorum-sensing, and extracellular protease activity in Enterococcus faecalis biofilm formation. J. Bacteriol. 186:8161-8163.
11. Donlan, R.M., and Costerton, J.W. 2002. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin. Microbiol. Rev. 15:167-193.
12. Mohamed, J.A., Huang, W., Nallapareddy, S.R., Teng, F., and Murray, B.E. 2004. Influence of origin of isolates, especially endocarditis isolates, and various genes on biofilm formation by Enterococcus faecalis. Infect. Immun. 72:3658-3663.
13. Toledo-Arana, A., et al. 2001. The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation. Appl. Environ. Microbiol. 67:4538-4545.
14. Hancock, L.E., and Perego, M. 2004. The Enterococcus faecalis fsr two-component system controls biofilm development through production of gelatinase. J. Bacteriol. 186:5629-5639.
15. Hufnagel, M., Koch, S., Creti, R., Baldassarri, L., and Huebner, J. 2004. A putative sugar-binding transcriptional regulator in a novel gene locus in Enterococcus faecalis contributes to production of biofilm and prolonged bacteremia in mice. J. Infect. Dis. 189:420-430.
16. Kristich, C.J., Li, Y.H., Cvitkovitch, D.G., and Dunny, G.M. 2004. Esp-independent biofilm formation by Enterococcus faecalis. J. Bacteriol. 186:154-163.
17. Tendolkar, P.M., Baghdayan, A.S., and Shankar, N. 2006. Putative surface proteins encoded within a novel transferable locus confer a high-biofilm phenotype to Enterococcus faecalis. J. Bacteriol. 188:2063-2072.
18. Wu, H., and Fives-Taylor, P.M. 2001. Molecular strategies for fimbrial expression and assembly. Crit. Rev. Oral Biol. Med. 12:101-115.
19. Ton-That, H., Marraffini, L.A., and Schneewind, O. 2004. Sortases and pilin elements involved in pilus assembly of Corynebacterium diphtheriae. Mol. Microbiol. 53:251-261.
20. Mora, M., et al. 2005. Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens. Proc. Natl. Acad. Sci. U. S. A. 102:15641-15646.
21. Lauer, P., et al. 2005. Genome analysis reveals pili in Group B Streptococcus. Science. 309:105.
22. Barocchi, M.A., et al. 2006. A pneumococcal pilus influences virulence and host inflammatory responses. Proc. Natl. Acad. Sci. U. S. A. 103:2857-2862.
23. Mazmanian, S.K., Liu, G., Ton-That, H., and Schneewind, O. 1999. Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Science. 285:760-763.
24. Ton-That, H., and Schneewind, O. 2003. Assembly of pili on the surface of Corynebacterium diphtheriae. Mol. Microbiol. 50:1429-1438.
25. Handley, P.S., and Jacob, A.E. 1981. Some structural and physiological properties of fimbriae of Streptococcus faecalis. J. Gen. Microbiol. 127:289-293.
26. Foster, T.J., and Hook, M. 1998. Surface protein adhesins of Staphylococcus aureus. Trends Microbiol. 6:484-488.
27. Dunne, W.M., Jr. 2002. Bacterial adhesion: seen any good biofilms lately? Clin. Microbiol. Rev. 15:155-166.
28. Bryan, E.M., Bae, T., Kleerebezem, M., and Dunny, G.M. 2000. Improved vectors for nisin-controlled expression in gram-positive bacteria. Plasmid. 44:183-190.
29. Xu, Y., Murray, B.E., and Weinstock, G.M. 1998. A cluster of genes involved in polysaccharide biosynthesis from Enterococcus faecalis OG1RF. Infect. Immun. 66:4313-4323.
30. Winberg, J., et al. 1995. The PapG-adhesin at the tip of P-fimbriae provides Escherichia coli with a competitive edge in experimental bladder infections of cynomolgus monkeys. J. Exp. Med. 182:1695-1702.
31. Hienz, S.A., Schennings, T., Heimdahl, A., and Flock, J.I. 1996. Collagen binding of Staphylococcus aureus is a virulence factor in experimental endocarditis. J. Infect. Dis. 174:83-88.
32. Nannini, E.C., Teng, F., Singh, K.V., and Murray, B.E. 2005. Decreased virulence of a gls24 mutant of Enterococcus faecalis OG1RF in an experimental endocarditis model. Infect. Immun. 73:7772-7774.
33. Moreillon, P., Que, Y.A., and Bayer, A.S. 2002. Pathogenesis of streptococcal and staphylococcal endocarditis. Infect. Dis. Clin. North Am. 16:297-318.
34. Gilmore, M.S., Coburn, P.S., Nallapareddy, S.R., and Murray, B.E. 2002. Enterococcal virulence. In The enterococci: pathogenesis, molecular biology, antibiotic resistance and infection control. M.S. Gilmore, et al., editors. American Society for Microbiology. Washington, DC, USA. 301-354.
35. Xiao, J., Hook, M., Weinstock, G.M., and Murray, B.E. 1998. Conditional adherence of Enterococcus faecalis to extracellular matrix proteins. FEMS Immunol. Med. Microbiol. 21:287-295.
36. Murray, B.E., et al. 1993. Generation of restriction map of Enterococcus faecalis OG1 and investigation of growth requirements and regions encoding biosynthetic function. J. Bacteriol. 175:5216-5223.
37. Nallapareddy, S.R., Qin, X., Weinstock, G.M., Hook, M., and Murray, B.E. 2000. Enterococcus faecalis adhesin, ace, mediates attachment to extracellular matrix proteins collagen type IV and laminin as well as collagen type I. Infect. Immun. 68:5218-5224.
38. Singh, K.V., Nallapareddy, S.R., Nannini, E.C., and Murray, B.E. 2005. Fsr-independent production of protease(s) may explain the lack of attenuation of an Enterococcus faecalis fsr mutant versus a gelE-sprE mutant in induction of endocarditis. Infect. Immun. 73:4888-4894.
39. Singh, K.V., Qin, X., Weinstock, G.M., and Murray, B.E. 1998. Generation and testing of mutants of Enterococcus faecalis in a mouse peritonitis model. J. Infect. Dis. 178:1416-1420.
40. Parsek, M.R., and Singh, P.K. 2003. Bacterial biofilms: an emerging link to disease pathogenesis. Annu. Rev. Microbiol. 57:677-701.
41. Mohamed, J.A., and Murray, B.E. 2005. Lack of correlation of gelatinase production and biofilm formation in a large collection of Enterococcus faecalis isolates. J. Clin. Microbiol. 43:5405-5407.
42. Qin, X., et al. 1998. Targeted mutagenesis of enterococcal genes. Methods Cell Sci. 20:21-33.
43. Murray, B.E., Singh, K.V., Heath, J.D., Sharma, B.R., and Weinstock, G.M. 1990. Comparison of genomic DNAs of different enterococcal isolates using restriction endonucleases with infrequent recognition sites. J. Clin. Microbiol. 28:2059-2063.
44. Li, X., Weinstock, G.M., and Murray, B.E. 1995. Generation of auxotrophic mutants of Enterococcus faecalis. J. Bacteriol. 177:6866-6873.
45. Sambrook, J., Fritsch, E.F., and Maniatis, J. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, New York, USA. 1659 pp.
46. Nallapareddy, S.R., Singh, K.V., Duh, R.W., Weinstock, G.M., and Murray, B.E. 2000. Diversity of ace, a gene encoding a microbial surface component recognizing adhesive matrix molecules, from different strains of Enterococcus faecalis and evidence for production of ace during human infections. Infect. Immun. 68:5210-5217.
47. Beuzon, C.R., and Holden, D.W. 2001. Use of mixed infections with Salmonella strains to study virulence genes and their interactions in vivo. Microbes Infect. 3:1345-1352.