Activity of Ginkgo biloba extract and quercetin on thrombomodulin expression and tissue-type plasminogen activator secretion by human umbilical vein endothelial cells

Biomedical and Environmental Sciences

Volumn 19, Issue 4, 2006, Pages 249-253

  Lan, Wen Jun ^a   Zheng, Xiao Xiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Ginkgo biloba extract; Quercetin; Thrombomodulin; Tissue type plasminogen activator

Indexed keywords

PLANT EXTRACT; QUERCETIN; THROMBOMODULIN; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; CHEMISTRY; CIRCULATION; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; FLOW CYTOMETRY; GINKGO BILOBA; HUMAN; METABOLISM; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

BLOOD CIRCULATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; GINKGO BILOBA; HUMANS; PLANT EXTRACTS; QUERCETIN; THROMBOMODULIN; TISSUE PLASMINOGEN ACTIVATOR; UMBILICAL VEINS;

GINKGO BILOBA;

EID: 33749408132     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Mahady G B (2002). Ginkgo biloba for the prevention and treatment of cardiovascular disease: a review of the literature. J Cardiovasc Nursing 16, 21-32.
2. Dittman W A, Majerus P W (1990). Structure and function of thrombomodulin: a natural anticoagulant. Blood 75, 329-336.
3. Lentz S R, Chen Y, Sadler J E (1993). Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin. J Biol Chem 268, 15312-15317.
4. Wu K K, Matijevic-Aleksic N (2000). Thrombomodulin: a linker of coagulation and fibrinolysis and predictor of risk of arterial thrombosis. ANN Med 32 (Suppl), 73-77.
5. Waugh J M, Yuksel E, Li J, et al. (1999). Local overexpression of thrombomodulin for in vivo prevention of arterial thrombosis in a rabbit model. Circ Res 84, 84.
6. Cines D B, Pollak E S, Buck C A, et al (1998). Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91, 3527-3561.
7. Boose J A, Kuismanen E, Gerard R et al. (1989). The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site. Biochemistry 28, 635-643.
8. Zhao X, Gu Z, Attele A S, et al. (1999). Effects of quercetin on the release of endothelin, prostacyclin and tissue plasminogen activator from human endothelial cells in culture. J Ethnopharmacol 67, 279-285.
9. Drieu K (1988). Roken (Ginkgo biloba). Recent results in pharmacology and clinic. In: Funfgeld EW, editor. New York, Springer-Verlag, pp. 32.
10. Jaffe E A, Nachman R L, Becker C G et al. (1973). Culture of human endothelial cells derived from umbilical veins: identification by morphologic and immunologic criteria. J Clin Invest 52, 2745-2756.
11. Robinson J P (Ed). (1993). Handbook of flow cytometry methods. New York, Wiley-Liss, 366-368.
12. Liou J W, Ji Q Wei D Z (Ed). (2003). Pharmacology experiment method-new technique & new method. Beijing, Chemical Industry Publishing Company, pp. 217. (In Chinese)
13. Esmon C T, Fukudome K (1995). Cellular regulation of the protein C pathway. Cell Biol 6, 259-268.
14. Kim Y S, Pyo M K, Park K M, et al (1998). Antiplatelet and antithrombotic effects of a combination of ticlopidine and ginkgo biloba extract (EGb761). Thromb Res 91, 33-38.
15. Frist S T, Taylor H A Jr, Kinrk K A, et al. (1995). Expression of PAI-1,t-PA and u-PA in cultured human umbilical vein endothelial cells derived from racial groups. Thromb Res 77, 279.
16. Kubota Y, Tanaka N, Umega ki K, et al. (2001). Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level. Life Sci 69, 2327-2336.
17. 2+-regulated secretion of tissue-type plasminogen activator and von Willebrand factor in human endothelial cells. Biochem Biophys Acta 1600, 162-167.