Binding and signal transduction characteristics of the nonpeptide vasopressin V1A receptor-selective antagonist YM218 in cultured rat mesangial cells

Pharmacology

Volumn 78, Issue 2, 2006, Pages 81-90

  Tahara, Atsuo ^a   Tsukada, Junko ^a   Tomura, Yuichi ^a   Kusayama, Toshiyuki ^a   Momose, Kazuhiro ^a   Taniguchi, Nobuaki ^a   Suzuki, Takeshi ^a   Yatsu, Takeyuki ^a   Shibasaki, Masayuki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Mesangial cells; V1A receptor; Vasopressin; YM218

Indexed keywords

AE[4,4 DIFLUORO 5 [2 OXO 2 (4 PIPERIDINOPIPERIDINO)ETHYLIDENE] 2,3,4,5 TETRAHYDRO 1H 1 BENZOAZEPINE 1 CARBONYL] 2 METHYL 3 FURANILIDE HEMIFUMARATE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG; VASOPRESSIN RECEPTOR ANTAGONIST; YM 218;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL ASSAY; CELL CULTURE; CELL GROWTH; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; HYPERPLASIA; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SCATCHARD PLOT; SIGNAL TRANSDUCTION; TEMPERATURE DEPENDENCE; TIMED DRUG RELEASE;

ANIMALS; BENZAZEPINES; BINDING, COMPETITIVE; CALCIUM; CELL MEMBRANE; CELLS, CULTURED; MALE; MESANGIAL CELLS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, VASOPRESSIN; SIGNAL TRANSDUCTION;

EID: 33749358572     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095698     Document Type: Article

References (54)

1. Kashgarian M: Mesangium and glomerular disease. Lab Invest 1985;52:569-571.
2. Lovett DH, Ryan JL, Sterzel RB: Stimulation of rat mesangial cell proliferation by macrophage interleukin 1. J Immunol 1983;131:2830-2836.
3. Foidart J, Sraer J, Delarue F, Mahieu P, Ardaillou R: Evidence for mesangial glomerular receptors for angiotensin II linked to mesangial cell contractility. FEBS Lett 1980;121:333-339.
4. Badr KF, Murray JJ, Breyer MD, Takahashi K, Inagami T, Harris RC: Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney: elucidation of signal transduction pathways. J Clin Invest 1989;83:336-342.
5. Jard S, Lombard C, Marie J, Devilliers G: Vasopressin receptors from cultured mesangial cells resemble V1a type. Am J Physiol 1987;253:F41-F49.
6. Ganz MB, Pekar SK, Perfetto MC, Sterzel RB: Arginine vasopressin promotes growth of rat glomerular mesangial cells in culture. Am J Physiol 1988;255:F898-F906.
7. 2+. Am J Physiol 1990;259:F269-F278.
8. Bonventre JV, Skorecki KL, Kreisberg JI, Cheung JY: Vasopressin increases cytosolic free calcium concentration in glomerular mesangial cells. Am J Physiol 1986;251:F94-F102.
9. Takeda K, Meyer-Lehnert H, Kim JK, Schrier RW: AVP-induced Ca fluxes and contraction of rat glomerular mesangial cells. Am J Physiol 1988;255:F142-F150.
10. Mene P, Simonson MS, Dunn MJ: Physiology of the mesangial cell. Physiol Rev 1989;69:1347-1424.
11. Pelech S, Sanghera JS: Mitogen-activated protein kinases: versatile transducers for cell signaling. Trends Biochem Sci 1992;17:233-238.
12. Granot Y, Erikson E, Fridman H, Van Putten V, Williams B, Schrier RW, Maller JL: Direct evidence for tyrosine and threonine phosphorylation and activation of mitogen-activated protein kinase by vasopressin in cultured rat vascular smooth muscle cells. J Biol Chem 1993;268:9564-9569.
13. TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 1992;358:414-417.
14. Pulverer GJ, Kyriakis JM, Avruch J, Nakolakai E, Woodgett JR: Phosphorylation of c-jun mediated by MAP-kinases. Nature 1991;353:670-674.
15. Chen RH, Sarnecki C, Blenis J: Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 1992;12:925-927.
16. Chao TS, Byron KL, Lee KM, Villereal M, Rosner MR: Activation of MAP kinases by calcium-dependent and calcium-independent pathways. J Biol Chem 1992;267:19876-19883.
17. Kribben A, Wieder ED, Li X, Van Putten V, Granot Y, Schrier RW, Nemenoff RA: AVP-induced activation of MAP kinase in vascular smooth muscle cells is mediated through protein kinase C. Am J Physiol 1993;265:C939-C945.
18. Wang Y, Simonson MS, Poussegur J, Dunn MJ: Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells. Biochem J 1992;287:589-594.
19. Kusaka I, Ishikawa S, Higashiyama M, Saito T, Nagasaka S, Saito T: The activation of phospholipase D participates in the mitogenic action of arginine vasopressin in cultured rat glomerular mesangial cells. Endocrinology 1996;137:5421-5428.
20. Ishikawa S, Kawasumi M, Saito T: Simvastatin inhibits the cellular signaling and proliferative action of arginine vasopressin in cultured rat glomerular mesangial cells. Endocrinology 1995;136:1954-1961.
21. Ishikawa S, Kusaka I, Higashiyama M, Nagasaka S, Saito T, Honda K, Saito T: Cellular signaling and proliferative action of AVP in mesangium of SHR: effect of low density lipoprotein. Kidney Int 1996;50:1506-1514.
22. 1a receptors. J Clin Invest 1993;92:224-231.
23. 2 receptor antagonist. J Clin Invest 1996;98:2729-2738.
24. 1b receptor antagonist. J Pharmacol Exp Ther 2002;300:1122-1130.
25. 2 receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther 1997;282:301-308.
26. 2 receptor antagonist, on human AVP receptor subtypes expressed in CHO cells and oxytocin receptors in human uterine smooth muscle cells. Br J Pharmacol 2001;133:746-754.
27. 1A receptor-selective antagonist. Vasc Pharmacol 2005;42:47-55.
28. 1A receptor-selective antagonist, on human vasopressin and oxytocin receptors. Pharmacol Res 2005;51:275-281.
29. 1A receptor. Bioorg Med Chem 2006;14:1827-1837.
30. Kruszynski M, Lammek B, Manning M, Seto J, Haldar J, Sawyer WH: [1-(Beta-mercapto-beta,beta-cyclopentamethylenepropionic-acid),2-(O-methyl) tyrosine] arginine-vasopressin and [1-(beta-mercapto-beta,beta- cyclopentamethylenepropionic acid)] arginine-vasopressin, two highly potent antagonists of the vasopressor response to arginine-vasopressin. J Med Chem 1980;23:364-368.
31. Zaoral M, Kolc J, Sorm F: Amino acids and peptides. LXXII. Synthesis of 1-deamino-8-D-gamma-aminobutyrine-vasopressin, 1-deamino-8-D-lysin-vasopressin, and 1-deamino-8-D-arginine-vasopressin. Coll Czech Chem Commun 1967;32:1250-1257.
32. Kohno M, Horio T, Ikeda M, Yokokawa K, Fukui T, Yasunari K, Kurihara N, Takeda T: Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cells. Kidney Int 1992;42:860-866.
33. 50) of an enzymatic reaction. Biochem Pharmacol 1973;22:3099-3108.
34. Scatchard G: The attraction of proteins for small molecules and ions. Ann NY Acad Sci 1949;51:660-672.
35. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1685;260:3440-3450.
36. 3H]thymidine incorporation assay. J Immunol Methods 1994;170:211-224.
37. Pfeilschifter J: Cross-talk between transmembrane signaling systems: a prerequisite for the delicate regulation of glomerular haemodynamics by mesangial cells. Eur J Clin Invest 1989;19:347-361.
38. Schulze-Lohoff E, Kohler M, Fees H, Reindl N, Sterzel RB: Divergent effects of arginine vasopressin and angiotensin II on proliferation and expression of the immediate early genes c-fos, c-jun and Egr-1 in cultured rat glomerular mesangial cells. J Hypertens 1993;11:127-134.
39. Wolthuis A, Boes A, Rodemann HP, Grond J: Vasoactive agents affect growth and protein synthesis of cultured rat mesangial cells. Kidney Int 1992;41:124-131.
40. Rupprecht HD, Dann P, Sukhatme VP, Sterzel RB, Coleman DL: Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity. Am J Physiol 1992;263:F623-F636.
41. Force T, Kyriakis JM, Avruch J, Bonventre JV: Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells. J Biol Chem 1991;266:6650-6656.
42. 1a antagonist, on human vascular smooth muscle cells. Am J Physiol 1995;268:H404-H410.
43. 1a vasopressin antagonist, SR 49059, on the binding and the mitogenic activity of vasopressin on Swiss 3T3 cells. Biochem Pharmacol 1994;47:633-641.
44. 5 Tyr(Me)AVP] in mesangial cells. Biochem Biophys Res Commun 1993;193:738-743.
45. Okada K, Sasaki R, Ishikawa S, Saito T: Distinct inhibition by non-peptide arginine vasopressin antagonists of vasopressininduced activation of mitogen-activated protein kinase in cultured rat vascular smooth muscle cells. Biochem Biophys Res Commun 1994;200:1155-1160.
46. Schlondorff D: The glomerular mesangial cells: an expanding role for a specialized pericyte. FASEB J 1987;1:272-281.
47. Ruef C, Budde K, Lacy J, Northemann W, Baumann M, Sterzel RB, Coleman DL: Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney Int 1990;38:249-257.
48. Striker LJ, Doi T, Elliot S, Striker GE: The contribution of glomerular mesangial cells to progressive glomerulosclerosis. Semin Nephrol 1989;9:318-328.
49. Ray PE, Bruggeman LA, Horikoshi S, Aguilera G, Klotman PE: Angiotensin II stimulates human fetal mesangial cell proliferation and fibronectin biosynthesis by binding to AT1 receptors. Kidney Int 1994;45:177-184.
50. Wolf G, Haberstroh U, Neilson EG: Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells. Am J Pathol 1992;140:95-107.
51. Edwards RM, Trizna W, Kinter LB: Renal microvascular effects of vasopressin and vasopressin antagonists. Am J Physiol 1989;256:F274-F278.
52. Yamamura Y, Ogawa H, Chihara T, Kondo K, Onogawa T, Nakamura S, Mori T, Tominaga M, Yabuuchi Y: OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist. Science 1991;252:572-574.
53. Otsuka F, Ogura T, Yamauchi T, Oishi T, Hashimoto M, Mimura Y, Makino H: Effects of OPC-21268, a vasopressin V1-receptor antagonist, on expression of growth factors from glomeruli in spontaneously hypertensive rats. Regul Pep 1997;72:87-95.
54. Kurihara I, Saito T, Obara K, Shoji Y, Hirai M, Soma J, Sato H, Imai Y, Abe K: Effect of a nonpeptide vasopressin V1 antagonist (OPC-21268) on experimental accelerated focal glomerulosclerosis. Nephron 1996;73:629-636.