Treatment with cyclohexenonic long-chain fatty alcohol reverses diabetes-induced tracheal dysfunction in the rat

Pharmacology

Volumn 78, Issue 2, 2006, Pages 51-60

  Hanada, Takuya ^a,b   Saito, Motoaki ^a,b   Kanzaki, Susumu ^b  

^a Department of Pathophysiological and Therapeutic Science   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

Diabetes, trachea; M 3 muscarinic receptor; M2 muscarinic receptor; mRNA; N hexacosanol

Indexed keywords

BUFFER; CARBACHOL; EOSIN; GLUCOSE; HEMATOXYLIN; HEXACOSANOL; INSULIN; LONG CHAIN FATTY ACID; MESSENGER RNA; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; POTASSIUM CHLORIDE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DRUG INDUCED DISEASE; ELASTIC FIBER; EPITHELIUM; FIBROBLAST; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; MALE; MUSCLE CONTRACTILITY; MUSCLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; TRACHEA DISEASE;

ANIMALS; BODY WEIGHT; CARBACHOL; DIABETES MELLITUS, EXPERIMENTAL; FATTY ALCOHOLS; FEMALE; IMMUNOHISTOCHEMISTRY; MUSCLE CONTRACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRACHEA;

EID: 33749356246     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095120     Document Type: Article

References (33)

1. Dorje F, Levey AI, Brann MR: Immunological detection of muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues. Mol Pharmacol 1991;40:459-462.
2. Fryer AD, Maclagan J: Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig. Br J Pharmacol 1984;83:973-978.
3. Minette PA, Barnes PJ: Prejunctional inhibitory muscarinic receptors on cholinergic nerves in human and guinea pig airways. J Appl Physiol 1988;64:2532-2537.
4. D'Agostino G, Chiari MC, Grana E, Subissi A, Kilbinger H: Muscarinic inhibition of acetylcholine release from a novel in vitro preparation of the guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol 1990; 342:141-145.
5. Kilbinger H, Schneider R, Siefken H, Wolf D, D'Agostino G: Characterization of prejunctional muscarinic autoreceptors in the guinea-pig trachea. Br J Pharmacol 1991;103:1757-1763.
6. Patel HJ, Barnes PJ, Takahashi T, Tadjkarimi S, Yacoub MH, Belvisi MG: Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea. Am J Respir Crit Care Med 1995;152:872-878.
7. EURODIAB Substudy 2 Study Group: Decreased prevalence of atopic diseases in children with diabetes. J Pediatr 2000;137:470-474.
8. Belmonte KE, Jacoby DB, Fryer AD: Increased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs. Br J Pharmacol 1997;121:1287-1294.
9. Belmonte KE, Fryer AD, Costello RW: Role of insulin in antigen-induced airway eosinophilia and neuronal M2 muscarinic receptor dysfunction. J Appl Physiol 1998;85:1708-1718.
10. Coulson FR, Jacoby DB, Fryer AD: Increased function of inhibitory neuronal M2 muscarinic receptors in trachea and ileum of diabetic rats. Br J Pharmacol 2002;135:1355-1362.
11. Luu B, de Aguilar JLG, Junges CG: Cyclohexenonic long-chain fatty alcohols as neuronal growth stimulators. Molecules 2000;5:1439-1460.
12. Gonzalez de Aguilar JL, Girlanda-Junges C, Coowar D, Duportail G, Loeffler JP, Luu B: Neurotrophic activity of 2,4,4-trimethyl-3-(15- hydroxypentadecyl)-2-cyclohexen-1-one in cultured central nervous system neurons. Brain Res 2001;920:65-73.
13. Azzouz M, Kenel PF, Warter J-M, Poindron P, Borg J: Enhancement of mouse sciatic nerve regeneration by the long chain fatty alcohol, N-hexacosanol. Exp Neurol 1996;138: 189-197.
14. Borg J, Toazara J, Heitter H, Henry M, Schmitt G, Luu B: Neurotrophic effect of naturally occurring long-chain fatty alcohols on cultured CNS neurons. FEBS Lett 1987;213:406-410.
15. Borg J, Kesslak PJ, Cotman CW: Peripheral administration of a long-chain fatty alcohol promotes septal cholinergic neurons survival after fimbria-fornix transection. Brain Res 1990;518:295-298.
16. Watanabe T, Miyagawa I: Effects of long-chain fatty alcohol on peripheral nerve conduction and bladder function in diabetic rats. Life Sci 2002;70:2215-2224.
17. Satoh I, Saito M, Kinoshita Y, Shomori K, Suzuki H, Yamada M, Kono T, Satoh K: Effects of cyclohexenonic long-chain fatty alcohol on diabetic rat trachea. Life Sci 2005;77: 2030-2039.
18. Suzuki H, Saito M, Kinoshita Y, Satoh I, Kono T, Suzuki H, Yamada M, Satoh K: Preventive effects of cyclohexenonic long-chain fatty alcohol on diabetic cystopathy in the rat. Can J Physiol Pharmacol 2005;83:1-7.
19. Kinoshita Y, Saito M, Satoh I, Shomori K, Suzuki H, Yamada M, Kono T, Satoh K: General administration of cyclohexenonic long-chain fatty alcohol ameliorates hyperreactivity of STZ-induced diabetic rat aorta. Life Sci 2006;78:1508-1514.
20. Saito M, Wada K, Ikeda K, Wang ZJ, Smith SD, Foster HE Jr, Nishi K, Weiss RM, Latifpour J: Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome. Eur J Pharmacol 2000;387:253-263.
21. Saito M, Suzuki H, Yamada M, Hikita K, Kobayashi N, Kinoshita Y, Houri D, Miyagawa I, Satoh K: Effect of cyclohexenonic long-chain fatty alcohol on rat overactive bladder induced by bladder neck obstruction. Eur J Pharmacol 2004;501:143-149.
22. Wittwer CT, Ririe KM, Andrew RV, David DA, Gundry RA, Balis UJ: The LightCycler: a microvolume multisample fluorometer with rapid temperature control. Biotechniques 1997;22:176-181.
23. Mitsuya M, Mase T, Tsuchiya Y, Kawakami K, Hattori H, Kobayashi K, Ogino Y, Fujikawa T, Satoh A, Kimura T, Noguchi K, Ohtake N, Tomimoto K. J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg Med Chem 1999;7:2555-2567.
24. Zaagsma J, Roffel AF, Meurs H: Muscarinic control of airway function. Life Sci 1997;60:1061-1068.
25. Preuss JM, Goldie RG: Muscarinic cholinoceptor subtypes mediating tracheal smooth muscle contraction and inositol phosphate generation in guinea pig and rat. Eur J Pharmacol 1999;372:269-277.
26. Cros G, Gies JP, Cahard D, Cohen P, Filipek B, Mongold JJ, Serrano JJ: Impairment of contractility associated with muscarinic supersensitivity in trachea isolated from diabetic rats: lack of correlation with ultrastructural changes or quinuclidinyl benzylate binding to lung membranes. Mol Cell Biochem 1992;109:181-183.
27. Mongold JJ, Cros GH, Michel A, McNeill JH, Serrano JJ: Diabetes-induced rat tracheal segment supersensitivity to carbachol. Can J Physiol Pharmacol 1988;66:660-662.
28. Ozansoy G, Karasu C, Ozcelikay AT: The effect of oral vanadyl treatment on the reactivity of tracheal smooth muscle obtained from insulin-dependent diabetic rats. Gen Pharmacol 1993;24:115-119.
29. Ozansoy G, Karasu C, Altan VM: The effects of acetylcholine on insulin-dependent and non-insulin-dependent diabetic rat tracheal segments. Gen Pharmacol 1993;24:159-164.
30. Saito M, Kinoshita Y, Satoh I, Shinbori C, Suzuki H, Yamada M, Watanabe T, Satoh K: Ability of cyclohexenonic long-chain fatty alcohol to reverse diabetes-induced cystopathy in the rat. Eur Urol, in press.
31. Shinbori C, Saito M, Kinoshita Y, Satoh I, Kono T, Nanba E, Adachi K, Suzuki H, Yamada M, Satoh K: N-Hexacosanol reversed diabetic induced muscarinic hypercontractility of ileum in the rat. Eur J Pharmacol, in press.
32. Girlanda-Junges C, Lutz-Bucher B, Gonzalez de Aguilar JL, Loeffler JP, Luu B: 3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion. Bioorg Med Chem Lett 2000;10:2537-2539.
33. Jover E, Gonzalez de Aguilar JL, Luu B, Lutz-Bucher B: Effect of a cyclohexenonic long-chain fatty alcohol on calcium mobilization. Eur J Pharmacol 2005;516:197-203.