Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands

Protein Science

Volumn 15, Issue 10, 2006, Pages 2244-2256

  Mallya, Meera ^a,c   Campbell, R Duncan ^a,d   Aguado, Begoña ^a,b,e  

^a MRC Rosalind Franklin Centre for Genomics Research   (United Kingdom)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

Cell differentiation; Class III; Filopodia; GPI; Ly 6; MHC

Indexed keywords

GLYPICAN; HYBRID PROTEIN; LIGAND; LYMPHOCYTE ANTIGEN 6; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL ADHESION; CELL DIFFERENTIATION; CELL LINE; CELL MIGRATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE LOCATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MEGAKARYOCYTE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; SWINE;

ANIMALS; ANTIGENS, LY; ERYTHROBLASTS; GLYCOSYLATION; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; K562 CELLS; LIGANDS; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE;

EID: 33749323576     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.062242606     Document Type: Article

References (40)

1. Adermann, K., Wattler, F., Wattler, S., Heine, G., Meyer, M., Forssmann, W.G., and Nehls, M. 1999. Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. Protein Sci. 8: 810-819.
2. Aguado, B. and Campbell, R.D. 1998. Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. J. Biol. Chem. 273: 4096-4105.
3. Apostolopoulos, J., McKenzie, I.F., and Sandrin, M.S. 2000. Ly6d-L, a cell surface ligand for mouse Ly6d. Immunity 12: 223-232.
4. Bamezai, A. 2004. Mouse Ly-6 proteins and their extended family: Markers of cell differentiation and regulators of cell signaling. Arch. Immunol. Ther. Exp. 52: 255-266.
5. Bamezai, A. and Rock, K.L. 1995. Overexpressed Ly-6A.2 mediates cell-cell adhesion by binding a ligand expressed on lymphoid cells. Proc. Natl. Acad. Sci. 92: 4294-4298.
6. Brakenhoff, R.H., Gerretsen, M., Knippels, E.M., van Dijk, M., van Essen, H., Weghuis, D.O., Sinke, R.J., Snow, G.B., and van Dongen, G.A. 1995. The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. J. Cell Biol. 129: 1677-1689.
7. Dalby, M.J., Gadegaard, N., Riehle, M.O., Wilkinson, C.D., and Curtis, A.S. 2004. Investigating filopodia sensing using arrays of defined nano-pits down to 35 nm diameter in size. Int. J. Biochem. Cell Biol. 36: 2005-2015.
8. Davies, A., Simmons, D.L., Hale, G., Harrison, R.A., Tighe, H., Lachmann, P.J., and Waldmann, H. 1989. CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J. Exp. Med. 170: 637-654.
9. de Nooij-van Dalen, A.G., van Dongen, G.A., Smeets, S.J., Nieuwenhuis, E.J., Stigter-van Walsum, M., Snow, G.B., and Brakenhoff, R.H. 2003. Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma. Int. J. Cancer 103: 768-774.
10. de Vet, E.C., Aguado, B., and Campbell, R.D. 2001. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. J. Biol. Chem. 276: 42070-42076.
11. Dessaud, E., Salaun, D., Gayet, O., Chabbert, M., and Delapeyriere, O. 2006. Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development. Mol. Cell. Neurosci. 31: 232-242.
12. English, A., Kosoy, R., Pawlinski, R., and Bamezai, A. 2000. A monoclonal antibody against the 66-kDa protein expressed in mouse spleen and thymus inhibits Ly-6A.2-dependent cell-cell adhesion. J. Immunol. 165: 3763-3771.
13. Fischer, J., Bouadjar, B., Heilig, R., Huber, M., Lefevre, C., Jobard, F., Macari, F., Bakija-Konsuo, A., Ait-Belkacem, F., Weissenbach, J., et al. 2001. Mutations in the gene encoding SLURP-1 in Mal de Meleda. Hum. Mol. Genet. 10: 875-880.
14. Fleming, T.J., O'Huigin, C., and Malek, T.R. 1993. Characterization of two novel Ly-6 genes. Protein sequence and potential structural similarity to α-bungarotoxin and other neurotoxins. J. Immunol. 150: 5379-5390.
15. Gumley, T.P., McKenzie, I.F., and Sandrin, M.S. 1995. Tissue expression, structure and function of the murine Ly-6 family of molecules. Immunol. Cell Biol. 73: 277-296.
16. Hanninen, A., Jaakkola, I., Salmi, M., Simell, O., and Jalkanen, S. 1997. Ly-6C regulates endothelial adhesion and homing of CD8(+) T cells by activating integrin-dependent adhesion pathways. Proc. Natl. Acad. Sci. 94: 6898-6903.
17. Herr, M., Dudbridge, F., Zavattari, P., Cucca, F., Guja, C., March, R., Campbell, R.D., Barnett, A.H., Bain, S.C., Todd, J.A., et al. 2000. Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDM1 in the HLA region on chromosome 6p21. Hum. Mol. Genet. 9: 1291-1301.
18. Horton, R., Wilming, L., Rand, V., Lovering, R.C., Bruford, E.A., Khodiyar, V.K., Lush, M.J., Povey, S., Talbot, C.C.J., Wright, M.W., et al. 2004. Gene map of the extended human MHC. Nat. Rev. Genet. 5: 889-899.
19. Ioka, R.X., Kang, M.J., Kamiyama, S., Kim, D.H., Magoori, K., Kamataki, A., Ito, Y., Takei, Y.A., Sasaki, M., Suzuki, T., et al. 2003. Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1. J. Biol. Chem. 278: 7344-7349.
20. Mallya, M., Campbell, R.D., and Aguado, B. 2002. Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: Five genes with many splice forms. Genomics 80: 113-123.
21. The MHC Sequencing Consortium 1999. Complete sequence and gene map of a human major histocompatibility complex. Nature 401: 921-923.
22. Miwa, J.M., Ibañez-Tallon, I., Crabtree, G.W., Sanchez, R., Sali, A., Role, L.W., and Heintz, N. 1999. lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS. Neuron 23: 105-114.
23. Moller, L.B., Pollanen, J., Ronne, E., Pedersen, N., and Blasi, F. 1993. N-linked glycosylation of the ligand-binding domain of the human urokinase receptor contributes to the affinity for its ligand. J. Biol. Chem. 268: 11152-11159.
24. Newton, J.L., Harney, S.M., Timms, A.E., Sims, A.M., Rockett, K., Darke, C., Wordsworth, B.P., Kwiatkowski, D., and Brown, M.A. 2004. Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritis. Arthritis Rheum. 50: 2122-2129.
25. Noel, L.S., Champion, B.R., Holley, C.L., Simmons, C.J., Morris, D.C., Payne, J.A., Lean, J.M., Chambers, T.J., Zaman, G., Lanyon, L.E., et al. 1998. RoBo-1, a novel member of the urokinase plasminogen activator receptor/CD59/Ly-6/snake toxin family selectively expressed in rat bone and growth plate cartilage. J. Biol. Chem. 273: 3878-3883.
26. Palfree, R.G. 1996. Ly-6-domain proteins - New insights and new members: A C-terminal Ly-6 domain in sperm acrosomal protein SP-10. Tissue Antigens 48: 71-79.
27. Pflugh, D.L., Maher, S.E., and Bothwell, A.L. 2000. Ly-6I, a new member of the murine Ly-6 superfamily with a distinct pattern of expression. J. Immunol. 165: 313-321.
28. Ribas, G., Neville, M.J., and Campbell, R.D. 2001. Single-nucleotide polymorphism detection by denaturing high-performance liquid chromatography and direct sequencing in genes in the MHC class III region encoding novel cell surface molecules. Immunogenetics 53: 369-381.
29. Rudd, P.M., Morgan, B.P., Wormald, M.R., Harvey, D.J., van den Berg, C.W., Davis, S.J., Ferguson, M.A., and Dwek, R.A. 1997. The glycosylation of the complement regulatory protein, human erythrocyte CD59. J. Biol. Chem. 272: 7229-7244.
30. Schroeder Jr., H.W., Zhu, Z.B., March, R.E., Campbell, R.D., Berney, S.M., Nedospasov, S.A., Turetskaya, R.L., Atkinson, T.P., Go, R.C., Cooper, M.D., et al. 1998. Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes. Mol. Med. 4: 72-86.
31. Shetty, J., Wolkowicz, M.J., Digilio, L.C., Klotz, K.L., Jayes, F.L., Diekman, A.B., Westbrook, V.A., Farris, E.M., Hao, Z., Coonrod, S.A., et al. 2003. SAMP14, a novel, acrosomal membrane-associated, glycosyl- phosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. J. Biol. Chem. 278: 30506-30515.
32. Southan, C., Cutler, P., Birrell, H., Connell, J., Fantom, K.G., Sims, M., Shaikh, N., and Schneider, K. 2002. The characterisation of novel secreted Ly-6 proteins from rat urine by the combined use of two-dimensional gel electrophoresis, microbore high performance liquid chromatography and expressed sequence tag data. Proteomics 2: 187-196.
33. Stroncek, D.F., Caruccio, L., and Bettinotti, M. 2004. CD177: A member of the Ly-6 gene superfamily involved with neutrophil proliferation and polycythemia vera. J. Transl. Med. 2: 8.
34. Tarui, T., Mazar, A.P., Cines, D.B., and Takada, Y. 2001. Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction. J. Biol. Chem. 276: 3983-3990.
35. Tsetlin, V. 1999. Snake venom α-neurotoxins and other 'three-finger' proteins. Eur. J. Biochem. 264: 281-286.
36. Tsuji, H., Okamoto, K., Matsuzaka, Y., Iizuka, H., Tamiya, G., and Inoko, H. 2003. SLURP-2, a novel member of the human Ly-6 superfamily that is up-regulated in psoriasis vulgaris. Genomics 81: 26-33.
37. Wilhelm, O.G., Wilhelm, S., Escott, G.M., Lutz, V., Magdolen, V., Schmitt, M., Rifkin, D.B., Wilson, E.L., Graeff, H., and Brunner, G. 1999. Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression. J. Cell. Physiol. 180: 225-235.
38. Wood, W. and Martin, P. 2002. Structures in focus - Filopodia. Int. J. Biochem. Cell Biol. 34: 726-730.
39. Xie, T., Rowen, L., Aguado, B., Ahearn, M.E., Madan, A., Qin, S., Campbell, R.D., and Hood, L. 2003. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. Genome Res. 13: 2621-2636.
40. Zanelli, E., Jones, G., Pascual, M., Eerligh, P., van der Slik, A.R., Zwinderman, A.H., Verduyn, W., Schreuder, G.M., Roovers, E., Breedveld, F.C., et al. 2001. The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci. Hum. Immunol. 62: 75-84.