Down-regulation of key virulence factors makes the Salmonella enterica serovar typhimurium rfaH mutant a promising live-attenuated vaccine candidate

Infection and Immunity

Volumn 74, Issue 10, 2006, Pages 5914-5925

  Nagy, Gabor ^a,b   Danino, Vittoria ^c   Dobrindt, Ulrich ^b   Pallen, Mark ^d   Chaudhuri, Roy ^d   Emödy, Levente ^a   Hinton, Jay C ^c   Hacker, Jörg ^b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; LIVE VACCINE; MUTANT PROTEIN; O ANTIGEN; PROTEIN RFAH; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; BACTERIAL FLAGELLUM; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CHEMOTAXIS; CONTROLLED STUDY; CROSS REACTION; DOWN REGULATION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MACROPHAGE; MICROARRAY ANALYSIS; MICROBIAL ATTENUATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULON; SALMONELLA ENTERICA; SALMONELLA ENTERITIDIS; SALMONELLA TYPHIMURIUM; SALMONELLOSIS; SECRETION; SEROTYPE; SPI 4 GENE; TRANSCRIPTION REGULATION; TYPE III SECRETION SYSTEM; VACCINE PRODUCTION;

ANIMALS; BACTERIAL PROTEINS; CELLS, CULTURED; DOWN-REGULATION; EPITHELIAL CELLS; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MUTATION; REGULON; SALMONELLA TYPHIMURIUM; SALMONELLA VACCINES; TRANS-ACTIVATORS; VACCINES, ATTENUATED; VIRULENCE; VIRULENCE FACTORS;

EID: 33749258050     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00619-06     Document Type: Article

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