Free radicals act as effectors in the growth inhibition and apoptosis of iron-treated Burkitt's lymphoma cells

Free Radical Research

Volumn 40, Issue 8, 2006, Pages 789-797

  Habel, Marie Eve ^a   Jung, Daniel ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

Burkitt's lymphoma; Free radicals; Iron; Oxidative stress

Indexed keywords

2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; FERRIC CITRATE; FREE RADICAL; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MYC PROTEIN; NITRIC OXIDE; NITRIC OXIDE DONOR; PEROXIDE; PEROXYNITRITE; SCAVENGER; TROLOX C;

APOPTOSIS; ARTICLE; BIOACCUMULATION; BURKITT LYMPHOMA; CANCER INHIBITION; CATALYSIS; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DAMAGE; CELL LEVEL; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IRON OVERLOAD; LYMPHOMA CELL; PROTEIN TRANSPORT;

APOPTOSIS; BURKITT LYMPHOMA; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; FERRIC COMPOUNDS; FREE RADICAL SCAVENGERS; FREE RADICALS; HUMANS; HYDROGEN PEROXIDE; IRON; NITRIC OXIDE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-MYC;

EID: 33749250409     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760500484344     Document Type: Article

References (27)

1. Rouault, T and Haile, D and Downey, W and Philpott, C and Tang, C and Samaniego, F and Chin, J and Paul, I and Orloff, D and Harford, J and (1992) An iron-sulfur cluster plays a novel regulatory role in the iron-responsive element binding protein Biometals, 5, pp. 131-140.
2. Samaniego, F and Chin, J and Iwaj, K and Rouault, TA and Klausner, RD. (1994) Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation J Biol Chem, 269, pp. 30904-30910.
3. Aziz, N and Munro, HN. (1987) Iron regulates ferritin mRNA translation through a segment of its 5′ untranslated region Proc Natl Acad Sci USA, 84, pp. 8468-8472.
4. Casey, JL and Hentze, MW and Koeller, DM and Caughman, SW and Rouault, TA and Klausner, RD and Harford, JB. (1988) Iron-responsive elements: Regulatory RNA sequences that control mRNA levels and translation Science, 240, pp. 924-928.
5. Rouault, T and Hentze, M and Caughman, S and Harford, J and Klausner, R. (1988) Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA Science, 241, pp. 1207-1210.
6. Eisenstein, RS and Blemings, KP. (1988) Iron regulatory proteins, iron responsive elements and iron homeostasis J Nutr, 128, pp. 2295-2298.
7. Cairo, G and Recalcati, S and Pietrangelo, A and Minotti, G. (2002) The iron regulatory proteins: Targets and modulators of free radical reactions and oxidative damage Free Radic Biol Med, 32, pp. 1237-1243.
8. Boldt, D. (1999) New perspectives on iron: An introduction Am J Med Sci, 318, pp. 207-212.
9. Galleano, M and Simontacchi, M and Puntarulo, S. (2004) Nitric oxide and iron: Effect of iron overload on nitric oxide production in endotoxemia Mol Aspects Med, 25, pp. 141-154.
10. Cheng, Y and Zak, O and Aisen, P and Harrison, S and Walz, T. (2004) Structure of the human transferrin receptor-transferrin complex Cell, 116, pp. 565-576.
11. Eaton, J and Qian, M. (2002) Molecular bases of cellular iron toxicity Free Radic Biol Med, 32, pp. 833-840.
12. Papanikolaou, G and Pantopoulos, K. (2005) Iron metabolism and toxicity Toxicol Appl Pharmacol, 202, pp. 199-211.
13. Adams, P and Chau, L and White, M and Lazarovits, A. (1991) Expression of transferrin receptors on monocytes in hemochromatosis Am J Hematol, 37, pp. 247-252.
14. Habel, M-E and Lemieux, R and Jung, D. (2005) Iron specific growth inhibition of Burkitt's lymphoma cells in vitro, associated with a decrease in translocated c-myc expression J Cell Physiol, 203, pp. 277-285.
15. Jung, D and Cote, S and Drouin, M and Simard, C and Lemieux, R. (2002) Inducible expression of Bcl-XL restricts apoptosis resistance to the antibody secretion phase in hybridoma cultures Biotec Bioeng, 79, pp. 180-187.
16. Simard, C and Lemieux, R and Côté, S. (2001) Urea substitutes toxic formamide as destabilizing agent in nucleic acid hybridizations with RNA probes Electrophoresis, 22, pp. 2679-2683.
17. Cadet, J and Delatour, T and Douki, T and Gasparutto, D and Pouget, J and Ravanat, J and Sauvaigo, S. (1999) Hydroxyl radicals and DNA base damage Mutat Res, 424, pp. 9-21.
18. Ramana, C and Boldogh, I and Izumi, T and Mitra, S. (1998) Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals Proc Natl Acad Sci USA, 95, pp. 5061-5066.
19. Matthews, J and Botting, C and Panico, M and Morris, H and Hay, R. (1996) Inhibition of NF-κB DNA binding by nitric oxide Nucleic Acids Res, 24, pp. 2236-2242.
20. Kanda, K and Hu, H and Zhang, L and Grandchamps, J and Boxer, L. (2000) NF-κ B activity is required for the deregulation of c-myc expression by the immunoglobulin heavy chain enhancer J Biol Chem, 275, pp. 32338-32346.
21. Park, S and Wei, L. (2003) Regulation of c-myc gene by nitric oxide via inactivating NF-κ B complex in P19 mouse embryonal carcinoma cells J Biol Chem, 278, pp. 29776-29782.
22. Crichton, R and Wilmet, S and Legssyer, R and Ward, R. (2002) Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells J Inorg Biochem, 91, pp. 9-18.
23. Hanson, E and Leibold, E. (1999) Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species Gene Exp, 7, pp. 367-376.
24. 2 on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts J Biol Chem, 276, pp. 19738-19745.
25. Kim, S and Ponka, P. (2003) Role of nitric oxide in cellular iron metabolism Biometals, 16, pp. 125-135.
26. Lipinski, P and Starzynski, R and Drapier, J and Bouton, C and Bartlomiejczyk, T and Sochanowicz, B and Smuda, E and Gajkowska, A and Kruszewski, M. (2005) Induction of iron regulatory protein 1 RNA-binding activity by nitric oxide is associated with a concomitant increase in the labile iron pool: Implications for DNA damage Biochem Biophys Res Commun, 327, pp. 349-355.
27. Wang, J and Chen, G and Pantopoulos, K. (2005) Nitric oxide inhibits the degradation of IRP2 Mol Cell Biol, 25, pp. 1347-1353.