Amino- and glycoconjugates of pyrido[4,3,2-kl]acridine. Synthesis, antitumor activity, and DNA binding

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 22, 2006, Pages 7520-7530

  Bouffier, Laurent ^a   Baldeyrou, Brigitte ^b   Hildebrand, Marie Paule ^b   Lansiaux, Amélie ^b   David Cordonnier, Marie Hélène ^b   Carrez, Danièle ^c   Croisy, Alain ^c   Renaudet, Olivier ^a   Dumy, Pascal ^a   Demeunynck, Martine ^a  

^a UNIVERSITÉ JOSEPH FOURIER   (France)

^b Institut de Recherche sur le Cancer de Lille   (France)

^c INSERM   (France)

Author keywords

Acridine; Antitumor; Cytotoxicity; DNA binding; Pyridoacridine

Indexed keywords

9 CHLORO 4 METHOXY 6 (ALPHA DEXTRO GLUCOPYRANOSYLIMINOMETHYLENE) 7H PYRIDO[4,3,2 KL]ACRIDINE; 9 CHLORO 4 METHOXY 6 (BETA DEXTRO GLUCOPYRANOSYLIMINOMETHYLENE) 7H PYRIDO[4,3,2 KL]ACRIDINE; 9 CHLORO 4 METHOXY 6 (BETA DEXTRO LACTOSYLIMINOMETHYLENE) 7H PYRIDO[4,3,2 KL]ACRIDINE; 9 CHLORO 4 METHOXY 6 (BETA DEXTRO MALTOTRIOSYLIMINOMETHYLENE) 7H PYRIDO[4,3,2 KL]ACRIDINE; 9 CHLORO 6 (2 HYDROXYETHYLAMINO) 4H PYRIDO[4,3,2 KL]ACRIDIN 4 ONE; 9 CHLORO 6 (ALPHA DEXTRO GLUCOPYRANOSYLIMINOMETHYLENE) 4H PYRIDO[4,3,2 KL]ACRIDIN 4 ONE; 9 CHLORO 6 (BETA DEXTRO GLUCOPYRANOSYLIMINOMETHYLENE) 4H PYRIDO[4,3,2 KL]ACRIDIN 4 ONE; 9 CHLORO 6 (BETA DEXTRO LACTOSYLIMINOMETHYLENE) 4H PYRIDO[4,3,2 KL]ACRIDIN 4 ONE; 9 CHLORO 6 (BETA DEXTRO MALTOTRIOSYLIMINOMETHYLENE) 4H PYRIDO[4,3,2 KL]ACRIDIN 4 ONE; 9 CHLORO 6 [2 (DIMETHYLAMINO) 1 ETHYLAMINO] 4H PYRIDO[4,3,2-KL]ACRIDIN 4 ONE; 9 CHLORO 6 [3 (AMINO) 1 PROPYLAMINO] 4H PYRIDO[4,3,2 KL]ACRIDIN 4 ONE; 9 CHLORO 6 [8 (AMINO) 1 OCTYLAMINO] 4H PYRIDO[4,3,2 KL]ACRIDIN 4 ONE; ACRIDINE DERIVATIVE; AMINO ACID; ANTINEOPLASTIC AGENT; GLYCOCONJUGATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG BINDING; DRUG CONJUGATION; DRUG DNA BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTERCALATION COMPLEX;

ACRIDINES; AMINATION; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CIRCULAR DICHROISM; DEOXYRIBONUCLEASE I; DNA; DNA FOOTPRINTING; DNA TOPOISOMERASES, TYPE I; GLYCOSYLATION; HT29 CELLS; HUMANS; MOLECULAR STRUCTURE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSITION TEMPERATURE;

EID: 33749238183     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.010     Document Type: Article

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