Gene expression profile of human airway epithelium induced by hyperoxia in Vivo

American Journal of Respiratory Cell and Molecular Biology

Volumn 35, Issue 4, 2006, Pages 424-435

  Chambellan, Arnaud ^b   Cruickshank, Paul J ^b   McKenzie, Patrick ^b   Cannady, Steven B ^b   Szabo, Katalin ^b   Comhair, Suzy A A ^b   Erzurum, Serpil C ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

Airways; Gene expression; Hyperoxia; Proteasome; Ubiquitin

Indexed keywords

2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); ACETYL COENZYME A ACYLTRANSFERASE; ACTIN RELATED PROTEIN 2; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ALCOHOL DEHYDROGENASE; ANKYRIN; ANTIOXIDANT; CHAPERONE; CYCLIN DEPENDENT KINASE 2; DNA DIRECTED DNA POLYMERASE; DYSTROBREVIN; FK 506 BINDING PROTEIN; GLUTAREDOXIN; HEAT SHOCK PROTEIN 70; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K; KARYOPHERIN BETA; MARCKS PROTEIN; NICOTINIC RECEPTOR; NUCLEAR RECEPTOR COREPRESSOR; OXIDOREDUCTASE; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROTEASOME; PROTEINASE; SCATTER FACTOR RECEPTOR; TISSUE PLASMINOGEN ACTIVATOR; TRANSACTIVATOR PROTEIN; UBIQUITIN; VASCULOTROPIN RECEPTOR 2; ZINC FINGER PROTEIN;

ADULT; ARTICLE; CELL CULTURE; CELL CYCLE REGULATION; CONJUGATION; CULTURE MEDIUM; ENERGY YIELD; ENZYME ACTIVITY; EPITHELIUM CELL; FEMALE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENE INDUCTION; HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; HYPEROXIA; MACROMOLECULE; MALE; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; OXYGEN BREATHING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INDUCTION; RESPIRATORY EPITHELIUM; SYNTHESIS; UBIQUITINATION; UNINDEXED SEQUENCE; VALIDATION PROCESS;

ADENOSINE TRIPHOSPHATE; ADULT; BRONCHI; CELL LINE, TRANSFORMED; CLUSTER ANALYSIS; DOWN-REGULATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYPEROXIA; MALE; OXIDATION-REDUCTION; RESPIRATORY MUCOSA; RNA, MESSENGER; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 33749183080     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2005-0251OC     Document Type: Article

References (68)

1. Comhair SA, Erzurum SC. Antioxidant responses to oxidant-mediated lung diseases. Am J Physiol Lung Cell Mol Physiol 2002;283:L246-L255.
2. Heffner JE, Repine JE. Pulmonary strategies of antioxidant defense. Am Rev Respir Dis 1989;140:531-554.
3. van der Vliet A, Cross CE. Oxidants, nitrosants, and the lung. Am J Med 2000;109:398-421.
4. Rahman I, MacNee W. Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 2000;16:534-554.
5. Grune T, Reinheckel T, Davies KJ. Degradation of oxidized proteins in mammalian cells. FASEB J 1997;11:526-534.
6. Yoo JH, Erzurum SC, Hay JG, Lemarchand P, Crystal RG. Vulnerability of the human airway epithelium to hyperoxia: constitutive expression of the catalase gene in human bronchial epithelial cells despite oxidant stress. J Clin Invest 1994;93:297-302.
7. 2 or cigarette smoke. Am J Respir Cell Mol Biol 2000;23:350-354.
8. Barazzone C, Horowitz S, Donati YR, Rodriguez I, Piguet PF. Oxygen toxicity in mouse lung: pathways to cell death. Am J Respir Cell Mol Biol 1998;19:573-581.
9. Carvalho CR, de Paula Pinto Schettino G, Maranhao B, Bethlem EP. Hyperoxia and lung disease. Curr Opin Pulm Med 1998;4:300-304.
10. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;163:1723-1729.
11. Comroe J. Oxygen toxicity: the effect of inhalation of high concentration of oxygen for 24 hours on normal men at sea level and at a simulated altitude of 18,000 feet. JAMA 1945;128:710-717.
12. Erzurum SC, Danel C, Gillissen A, Chu CS, Trapnell BC, Crystal RG. In vivo antioxidant gene expression in human airway epithelium of normal individuals exposed to 100% O2. J Appl Physiol 1993;75:1256-1262.
13. Sackner MA, Landa J, Hirsch J, Zapata A. Pulmonary effects of oxygen breathing: a 6-hour study in normal men. Ann Intern Med 1975;82:40-43.
14. Danel C, Erzurum SC, Prayssac P, Eissa NT, Crystal RG, Herve P, Baudet B, Mazmanian M, Lemarchand P. Gene therapy for oxidant injury-related diseases: adenovirus-mediated transfer of superoxide dismutase and catalase cDNAs protects against hyperoxia but not against ischemia-reperfusion lung injury. Hum Gene Ther 1998;9:1487-1496.
15. Pietarinen-Runtti P, Raivio KO, Saksela M, Asikainen TM, Kinnula VL. Antioxidant enzyme regulation and resistance to oxidants of human bronchial epithelial cells cultured under hyperoxic conditions. Am J Respir Cell Mol Biol 1998;19:286-292.
16. Grune T, Merker K, Sandig G, Davies KJ. Selective degradation of oxidatively modified protein substrates by the proteasome. Biochem Biophys Res Commun 2003;305:709-718.
17. Erzurum SC, Lemarchand P, Rosenfeld MA, Yoo JH, Crystal RG. Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA. Nucleic Acids Res 1993;21:1607-1612.
18. Lillig CH, Berndt C, Vergnolle O, Lonn ME, Hudemann C, Bill E, Holmgren A. Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor. Proc Natl Acad Sci USA 2005; 102:8168-8173.
19. Liu G, Loraine AE, Shigeta R, Cline M, Cheng J, Valmeekam V, Sun S, Kulp D, Siani-Rose MA. NetAffx: Affymetrix probesets and annotations. Nucleic Acids Res 2003;31:82-86.
20. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 1998;95:14863-14868.
21. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000;25:25-29.
22. Zeeberg BR, Feng W, Wang G, Wang MD, Fojo AT, Sunshine M, Narasimhan S, Kane DW, Reinhold WC, Lababidi S, et al. GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol 2003;4:R28.
23. Reddel RR, Ke Y, Gerwin BI, McMenamin MG, Lechner JF, Su RT, Brash DE, Park JB, Rhim JS, Harris CC. Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res 1988; 48:1904-1909.
24. Comhair SA, Bhathena PR, Farver C, Thunnissen FB, Erzurum SC. Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells. FASEB J 2001;15:70-78.
25. Wu BJ, Morimoto RI. Transcription of the human hsp70 gene is induced by serum stimulation. Proc Natl Acad Sci USA 1985;82:6070-6074.
26. Donati YR, Slosman DO, Polla BS. Oxidative injury and the heat shock response. Biochem Pharmacol 1990;40:2571-2577.
27. Kolodziejski PJ, Musial A, Koo JS, Eissa NT. Ubiquitinatiqn of inducible nitric oxide synthase is required for its degradation. Proc Natl Acad Sci USA 2002;99:12315-12320.
28. Enoksson M, Fernandes AP, Prast S, Lillig CH, Holmgren A, Orrenius S. Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release. Biochem Biophys Res Commun 2005;327:774-779.
29. Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature 2001;410:490-494.
30. Gaston B, Reilly J, Drazen JM, Fackler J, Ramdev P, Arnelle D, Mullins ME, Sugarbaker DJ, Chee C, Singel DJ, et al. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc Natl Acad Sci USA 1993;90:10957-10961.
31. Gerber A, Heimburg A, Reisenauer A, Wille A, Weite T, Buhling F. Proteasome inhibitors modulate chemokine production in lung epithelial and monocytic cells. Eur Respir J 2004;24:40-48.
32. Boncoeur E, Tabary O, Bonvin E, Muselet C, Fritah A, Lefait E, Redeuilh G, Clement A, Jacquot J, Henrion-Caude A. Oxidative stress response results in increased p21(WAF1/CIP1) degradation in cystic fibrosis lung epithelial cells. Free Radic Biol Med 2006;40:75-86.
33. Wong HR, Menendez IY, Ryan MA, Denenberg AG, Wispe JR. Increased expression of heat shock protein-70 protects A549 cells against hyperoxia. Am J Physiol 1998;275:L836-L841.
34. Wu HM, Wen HC, Lin WW. Proteasome inhibitors stimulate interleukin-8 expression via Ras and apoptosis signal-regulating kinase-dependent extracellular signal-related kinase and c-Jun N-terminal kinase activation. Am J Respir Cell Mol Biol 2002;27:234-243.
35. Eguchi Y, Shimizu S, Tsujimoto Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 1997;57:1835-1840.
36. Hackett NR, Heguy A, Harvey BG, O'Connor TP, Luettich K, Flieder DB, Kaplan R, Crystal RG. Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers. Am J Respir Cell Mol Biol 2003;29:331-343.
37. Spira A, Beane J, Shah V, Liu G, Schembri F, Yang X, Palma J, Brody JS. Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proc Natl Acad Sci USA 2004;101:10143-10148.
38. Perkowski S, Sun J, Singhal S, Santiago J, Leikauf GD, Albelda SM. Gene expression profiling of the early pulmonary response to hyperoxia in mice. Am J Respir Cell Mol Biol 2003;28:682-696.
39. Comhair SA, Lewis MJ, Bhathena PR, Hammel JP, Erzurum SC. Increased glutathione and glutathione peroxidase in lungs of individuals with chronic beryllium disease. Am J Respir Crit Care Med 1999;159:1824-1829.
40. Kaminski N, Friedman N. Practical approaches to analyzing results of microarray experiments. Am J Respir Cell Mol Biol 2002;27:125-132.
41. Spira A, Beane J, Pinto-Plata V, Kadar A, Liu G, Shah V, Celli B, Brody JS. Gene expression profiling of human lung tissue from smokers with severe emphysema. Am J Respir Cell Mol Biol 2004;31:601-610.
42. Irizarry RA, Warren D, Spencer F, Kim IF, Biswal S, Frank BC, Gabrielson E, Garcia JG, Geoghegan J, Germino G, et al. Multiple-laboratory comparison of microarray platforms. Nat Methods 2005;2: 345-350.
43. Wright JM, Merlo CA, Reynolds JB, Zeitlin PL, Garcia JGN, Guggino WB, Boyle MP. Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease. Am J Respir Cell Mol Biol 2006;35:327-336.
44. Gruber MP, Coldren CD, Woolum MD, Cosgrove GP, Zeng C, Baron AE, Moore MD, Cool CD, Worthen GS, Brown KK, et al. Human lung project: evaluating variance of gene expression in the human lung. Am J Respir Cell Mol Biol 2006;35:65-71.
45. Strange K. The end of "naive reductionism": rise of systems biology or renaissance of physiology? Am J Physiol Cell Physiol 2005;288:C968-C974.
46. Waxman AB, Einarsson O, Seres T, Knickelbein RG, Warshaw JB, Johnston R, Homer RJ, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. J Clin Invest 1998;101:1970-1982.
47. Ho YS, Dey MS, Crapo JD. Antioxidant enzyme expression in rat lungs during hyperoxia. Am J Physiol 1996;270:L810-L818.
48. Rahman I, Mulier B, Gilmour PS, Watchorn T, Donaldson K, Jeffery PK, MacNee W. Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB. Biochem Pharmacol 2001;62:787-794.
49. Ray S, Watkins DN, Misso NL, Thompson PJ. Oxidant stress induces gamma-glutamylcysteine synthetase and glutathione synthesis in human bronchial epithelial NCI-H292 cells. Clin Exp Allergy 2002;32:571-577.
50. Rahman I, Bel A, Mulier B, Donaldson K, MacNee W. Differential regulation of glutathione by oxidants and dexamethasone in alveolar epithelial cells. Am J Physiol 1998;275:L80-L86.
51. van Klaveren RJ, Demedts M, Nemery B. Cellular glutathione turnover in vitro, with emphasis on type II pneumocytes. Eur Respir J 1997;10:1392-1400.
52. Cho HY, Jedlicka AE, Reddy SP, Kensler TW, Yamamoto M, Zhang LY, Kleeberger SR. Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 2002;26:175-182.
53. Ho YS, Magnenat JL, Bronson RT, Cao J, Gargano M, Sugawara M, Funk CD. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem 1997;272:16644-16651.
54. McGrath SA. Induction of p21WAF/CIP1 during hyperoxia. Am J Respir Cell Mol Biol 1998;18:179-187.
55. Corroyer S, Maitre B, Cazals V, Clement A. Altered regulation of G1 cyclins in oxidant-induced growth arrest of lung alveolar epithelial cells: accumulation of inactive cyclin E-DCK2 complexes. J Biol Chem 1996;271:25117-25125.
56. O'Reilly MA, Staversky RJ, Watkins RH, Reed CK, de Mesy Jensen KL, Finkelstein JN, Keng PC. The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am J Respir Cell Mol Biol 2001;24:703-710.
57. Helt CE, Staversky RJ, Lee YJ, Bambara RA, Keng PC, O'Reilly MA. The Cdk and PCNA domains on p21Cip1 both function to inhibit G1/S progression during hyperoxia. Am J Physiol Lung Cell Mol Physiol 2004;286:L506-L513.
58. Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature 2003;426:895-899.
59. Horibe T, Gomi M, Iguchi D, Ito H, Kitamura Y, Masuoka T, Tsujimoto I, Kimura T, Kikuchi M. Different contributions of the three CXXC motifs of human protein-disulfide isomerase-related protein to isomerase activity and oxidative refolding. J Biol Chem 2004;279:4604-4611.
60. Ciechanover A. Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 2005;6:79-87.
61. Zeitlin PL, Gail DB, Banks-Schlegel S. Protein processing and degradation in pulmonary health and disease. Am J Respir Cell Mol Biol 2003; 29:642-645.
62. Allen CB, White CW. Glucose modulates cell death due to normobaric hyperoxia by maintaining cellular ATP. Am J Physiol 1998;274:L159-L164.
63. Aulak KS, Koeck T, Crabb JW, Stuehr DJ. Dynamics of protein nitration in cells and mitochondria. Am J Physiol Heart Circ Physiol 2004;286:H30-H38.
64. Kazzaz JA, Xu J, Palaia TA, Mantell L, Fein AM, Horowitz S. Cellular oxygen toxicity. Oxidant injury without apoptosis. J Biol Chem 1996; 271:15182-15186.
65. Mantell LL, Lee PJ. Signal transduction pathways in hyperoxia-induced lung cell death. Mol Genet Metab 2000;71:359-370.
66. Lecker SH, Jagoe RT, Gilbert A, Gomes M, Baracos V, Bailey J, Price SR, Mitch WE, Goldberg AL. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J 2004;18:39-51.
67. Miyoshi N, Oubrahim H, Chock PB, Stadtman ER. Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Proc Natl Acad Sci USA 2006;103:1727-1731.
68. Dudoit SD, Y. Y., Callow MJ, Speed TP. Statistical methods for identifying differently expressed genes in replicated cDNA microarray experiments. Technical Report #578. Stanford: Stanford University; 2000. p. 38.