Characterization of PLGA microparticles as a drug carrier for 3-ethoxycarbonyl-2H-benzofuro[3,2-f]-1-benzopyran-2-one. Ultrastructural study of cellular uptake and intracellular distribution

Drug Delivery

Volumn 13, Issue 6, 2006, Pages 447-454

  Gomes, Anderson J ^a,d   Faustino, Adriana S ^a   Machado, Antonio Eduardo H ^a   Zaniquelli, Maria Elisabete D ^b   De Paula Rigoletto, Thaís ^b   Lunardi, Claure Nain ^b   Lunardi, Laurelúcia O ^c  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^d FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

Author keywords

Microparticles; Psoralen; PUVA Therapy; Ultrastructure

Indexed keywords

3 ETHOXYCARBONYL 2H BENZOFURO[3,2 F] 1 BENZOPYRAN 2 ONE; DRUG CARRIER; KETONE DERIVATIVE; POLYGLYCOLIC ACID; PSORALEN; UNCLASSIFIED DRUG;

ALKALINITY; ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CELL DAMAGE; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM VESICLE; DRUG RELEASE; DRUG SCREENING; ENCAPSULATION; ENDOPLASMIC RETICULUM; LIGHT SCATTERING; MACROPHAGE; MITOCHONDRION; NONHUMAN; PERITONEUM CELL; PH; PHOTOCHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; PUVA; RAT; SCANNING ELECTRON MICROSCOPY; ULTRASOUND; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION;

ANIMALS; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; ELECTROCHEMISTRY; FICUSIN; LACTIC ACID; LIGHT; MACROPHAGES; MALE; MICROSCOPY, ELECTRON, SCANNING TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; PHAGOCYTOSIS; POLYGLYCOLIC ACID; POLYMERS; PSORALENS; RATS; RATS, WISTAR; SCATTERING, RADIATION; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBCELLULAR FRACTIONS;

EID: 33749156919     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540600640369     Document Type: Article

References (24)

1. Canton, M., Caffieri, S., Dall' Acqua, F., and Di Lisa, F. 2002. PUVA-induced apoptosis involves mitochondrial dysfunction caused by the opening of the permeability transition pore. FEBS Lett., 522:168-172.
2. Dall'Acqua, F., Vedaldi, D., and Caffieri, S. 1996. The Fundamental Bases of Phototherapy. Milano, Italy: OEMF.
3. Dalla Via, L., Uriarte, E., Quezada, E. et al. 2003. Novel pyrone side tetracyclic psoralen derivatives: synthesis and photobiological evaluation. J. Med. Chem. 46:3800-3810.
4. Garcia, J. T., Farina, J. B., Munguia, O., and LLabrés, M. 1999. Comparative degradation study of biodegradable microspheres of poly(dl-lactide-coglycolide) with poly(ethyleneglycol) derivates. J. Microencaps. 16:83-94.
5. Gomes, A. J., Lunardi, L. O., Marchetti, J. M. et al. 2005. Photobiological and ultrastructural studies of nanoparticle of poly(lactic-co-glycolic acid)-containing bacteriochlorophyll-a as a photosensitizer useful for PDT treatment. Drug Del. 12:1-6.
6. Jeon, H.-J., Jeong, Y.-I., Jang, M.-K. et al. 2000. Effect of solvent on the preparation of surfactant-free poly(DL-lactide-co-glycolide) nanoparticles and norfloxacin release characteristics. Int. J. Pharm. 207:99-108.
7. Kompella, U. B., Bandi, N., and Ayalasomayajula, S. P. 2001. Poly(lactic acid) nanoparticles for sustained release of budesonide. Drug Del. Techn. 1:28-34.
8. Kreuter, J. 2004. Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain. J. Nanosci. Nanotechn. 4:484-488.
9. Kumar, M. N. V. R., Bakowsky, U., and Lehr, C. M. 2004. Preparation and characterization of cationic PLGA nanospheres as DNA carriers. Biomaterials 25(10):1771-1777.
10. Lunardi, C. N., Tedesco, A. C., Kurth, T. H., and Brinn, I. M. 2003. The complex between 9-(n-decanyl)acridone and bovine serum albumin. Part 2. What do fluorescence probes probe? Photochem. Photobiolog. Sci. 2:954-959.
11. Machado, A. E. H. 2004. Presentation in VIII Congresso Latinoamericano de Fotoquímica y Fotobiologia (ELAFOT), La Plata, Argentina. Personal Communication.
12. Machado, A. E. H., Miranda, J. A., Oliveira-Campos, A. M. F. et al. 2001. Photophysical properties of two new psoralen analogs. J. Photochemi. Photobiol. A: Chem. 146:75-81.
13. Middelkamp-Hup, M. A., Pathak, M. A., Parrado, C. et al. 2004. Orally administered polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin. J. Am. Acad Dermatol. 50(1):41-49.
14. Okada, H., and Toguchi, H. 1995. Biodegradable microspheres in drug delivery. Crit. Rev. Therapeut. Drug Carrier Sys. 12(1):1-99.
15. Oliveira, A. M. A. G., Raposo, M. M. M., Oliveira-Campos, A. M. E. et al. 2003. Synthesis of psoralen analogues based on dibenzofuran. Helvet. Chim. Acta 86:2900-2907.
16. Oliveira, A. M. A. G., Raposo, M. M. M., Oliveira-Campos, A. M. F. et al. 2004. Fries rearrangement of dibenzofuran-2-yl ethanoate under photochemical and Lewis-acid-catalysed conditions. Tetrahedron 60:6145-6154.
17. Roop, S., Guy, J., Berl, V. et al. 2004. Synthesis and photocytotoxic activity of new □-methylene-□butyrolactone-psoralen heterodimers. Bioorg. Med. Chem. 12:3619-3625.
18. Rosca, I. D., Watari, F., and Uo, M. 2004. MP formation and its mechanism in single and double emulsion solvent evaporation. J. Control. Rel. 99:271-280.
19. Ruan, G., and Feng, S.-S. 2003. Preparation and characterization of poly(lactic acid)-poly(ethyleneglycol)-poly(lactic acid) (PLA-PEG-PLA) microspheres for controlled release of paclitaxel. Biomaterials 24:5037-5044.
20. Santamaria, A. B., Davis, D. W., Nghiem, D. X. et al. 2002. p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells. Cell Death Differentiation 9:549-560.
21. Schlicher, E. J. A. M., Postma, N. S., Zuidema, J. et al. 1997. Preparation and characterization of poly(d,l-lactic-co-glycolic acid) microspheres containing desferrioxamine. Int. J. Pharmaceut. 153:235-245.
22. Srinath, P., and Diwan, P. V. 1998. Pharmacodynamic and pharmacokinetic evaluation of lipid microspheres of indomethacin. Acta Helvet. 73:199-203.
23. Tsung, M. J., and Burgess, D. J. 2001. Preparation and characterization of gelatin surface modified PLGA microspheres. AAPS Pharm Sci. 3:1-11.
24. Wenjian, W., Wlaschek, M., Hommel, C. et al. 2002. Psoralen plus UVA (PUVA) induced premature senescence as a model for stress-induced premature senescence. Exp. Gerontol. 37:1197-1201.