Design, synthesis and antitumor activity of piperidone inhibitors of farnesyltransferase

Acta Chimica Sinica

Volumn 63, Issue 17, 2005, Pages 1613-1620

  Ge, Yan Li ^a   Jiang, Feng Chao ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antitumor activity; Computer aided drug design; Hypothesis; Piperidone inhibitor of farnesyltransferase; Structure activity relationship

Indexed keywords

EID: 33749149441     PISSN: 05677351     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Kiaris, H.; Spandidos, D. Int. J. Oncol. 1995, 7, 413.
2. Casey, P. J. Science 1995, 265, 221.
3. Stephen, R. D. Johnston Lancet Oncol. 2001, 2, 18.
4. Khosravi-Far, R.; Cox, A. D.; Kato, K. Cell Growth Differ. 1992, 5, 461.
5. Williams, T. M.; Ciccarone, T. M.; MacTough, S. C. J. Med. Chem. 1996, 39, 1345.
6. Schlitzer, M.; Sattler, I.; Dahse, H. M. Arch. Pharm. 1999, 332, 124.
7. Haluska, P.; Dy, G. K.; Adjei, A. A. Eur. J. Cancer 2002, 38, 1685.
8. Hunt, J. T.; Ding, C. Z.; Batorsky, R. J. Med. Chem. 2000, 43, 3587.
9. Hunt, J. T.; Ving, G. L.; Katerina, L. J. Med. Chem. 1996, 39, 353.
10. Curtin, M. L.; Horjancic, A. S.; Cohen, J. Bioorg. Med. Chem. Lett. 2003, 13, 1367.
11. Nara, S.; Tanaka, R.; Eishima, J. J. Med. Chem. 2003, 46, 2467.
12. Lee, H.; Lee, J.; Lee, S. Bioorg. Med. Chem. Lett. 2001, 11, 3069.
13. Wu, S.-S. Chem. World 2002, 43, 599 (in Chinese).
14. Yu, S.-X.; Zhang, L.-X.; Zeng, Y.-L. J. Shaanxi Chem. Ind. 1999, 25(4), 12 (in Chinese).
15. Ono, N.; Kamimura, A.; Kaji, A. Synthesis 1984, 3, 226.