Sulfur amino acid deprivation in cadmium chloride toxicity in hepatoma cells

Environmental Toxicology and Pharmacology

Volumn 22, Issue 3, 2006, Pages 334-337

  Fotakis, George ^a   Timbrell, John A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cadmium; Cystine; HepG2 cells; HTC cells; Methionine

Indexed keywords

CADMIUM CHLORIDE; CYSTINE; GLUTATHIONE; METHIONINE; SULFUR AMINO ACID;

AMINO ACID DEFICIENCY; ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; DRUG EFFECT; HEPATOMA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 33749023025     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2006.04.006     Document Type: Article

References (15)

1. Almazan G., Liu H., Khorchid A., Sundararajan S., Martinez-Bermudez K.A., and Chemtob S. Exposure of developing oligodendrocytes to cadmium causes HSP72 induction, free radical generation, reduction in glutathione levels, and cell death. Free Radic. Biol. Med. 29 (2000) 858
2. Beyersmann D., and Hechtenberg S. Cadmium, gene regulation, and cellular signaling in mammalian cells. Toxicol. Appl. Pharmacol. 144 (1997) 247
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72 (1976) 248
4. Fotakis G., Semeli E., Anderson D., and Timbrel A.J. Cadmium chloride-induced DNA and lysosomal damage in a hepatoma cell line. Toxicol. In Vitro 19 (2005) 481
5. Griffith W.O. Mammalian sulfur amino acid metabolism: an overview. Methods Enzymol. 143 (1987) 366
6. IARC (International agency for research on cancer): IARC monographs, 1993. Beryllium, Cadmium, Mercury, and exposures in the glass manufacturing industry, vol. 58.
7. Ishihara T., Kobayashi E., Okubo Y., Suwazono Y., Kido T., Nishijyo M., Nakagawa H., and Nogawa K. Association between cadmium concentration in rice and mortality in the Jinzu river basin, Japan. Toxicology 163 (2001) 23
8. Lu C.S., and Huang H. Comparison of sulfur amino acid utilization for GSH synthesis between HepG2 cells and cultured rat hepatocytes. Biochem. Pharmacol. 47 (1994) 859
9. Merrill C.J., Morton P.J.J., and Soileau D.S. Metals. In: Hayes A.W. (Ed). Principles and Methods of Toxicology (2001), Taylor and Francis, Philadelphia 665
10. Ohta H., and Cherian M.G. The influence of nutritional deficiencies on gastrointestinal uptake of cadmium and cadmium-metallonthionein in rats. Toxicology 97 (1995) 71
11. Poirson-Bichat F., Lopez R., Bras A.R., Goncalves, Miccoli L., Bourgeois Y., Demerseman P., Poisson M., Dutrillaux B., and Poupon F.M. Methionine deprivation and methionine analogs inhibit cell proliferation and growth of human xenografted gliomas. Life Sci. 60 (1997) 919
12. Prozialeck C.W., and Lamar C.P. Effects of glutathione on the cytotoxic actions of cadmium in LLC-Pk1 cells. Toxicol. Appl. Pharmacol. 134 (1995) 285
13. Shaikh A.Z., Thanhtam T.V., and Zaman K. Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol. Appl. Pharmacol. 154 (1999) 256
14. Son H.M., Kang W.K., Lee H.C., and Kim G.S. Potentiation of cadmium-induced cytotoxicity by sulfur amino acid deprivation through activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in conjunction with p38 kinase or c-jun N-terminal kinase (JNK), complete inhibition of the potentiated toxicity by U0126 ab ERK 1/2 and p38 kinase inhibitor. Biochem. Pharmacol. 62 (2001) 1379
15. Tully B.D., Collins J.B., Overstreet J.D., Smith S.C., Dinse E.G., Mumtaz M.M., and Chapin E.R. Effects of arsenic, cadmium, chromium, and lead on gene expression regulated by a battery of 13 different promoters in recombinant HepG2 cells. Toxicol. Appl. Pharmacol. 168 (2000) 79