In-vitro toxicity of Ukrain against human Ewing tumor cell lines

Anti-Cancer Drugs

Volumn 17, Issue 9, 2006, Pages 1025-1030

  Lanvers Kaminsky, Claudia ^a   Nolting, Dorothea Maria ^a   Köster, Julia ^a   Schröder, Anke ^a   Sandkötter, Julia ^a   Boos, Joachim ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Chelidonium alkaloids; Cyclophosphamide; Doxorubicin; Etoposide; Ewing tumor; N,N ,N triethylenethiophosphoramide; Ukrain

Indexed keywords

CHELIDONIUM EXTRACT; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; THIOTEPA; UKRAIN; VINCRISTINE;

ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; EWING SARCOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; NITROBLUE TETRAZOLIUM TEST; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; XENOGRAFT;

BERBERINE ALKALOIDS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHELIDONIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; HUMANS; PHENANTHRIDINES; PLANT EXTRACTS; SARCOMA, EWING'S; THIOTEPA;

EID: 33749015441     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cad.0000231467.61911.50     Document Type: Article

References (29)

1. Cordes N, Plasswilm L, Bamberg M, Rodemann HP. Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour cells in vitro against ionizing radiation. Int J Radiat Biol 2002; 78:17-27.
2. Liepins A, Nowicky JW. Activation of spleen cell lytic activity by the alkaloid thiophosphoric acid derivative: Ukrain. Int J Immunopharmacol 1992; 14:1437-1442.
3. Liepins A, Nowicky JW, Bustamante JO, Lam E. Induction of bimodal programmed cell death in malignant cells by the derivative Ukrain (NSC-631570). Drugs Exp Clin Res 1996; 22:73-79.
4. Nowicky J, Greif M, Hamler F, Hiesmayr W, Staub W. Biological activity of Ukrain in vitro and in vivo. Chemioterapia 1987; 6:683-685.
5. Nowicky JW. Ukrain antineoplastic immunostimulant. Drugs Future 1993; 18:1011-1015.
6. Hohenwarter O, Strutzenberger K, Katinger H, Liepins A, Nowicky JW. Selective inhibition of in vitro cell growth by the anti-tumour drug Ukrain. Drugs Exp Clin Res 1992; 18 (Suppl):1-4.
7. Chlopkiewicz B, Marczewska J, Ejchart A, Anuszewska E, Koziorowska J. Evaluation of mutagenic, genotoxic and transforming properties of Ukrain. Drugs Exp Clin Res 1992; 18 (Suppl):31-34.
8. Kleinrok Z, Jagiell-Wojtowicz E, Nowicky JW, Chodkowska A, Feldo M, Matuszek B. Some pharmacological properties of prolonged administration of Ukrain in rodents. Drugs Exp Clin Res 1992; 18 (Suppl):93-96.
9. Kleinrok Z, Jagiello-Wojtowicz E, Matuszek B, Chodkowska A. Basic central pharmacological properties of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. Pol J Pharmacol Pharm 1992; 44:227-239.
10. Danysz A, Kokoschinegg M, Hamler F. Clinical studies of Ukrain in healthy volunteers (phase 1). Drugs Exp Clin Res 1992; 18 (Suppl):39-43.
11. Aschhoff B. Ukrain treatment in a patient with stage IV neuroblastoma. A case report. Drugs Exp Clin Res 1998; 24:243-245.
12. Aschhoff B. Ukrain and hyperthermia treatment in a patient with Ewing's sarcoma (case report). Drugs Exp Clin Res 1998; 24:241-242.
13. Zemskov V, Prokopchuk O, Susak Y, Zemskov S, Tkachenko O, Hodysh Y, et al. Efficacy of Ukrain in the treatment of pancreatic cancer. Langenbecks Arch Surg 2002; 387:84-89.
14. Gansauge F, Ramadani M, Pressmar J, Gansauge S, Muehling B, Stecker K, et al. NSC-631570 (Ukrain) in the palliative treatment of pancreatic cancer. Results of a phase II trial. Langenbecks Arch Surg 2002; 386:570-574.
15. Aschhoff B. Retrospective study of Ukrain treatment in 203 patients with advanced-stage tumors. Drugs Exp Clin Res 2000; 26:249-252.
16. Ernst E, Schmidt K. Ukrain: a new cancer cure? A systematic review of randomised clinical trials. BMC Cancer 2005; 5:69-75.
17. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65:55-63.
18. Tada H, Shiho O, Kuroshima K, Koyama M, Tsukamoto K. An improved colorimetric assay for interleukin 2. J Immunol Methods 1986; 93:157-165.
19. Paulussen M, Frohlich B, Jurgens H. Ewing tumour: incidence, prognosis and treatment options. Paediatr Drugs 2001; 3:899-913.
20. Kolb EA, Kushner BH, Gorlick R, Laverdiere C, Healey JH, LaQuaglia MP, et al. Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults. J Clin Oncol 2003; 21:3423-3430.
21. Pinkerton CR, Bataillard A, Guillo S, Oberlin O, Fervers B, Philip T. Treatment strategies for metastatic Ewing's sarcoma. Eur J Cancer 2001; 37:1338-1344.
22. Rubinstein LV, Shoemaker RH, Paull KD, Simon RM, Tosini S, Skehan P, et al. Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst 1990; 82:1113-1118.
23. Panzer A, Joubert AM, Bianchi PC, Seegers JC. The antimitotic effects of Ukrain, a Chelidonium majus alkaloid derivative, are reversible in vitro. Cancer Lett 2000; 150:85-92.
24. Panzer A, Hamel E, Joubert AM, Bianchi PC, Seegers JC. Ukrain™, a semisynthetic Chelidonium majus alkaloid derivative, acts by inhibition of tubulin polymerization in normal and malignant cell lines. Cancer Lett 2000; 160:149-157.
25. Panzer A, Joubert AM, Eloff JN, Albrecht CF, Erasmus E, Seegers JC. Chemical analyses of Ukrain, a semi-synthetic Chelidonium majus alkaloid derivative, fail to confirm its trimeric structure. Cancer Lett 2000; 160:237-241.
26. Habermehl D, Kammerer B, Handrick R, Eldh T, Gruber C, Cordes N, et al. Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. BMC Cancer 2006; 6:14-35.
27. Greving I, Meister V, Monnerjahn C, Muller KM, May B. Chelidonium majus: a rare reason for severe hepatotoxic reaction. Pharmacoepidemiol Drug Saf 1998; 7 (Suppl 1):S66-S69.
28. Stickel F, Poschl G, Seitz HK, Waldherr R, Hahn EG, Schuppan D. Acute hepatitis induced by Greater Celandine (Chelidonium majus). Scand J Gastroenterol 2003; 38:565-568.
29. Benninger J, Schneider HT, Schuppan D, Kirchner T, Hahn EG. Acute hepatitis induced by greater celandine (Chelidonium majus). Gastroenterology 1999; 117:1234-1237.