Chemical analyses of Ukrain(TM), a semi-synthetic Chelidonium majus alkaloid derivative, fail to confirm its trimeric structure

Cancer Letters

Volumn 160, Issue 2, 2000, Pages 237-241

  Panzer, A ^a   Joubert, A M ^a   Eloff, J N ^a   Albrecht, C F ^b   Erasmus, E ^c   Seegers, J C ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b Cancer Association of South Africa   (South Africa)

^c NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Alkaloid; Chelidonine; Chelidonium; Chemical analysis; Ukrain

Indexed keywords

ALKALOID; CHELIDONINE; CHELIDONIUM EXTRACT; UKRAIN;

ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; DRUG STRUCTURE; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; COMPARATIVE STUDY; PAPAVER; PLANT EXTRACTS; PLANTS, MEDICINAL; POWDERS; SPECTRUM ANALYSIS, MASS;

CHELIDONIUM; CHELIDONIUM MAJUS;

EID: 0034727786     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00595-4     Document Type: Article

References (13)

1. Pharmacological activities of Chelidonium majus L, (Papaveraceae)
2. Chelidonium majus L.- das Schollkraut
3. Preliminary studies on the effect of Ukrain (Tris(2-([5bS-(5ba6b,12ba)]-5b,6,7,12b,13,14-hexahydro-13-methyl[ 1,3]benzodioxolo[5,6-v]-1-3-dioxolo[4,5-i]phenanthridinium-6-ol]- Ethaneaminyl) Phosphinesulfide.6HCl) on the immunological response in patients with malignant tumours
4. Enhancement of macrophage tumouricidal activity by the alkaloid derivative Ukrain. In vitro and in vivo studies
5. Clinical studies of Ukrain in healthy volunteers (phase 1)
6. Influence of Ukrain on patients with surgically treated breast cancer. Part I. Clinical and laboratory parameters
7. Selective inhibition of in vitro cell growth by the anti-tumour drug Ukrain
8. Selective induction of programmed cell death (apoptosis) in malignant cells by the alkaloid derivative Ukrain (NSC-613570)
9. Ukrain is selectively cytostatic and/or cytotoxic to human tumor and HIV-infected cells, but not to normal human cells
10. Ukrain(TM), a semisynthetic Chelidonium majus alkaloid derivative, acts by inhibition of tubulin polymerisation in normal and malignant cell lines
11. Use of guanidine hydrochloride and ammonium sulfate in comprehensive in-line sorption enrichment of xenobiotics in biological fluids by high-performance liquid chromatography
12. Quantitative Dunnschichtchromatographie der Chelidonium-Hauptalkaloide