Efficacy of Ukrain in the treatment of pancreatic cancer

Langenbeck's Archives of Surgery

Volumn 387, Issue 2, 2002, Pages 84-89

  Zemskov, Volodimir ^a   Prokopchuk, Olga ^a,b   Susak, Yaroslav ^a   Zemskov, Sergiy ^a   Tkachenko, Olexander ^a   Hodysh, Yuriy ^c   Nowicky, Wassil ^c  

^a BOGOMOLETS NATIONAL MEDICAL UNIVERSITY   (Ukraine)

^b UNIVERSITY OF ULM   (Germany)

^c Ukrainian Anti Cancer Institute   (Austria)

Author keywords

Palliative surgery; Pancreatic cancer; Ukrain (NSC 631570)

Indexed keywords

ASCORBIC ACID; NSC 631570; UKRAIN;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HUMAN; MALE; MUSCLE WEAKNESS; PAIN ASSESSMENT; PANCREAS CANCER; PARESTHESIA; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROGNOSIS; PRURITUS; QUALITY OF LIFE; SURVIVAL TIME;

ADULT; AGED; AGED, 80 AND OVER; ALKALOIDS; ANTINEOPLASTIC AGENTS; BERBERINE ALKALOIDS; FEMALE; HUMANS; MALE; MIDDLE AGED; PALLIATIVE CARE; PANCREATIC NEOPLASMS; PHENANTHRIDINES; PILOT PROJECTS; PROGNOSIS; QUALITY OF LIFE;

EID: 0036937780     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-002-0293-y     Document Type: Article

References (20)

1. Seeber S, Schütte J (1995) Therapiekonzepte Onkologie. Springer, Berlin Heidelberg New York
2. Fischer DS, Tish Knobf M, Durivage HJ (1997) The cancer chemotherapy handbook. Mosby, St Louis
3. Scnall SF, Macdonalds JS (1996) Chemotherapy of adenocarcinoma of the pancreas. Semin Oncol 23:220-228
4. Alter CL (1996) Palliative and supportive care of patients with pancreas cancer. Semin Oncol 23:229-240
5. Casper ES, Green MR, Kelsen DP, et al (1994) Phase II trial of gemcitabine (2′,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs 12:29-34
6. Burris HA, Moore MJ, Andersen J, et al (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15:2403-2413
7. Liepins A, Nowicky JW (1992) Activation of spleen cell lytic activity by the alkaloid thiophosphoric acid derivative: Ukrain. Int J Immunopharmacol 14:8:1437
8. Vatanasapt V, Wongpratoom W, Mairiang P, Mairiang E, Chaiyakam C, Buddhisawasd V, Pairojkul C, Nowicky JW (1991) Preliminary report on clinical experience in the use of Ukrain. Thai Cancer J 17:20
9. Musianowycz J, Judmajer F, Manfreda D, Spängler P, Albrecht H, Hoffmann J, Meijer D (1992) Clinical studies of Ukrain in terminal cancer patients (phase II). Drugs Exp Clin Res 18:45
10. Staniszewski A, Slesak B, Kolodziej J, Harlozinska-Smyrka A, Nowicky JW (1992) Lymphocyte subsets in patients with lung cancer treated with thiophosphoric acid alkaloid derivatives from Chelidonium majus L (Ukrain). Drugs Exp Clin Res 18:63
11. Bondar G, Borota A, Yakovets Y, Zolotukhin S (1998) Comparative evaluation of the complex treatment of rectal cancer patients (chemotherapy and X-ray therapy, Ukrain monotherapy). Drugs Exp Clin Res 24:5-6
12. Uglyanitsa K, Nefyodov L, Nowicky JW, Brzosko W (1998) The effect of Ukrain on cancer of the urinary bladder. 17th International Cancer Congress, Rio de Janeiro, 24-28 August
13. Nowicky JW, Greif M, Hamler F, Hiesmayr W, Staub W (1988) Macroscopic UV-marking through affinity. J Tumor Marker Oncol 33:4
14. Liepins A, Nowicky JW (1991) Ukrain is selectively cytostatic and/or cytotoxic to human tumor and HIV-infected cells but not to normal human cells. In: Recent Advances in Chemotherapy, Anticancer Section, Proceedings of the 17th International Congress of Chemotherapy, Berlin
15. Nowicky JW, Hiesmayr W, Nowicky W, Liepins A (1996) Influence of Ukrain on human xenografts in vitro. Drugs Exp Clin Res 22 [Suppl]
16. Liepins A, Nowicky JW, Bustamante JO, Lam E (1996) Induction of bimodal programmed cell death in malignant cells by the derivative Ukrain (NSC-631570). Drugs Exp Clin Res 22 [Suppl]
17. Kolshelnick Y, Moskvina E, Binder BR, Nowicky JW (1998) Ukrain (NSC-631570) inhibits angiogenic differentiation of human endothelial cells in vitro. Abstracts, 17th International Cancer Congress (Brazil), pp 91-95
18. Sulkowski U, Buchler M, Pederzoli P, Arnold R, Dinse P, Kay A, Haus U, Beger G (1999) A phase II study of high-dose octreotide in patients with unresectable pancreatic carcinoma. Eur J Cancer 35:1805-1808
19. David AK, Vaughn DJ, Holroyde CP, Armstead B, Haller DG (2000) A phase II trial of 5-fluorouracil, leucovorin, and interferon alpha 2A (IFN-alpha 2a) in metastatic pancreatic carcinoma: a Penn Cancer Clinical Trials Group (PCCTG) trial. Am J Clin Oncol 23:37-39
20. Gansauge F, Ramadani M, Pressmar J, Gansauge S, Muehling B, Stecker K, Cammerer G, Leder G, Beger HG (2002) NSC-631570 (Ukrain) in the palliative treatment of pancreatic cancer. Results of a phase II trial. Langenbecks Arch Surg 386:570-574