Sarcomatoid carcinomas of the lung - Are these histogenetically heterogeneous tumors?

Virchows Archiv

Volumn 449, Issue 4, 2006, Pages 455-461

  Blaukovitsch, Markus ^a   Halbwedl, Iris ^a   Kothmaier, Hannelore ^a   Gogg Kammerer, Margit ^a   Popper, Helmut H ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

c Jun; CGH; Comparative genomic hybridization; Epithelial mesenchymal transition; Fascin; Immunohistochemistry; Lung carcinomas; Notch; Sarcomatoid carcinomas; Vimentin

Indexed keywords

ANTIBODY; BETA CATENIN; FASCIN; GLYCOGEN SYNTHASE KINASE 3BETA; NOTCH1 RECEPTOR; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; VIMENTIN;

ARTICLE; CELL MEMBRANE; CHROMOSOME 19; CHROMOSOME 1Q; CHROMOSOME 3Q; CHROMOSOME 7; CHROMOSOME 8Q; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOPLASM; EPITHELIUM CELL; EPITHELIUM TUMOR; GENE OVEREXPRESSION; GIANT CELL; HISTOGENESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SARCOMA; MESENCHYME CELL; PRIORITY JOURNAL; SARCOMATOID CARCINOMA; SIGNAL TRANSDUCTION; SPINDLE CELL; TUMOR CLASSIFICATION; TUMOR DIFFERENTIATION;

CARCINOMA, NON-SMALL-CELL LUNG; CARCINOSARCOMA; CHROMOSOME ABERRATIONS; DNA, NEOPLASM; GENETIC VARIATION; HUMANS; LUNG NEOPLASMS; NUCLEIC ACID HYBRIDIZATION; SPECTRAL KARYOTYPING; TUMOR MARKERS, BIOLOGICAL; VARIATION (GENETICS);

EID: 33748990134     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-006-0256-8     Document Type: Article

References (21)

1. Adams JC (2004) Roles of fascin in cell adhesion and motility. Curr Opin Cell Biol 16:590-596
2. Akhurst RJ, Derynck R (2001) TGF-beta signaling in cancer - a double-edged sword. Trends Cell Biol 11:S44-S51
3. Fishback NF, Travis WD, Moran CA, Guinee DG Jr, McCarthy WF, Koss MN (1994) Pleomorphic (spindle/giant cell) carcinoma of the lung. A clinicopathologic correlation of 78 cases. Cancer 73:2936-2945
4. Gotzmann J, Mikula M, Eger A, Schulte-Hermann R, Foisner R, Beug H, Mikulits W (2004) Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis. Mutat Res 566:9-20
5. Grego-Bessa J, Diez J, Timmerman L, de la Pompa JL (2004) Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw. Cell Cycle 3:718-721
6. Guarino M, Micheli P, Pallotti F, Giordano F (1999) Pathological relevance of epithelial and mesenchymal phenotype plasticity. Pathol Res Pract 6(195):379-389
7. Halbwedl I, Ullmann R, Kremser ML, Man YG, Isadi-Moud N, Lax S, Denk H, Popper HH, Tavassoli FA, Moinfar F (2005) Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization. Gynecol Oncol 2:582-587
8. Holst VA, Finkelstein S, Colby TV, Myers JL, Yousem SA (1997) p53 and K-ras mutational genotyping in pulmonary carcinosarcoma, spindle cell carcinoma, and pulmonary blastoma: implications for histogenesis. Am J Surg Pathol 21:801-811
9. Ilyas M (2005) Wnt signalling and the mechanistic basis of tumour development. J Pathol 205:130-144
10. Jiang F, Yin Z, Caraway NP, Li R, Katz RL (2004) Genomic profiles in stage I primary non small cell lung cancer using comparative genomic hybridization analysis of cDNA microarrays. Neoplasia 6:623-635
11. Kallionemi A, Kallionemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258:818-821
12. Klymkowsky MW (2005) Editorial. β-catenin and its regulatory network. Human Pathol 36:225-227
13. Pelosi G, Fragetta F, Nappi O, Pastorino U, Maisonneuve P, Pasini F, Iannucci A, Solli P, Musavinasab HS, de Manzoni G, Terzi A, Viale G (2003) Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases. Am J Surg Pathol 27:1203-1215
14. Pelosi G, Scarpa A, Manzotti M, Veronesi G, Spaggiari L, Fragetta F, Nappi O, Benino E, Pasini F, Antonello D, Iannucci A, Maisonneuve P, Viale G (2004) K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung. Mod Path 17:538-546
15. Rossi G, Cavezza A, Sturm N, Migali M, Facciolongo N, Longo L, Maiorana A, Brambilla E (2003) Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol 27:311-324
16. Thompson L, Chang B, Barsky SH (1996) Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis. Am J Surg Pathol 20:277-285
17. Torenbeek R, Hermsen MA, Meijer GA, Baak JPA, Meijer CJLM (1999) Analysis by comparative genomic hybridization of epithelial and spindle cell components in sarcomatoid carcinoma and carcinosarcoma: histogenetic aspects. J Pathol 189:338-343
18. Travis W, Brambilla E (2004) Pathology and genetics of tumours of the lung, pleura, thymus and heart. WHO, Lyon
19. Sy SM, Wong N, Lee TW, Tse G, Mok TS, Fan B, Pang E, Johnson PJ, Yim A (2004) Distinct patterns of genetic alterations in adenocarcinoma and squamous cell carcinoma of the lung. Eur J Cancer 40:1082-1094
20. Weiss MM, Hermsen MA, Meijer GA, van Grieken NC, Baak JP, Kuipers EJ, van Diest PJ (1999) Comparative genomic hybridisation. Mol Pathol 52:243-251
21. Wu Y, Zhang X, Zehner ZE (2003) c-Jun and the dominant-negative mutant, TAM67, induce vimentin gene expression by interacting with the activator Sp1. Oncogene 22:8891-8901