RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells

Virology

Volumn 354, Issue 1, 2006, Pages 103-115

  Burnside, Kellie L ^a   Ryan, Jonathan T ^a   Bielefeldt Ohmann, Helle ^b   Gregory Bruce, A ^a   Thouless, Margaret E ^a   Tsai, Che Chung ^b   Rose, Timothy M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Kaposi's sarcoma; KSHV; LANA; Latency associated; ORF73; Retroperitoneal fibromatosis; RFHV; Rhadinovirus

Indexed keywords

GLUTAMIC ACID; GLUTAMINE; LATENCY ASSOCIATED NUCLEAR ANTIGEN; MONOCLONAL ANTIBODY; PROLINE; SERINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CARBOXY TERMINAL SEQUENCE; FIBROMATOSIS; HERPES VIRUS; HUMAN HERPESVIRUS 8; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MACACA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETROPERITONEAL FIBROMATOSIS; RETROPERITONEAL FIBROMATOSIS HERPESVIRUS; TUMOR CELL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, VIRAL; CELL NUCLEUS; CLONING, MOLECULAR; DNA, VIRAL; FIBROMA; IMMUNOHISTOCHEMISTRY; MACACA NEMESTRINA; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; OPEN READING FRAMES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RETROPERITONEAL NEOPLASMS; RHADINOVIRUS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8; MACACA; MACACA NEMESTRINA; RHADINOVIRUS; SIMIAE;

EID: 33748970487     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2006.06.022     Document Type: Article

References (56)

1. Alexander L., Denekamp L., Knapp A., Auerbach M.R., Damania B., and Desrosiers R.C. The primary sequence of rhesus monkey rhadinovirus isolate 26-95: sequence similarities to Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus isolate 17577. J. Virol. 74 7 (2000) 3388-3398
2. Ambinder R.F., Mullen M.A., Chang Y.N., Hayward G.S., and Hayward S.D. Functional domains of Epstein-Barr virus nuclear antigen EBNA-1. J. Virol. 65 3 (1991) 1466-1478
3. An F.Q., Compitello N., Horwitz E., Sramkoski M., Knudsen E.S., and Renne R. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrest. J. Biol. Chem. 280 5 (2005) 3862-3874
4. Auerbach M.R., Czajak S.C., Johnson W.E., Desrosiers R.C., and Alexander L. Species specificity of macaque rhadinovirus glycoprotein B sequences. J. Virol. 74 1 (2000) 584-590
5. Ballestas M.E., Chatis P.A., and Kaye K.M. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science 284 5414 (1999) 641-644
6. Bielefeldt-Ohmann H., Barouch D.H., Bakke A.M., Bruce A.G., Durning M., Grant R., Letvin N.L., Ryan J.T., Schmidt A., Thouless M.E., and Rose T.M. Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta). Vet. Pathol. 42 3 (2005) 391-396
7. Borah S., Verma S.C., and Robertson E.S. ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb. J. Virol. 78 19 (2004) 10336-10347
8. Boshoff C., Schulz T.F., Kennedy M.M., Graham A.K., Fisher C., Thomas A., McGee J.O., Weiss R.A., and JJ O.L. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat. Med. 1 12 (1995) 1274-1278
9. Bruce A.G., Bakke A.M., Thouless M.E., and Rose T.M. Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons. Virol J. 2 1 (2005) 2
10. Cesarman E., Chang Y., Moore P.S., Said J.W., and Knowles D.M. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas [see comments]. N. Engl. J. Med. 332 18 (1995) 1186-1191
11. Chang Y., Cesarman E., Pessin M.S., Lee F., Culpepper J., Knowles D.M., and Moore P.S. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma [see comments]. Science 266 5192 (1994) 1865-1869
12. Cotter II M.A., and Robertson E.S. The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. Virology 264 2 (1999) 254-264
13. Cotter II M.A., Subramanian C., and Robertson E.S. The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen binds to specific sequences at the left end of the viral genome through its carboxy-terminus. Virology 291 2 (2001) 241-259
14. DeWire S.M., and Damania B. The latency-associated nuclear antigen of rhesus monkey rhadinovirus inhibits viral replication through repression of Orf50/Rta transcriptional activation. J. Virol. 79 5 (2005) 3127-3138
15. Dittmer D., Lagunoff M., Renne R., Staskus K., Haase A., and Ganem D. A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. J. Virol. 72 10 (1998) 8309-8315
16. Evans J.S., Levine B.A., Trayer I.P., Dorman C.J., and Higgins C.F. Sequence-imposed structural constraints in the TonB protein of E. coli. FEBS Lett. 208 2 (1986) 211-216
17. Friborg Jr. J., Kong W., Hottiger M.O., and Nabel G.J. p53 inhibition by the Lana protein of Kshv protects against cell death. Nature 402 6764 (1999) 889-894
18. Gao S.J., Zhang Y.J., Deng J.H., Rabkin C.S., Flore O., and Jenson H.B. Molecular polymorphism of Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes. J. Infect. Dis. 180 5 (1999) 1466-1476 (published erratum appears in J Infect Dis 1999 Nov;180(5):1756)
19. Glenn M., Rainbow L., Aurad F., Davison A., and Schulz T.F. Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus. J. Virol. 73 8 (1999) 6953-6963
20. Greensill J., Sheldon J.A., Renwick N.M., Beer B.E., Norley S., Goudsmit J., and Schulz T.F. Two distinct gamma-2 herpesviruses in African green monkeys: a second gamma-2 herpesvirus lineage among old world primates?. J. Virol. 74 3 (2000) 1572-1577
21. Kedes D.H., Lagunoff M., Renne R., and Ganem D. Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J. Clin Invest. 100 10 (1997) 2606-2610
22. Kellam P., Boshoff C., Whitby D., Matthews S., Weiss R.A., and Talbot S.J. Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genome. J. Hum. Virol. 1 1 (1997) 19-29
23. Kellam P., Bourboulia D., Dupin N., Shotton C., Fisher C., Talbot S., Boshoff C., and Weiss R.A. Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8. J. Virol. 73 6 (1999) 5149-5155
24. Komatsu T., Ballestas M.E., Barbera A.J., Kelley-Clarke B., and Kaye K.M. KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence. Virology 319 2 (2004) 225-236
25. Krithivas A., Young D.B., Liao G., Greene D., and Hayward S.D. Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. J 74 20 (2000) 9637-9645 (Virol 2000 Oct)
26. Lacoste V., Mauclere P., Dubreuil G., Lewis J., Georges-Courbot M.C., and Gessain A. KSHV-like herpesviruses in chimps and gorillas. Nature 407 6801 (2000) 151-152
27. Lacoste V., Mauclere P., Dubreuil G., Lewis J., Georges-Courbot M.C., Rigoulet J., Petit T., and Gessain A. Simian homologues of human gamma-2 and betaherpesviruses in mandrill and drill monkeys. J. Virol. 74 24 (2000) 11993-11999
28. Lacoste V., Mauclere P., Dubreuil G., Lewis J., Georges-Courbot M.C., and Gessain A. A novel gamma 2-herpesvirus of the Rhadinovirus 2 lineage in chimpanzees. Genome Res. 11 (2001) 1511-1519
29. Lan K., Kuppers D.A., Verma S.C., and Robertson E.S. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency. J. Virol. 78 12 (2004) 6585-6594
30. Lan K., Kuppers D.A., Verma S.C., Sharma N., Murakami M., and Robertson E.S. Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latency. J. Virol. 79 12 (2005) 7453-7465
31. London W.T., Sever J.L., Madden D.L., Henrickson R.V., Gravell M., Maul D.H., Dalakas M.C., Osborn K.G., Houff S.A., and Gardner M.B. Experimental transmission of simian acquired immunodeficiency syndrome (SAIDS) and Kaposi-like skin lesions. Lancet 2 8355 (1983) 869-873
32. Mattsson K., Kiss C., Platt G.M., Simpson G.R., Kashuba E., Klein G., Schulz T.F., and Szekely L. Latent nuclear antigen of Kaposi's sarcoma herpesvirus/human herpesvirus-8 induces and relocates RING3 to nuclear heterochromatin regions. J. Gen. Virol. 83 Pt 1 (2002) 179-188
33. Piolot T., Tramier M., Coppey M., Nicolas J.C., and Marechal V. Close but distinct regions of human herpesvirus 8 latency-associated nuclear antigen 1 are responsible for nuclear targeting and binding to human mitotic chromosomes. J. Virol. 75 8 (2001) 3948-3959
34. Platt G.M., Simpson G.R., Mittnacht S., and Schulz T.F. Latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with RING3, a homolog of the Drosophila female sterile homeotic (fsh) gene. J. Virol. 73 12 (1999) 9789-9795
35. Radkov S.A., Kellam P., and Boshoff C. The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat. Med. 6 10 (2000) 1121-1127
36. Rainbow L., Platt G.M., Simpson G.R., Sarid R., Gao S.J., Stoiber H., Herrington C.S., Moore P.S., and Schulz T.F. The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J. Virol. 71 8 (1997) 5915-5921
37. Renne R., Barry C., Dittmer D., Compitello N., Brown P.O., and Ganem D. Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J. Virol. 75 1 (2001) 458-468
38. Richardson J.P., Beecroft R.P., Tolson D.L., Liu M.K., and Pearson T.W. Procyclin: an unusual immunodominant glycoprotein surface antigen from the procyclic stage of African trypanosomes. Mol. Biochem. Parasitol. 31 3 (1988) 203-216
39. Roditi I., Schwarz H., Pearson T.W., Beecroft R.P., Liu M.K., Richardson J.P., Buhring H.J., Pleiss J., Bulow R., Williams R.O., et al. Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei. J. Cell Biol. 108 2 (1989) 737-746
40. Rose T.M., Strand K.B., Schultz E.R., Schaefer G., Rankin Jr. G.W., Thouless M.E., Tsai C.C., and Bosch M.L. Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species. J. Virol. 71 5 (1997) 4138-4144
41. Rose T.M., Ryan J.T., Schultz E.R., Raden B.W., and Tsai C.-C. Analysis of 4.3 Kb of the divergent locus-B of macaque retroperitoneal fibromatosis-associated herpesvirus (RFHV) reveals close similiarity to Kaposi's sarcoma-associated herpesvirus (KSHV) in gene sequence and genome organization. J. Virol. 77 9 (2003) 5084-5097
42. Russo J.J., Bohenzky R.A., Chien M.C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., and Moore P.S. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc. Natl. Acad. Sci. U. S. A. 3 25 (1996) 14862-14867
43. Sarid R., Flore O., Bohenzky R.A., Chang Y., and Moore P.S. Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1). J. Virol. 72 2 (1998) 1005-1012
44. Schultz E.R., Rankin Jr. G.W., Blanc M.P., Raden B.W., Tsai C.C., and Rose T.M. Characterization of two divergent lineages of macaque rhadinoviruses related to Kaposi's sarcoma-associated herpesvirus. J. Virol. 74 10 (2000) 4919-4928
45. Schwam D.R., Luciano R.L., Mahajan S.S., Wong L., and Wilson A.C. Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies. J 74 18 (2000) 8532-8540 (Virol 2000 Sep)
46. Searles R.P., Bergquam E.P., Axthelm M.K., and Wong S.W. Sequence and genomic analysis of a Rhesus macaque rhadinovirus with similarity to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J. Virol. 73 4 (1999) 3040-3053
47. Soulier J., Grollet L., Oksenhendler E., Cacoub P., Cazals-Hatem D., Babinet P., d'Agay M.F., Clauvel J.P., Raphael M., Degos L., et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease [see comments]. Blood 86 4 (1995) 1276-1280
48. Staskus K.A., Zhong W., Gebhard K., Herndier B., Wang H., Renne R., Beneke J., Pudney J., Anderson D.J., Ganem D., and Haase A.T. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J. Virol. 71 1 (1997) 715-7199
49. Szekely L., Kiss C., Mattsson K., Kashuba E., Pokrovskaja K., Juhasz A., Holmvall P., and Klein G. Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin-associated nuclear bodies. J. Gen. Virol. 80 Pt 11 (1999) 2889-2900
50. Tsai C.C., Warner T.F., Uno H., Giddens W.E., and Ochs H.D. Subcutaneous fibromatosis associated with an acquired immune deficiency syndrome in pig-tailed macaques. Am. J. Pathol. 120 1 (1985) 30-37
51. Tsai C.C., Tsai C.C., Roodman S.T., and Woon M.D. Mesenchymoproliferative disorders (MPD) in simian AIDS associated with SRV-2 infection. J. Med. Primatol. 19 3-4 (1990) 189-202
52. Verma S.C., Borah S., and Robertson E.S. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1. J. Virol. 78 19 (2004) 10348-10359
53. Verma S.C., and Robertson E.S. Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus. FEMS Microbiol. Lett. 222 2 (2003) 155-1563
54. Viejo-Borbolla A., and Schulz T.F. Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8): key aspects of epidemiology and pathogenesis. AIDS Rev. 5 4 (2003) 222-229
55. Whitby D., Stossel A., Gamache C., Papin J., Bosch M., Smith A., Kedes D.H., White G., Kennedy R., and Dittmer D.P. Novel Kaposi's sacroma-associated herpesvirus homolog in baboons. J. Virol. 77 14 (2003) 8159-8165
56. Wong L.Y., Matchett G.A., and Wilson A.C. Transcriptional activation by the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen is facilitated by an N-terminal chromatin-binding motif. J. Virol. 78 18 (2004) 10074-10085