Poly(ADP-ribose) polymerase inhibition combined with irradiation: A dual treatment concept to prevent neointimal hyperplasia after endarterectomy

International Journal of Radiation Oncology Biology Physics

Volumn 66, Issue 3, 2006, Pages 867-875

  Beller, Carsten J ^a   Kosse, Jens ^a   Radovits, Tamás ^a   Gerö, Domokos ^b   Krempien, Robert ^a   Gross, Marie Luise ^a   Berger, Irina ^a   Hagl, Siegfried ^a   Szabó, Csaba ^b   Szabó, Gábor ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Endarterectomy; Irradiation; Neointima; Nitrosative stress; PARP inhibition

Indexed keywords

CARDIOVASCULAR SYSTEM; DOSIMETRY; ENZYME INHIBITION; RADIATION EFFECTS;

ENDARTERECTOMY; NEOINTIMA; NITROSATIVE STRESS; PARP INHIBITION;

PATIENT TREATMENT;

INO 1001; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXYNITRITE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD VESSEL WALL; CAROTID ARTERY; CAROTID ENDARTERECTOMY; CONTROLLED STUDY; ENZYME INHIBITION; INCISION; IRRADIATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RESTENOSIS;

ANIMALS; ENDARTERECTOMY, CAROTID; HYPERPLASIA; INDOLES; MALE; PEROXYNITROUS ACID; POLY ADENOSINE DIPHOSPHATE RIBOSE; RADIATION DOSAGE; RATS; RATS, SPRAGUE-DAWLEY; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA; TUNICA INTIMA;

EID: 33748950986     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.06.055     Document Type: Article

References (31)

1. Harrison D., Griendling K.K., Landmesser U., et al. Role of oxidative stress in atherosclerosis. Am J Cardiol 91 (2003) 7A-11A
2. Zalba G., San Jose G., Moreno M.U., et al. Oxidative stress in arterial hypertension: Role of NAD(P)H oxidase. Hypertension 38 (2001) 1395-1399
3. Guigliano D., Ceriello A., and Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 19 (1996) 257-267
4. Azevedo L.C., Pedro M.A., Souza L.C., et al. Oxidative stress as a signaling mechanism of the vascular response to injury; The redox hypothesis of restenosis. Cardiovasc Res 47 (2000) 436-445
5. Mabley J.G., Jagtap P., Perretti M., et al. Anti-inflammatory effects of a novel, potent inhibitor of poly(ADP-ribose) polymerase. Inflamm Res 50 (2001) 561-569
6. Chen M., Zsengeller Z., Xiao C.Y., and Szabo C. Mitochondrial-to-nuclear translocation of apoptosis-inducing factor in cardiac myocytes during oxidant stress: Potential role of poly(ADP-ribose) polymerase-1. Cardiovasc Res 63 (2004) 682-688
7. Beller C.J., Kosse J., Radovits T., et al. Adjunct brachytherapy: A new concept to prevent intimal hyperplasia after surgical endarterectomy?. Eur J Cardiothorac Surg 29 (2006) 334-342
8. Fareh J., Martel R., Kermani P., et al. Cellular effects of beta-particle delivery on vascular smooth muscle cells and endothelial cells: A dose-response study. Circulation 99 (1999) 1477-1484
9. Verin V., Popowski Y., Bochaton-Piallat M.L., et al. Intraarterial beta irradiation induces smooth muscle cell apoptosis and reduces medial cellularity in a hypercholesterolemic rabbit restenosis model. Int J Radiat Oncol Biol Phys 46 (2000) 661-670
10. Wexberg P., Muck K., Windberger U., et al. Adventitial response to intravascular brachytherapy in a rabbit model of restenosis. Wien Klin Wochenschr 116 (2004) 190-195
11. Jagtap P.G., Baloglu E., Southan G.J., et al. Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. J Med Chem 48 (2005) 5100-5103
12. Legan E., and Sisson J.A. Method to denude rat aortic endothelium with saponin for phosphoinositide analysis in vascular smooth muscle. J Pharmacol Methods 23 (1990) 31-39
13. Schultz-Hector S. Prävention der Restenose durch Strahlentherapie-strahlenbiologische Aspekte. In: Hehrlein C. (Ed). Kardiovaskuläre Strahlentherapie (2000), Steinkopff, Darmstadt 49-74
14. Liaudet L., Soriano F.G., Szabo E., et al. Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose) polymerase. Proc Natl Acad Sci USA 97 (2000) 10203-10208
15. McCaffrey T.A. TGF-betas and TGF-β receptors in atherosclerosis. Cytokine Growth Factor Rev 11 (2000) 103-114
16. Szocs K., Lassegue B., Sorescu D., et al. Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol 22 (2002) 21-27
17. Fernet M., Ponette V., Deniaud-Alexandre E., et al. Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation. Int J Radiat Biol 76 (2000) 1621-1629
18. Virag L., and Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 54 (2002) 375-429
19. Zhang C., Yang J., and Jennings L.K. Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery. Am J Physiol Heart Circ Physiol 287 (2004) H659-H666
20. Cregan S.P., Fortin A., MacLaurin J.G., et al. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol 158 (2002) 507-517
21. + depletion and cell death induced by oxidative stress. J Biol Chem 278 (2003) 18426-18433
22. Du X., Matsumura T., Edelstein D., et al. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest 112 (2003) 986-988
23. Finn A.V., Gold H.K., Tang A., et al. A novel rat model of carotid artery stenting for the understanding of restenosis in metabolic diseases. J Vasc Res 39 (2002) 414-425
24. Mezzetti A., Guglielmi M.D., Pierdomenico S.D., et al. Increased systemic oxidative stress after elective endarterectomy: Relation to vascular healing and remodeling. Arterioscler Thromb Vasc Biol 19 (1999) 2659-2665
25. Dusting G.J., Fennessy P., Yin Z., et al. Nitric oxide in atherosclerosis: Vascular protector or villain?. Clin Exp Pharmacol Physiol Suppl 25 (1998) S34-S41
26. Beller C.J., Radovits T., Seres L., et al. Poly(ADP-ribose) polymerase inhibition reverses vascular dysfunction after gamma irradiation. Int J Radiat Oncol Biol Phys 65 (2006) 1528-1535
27. Jagtap P., and Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov 4 (2005) 421-440
28. Sharp C., Warren A., Oshima T., et al. PolyADP ribose-polymerase inhibitors prevent the upregulation of ICAM-1 and E-selectin in response to Th1 cytokine stimulation. Inflammation 25 (2001) 157-163
29. Martin M., Lefaix J.L., and Delanien S. TGF-β1 and radiation fibrosis: A master switch and a specific therapeutic target?. Int J Radiat Oncol Biol Phys 47 (2000) 277-290
30. Sporn M.B. The importance of context in cytokine action. Kidney Int 51 (1997) 1352-1354
31. Barcellos-Hoff M.H. How do tissues respond to damage at the cellular level?. The role of cytokines in irradiated tissues. Radiat Res 150 (1998) S109-S120